hi all

i have taken the liberty of attaching
hyper-linked PubMed identification numbers to joe's CSR list
which means you *should* be able to double click on the PubMed URL web address
to be whisked there automatically [depending on your e-mail software program]

janet

----------------------------------------------------
From: J. R. Bruman <[log in to unmask]>
Subj: CSR FEB 00
To:   [log in to unmask]
Date: Sun, 30 Jan 2000 21:57:41 -0500
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CURRENT SCIENCE REVIEWS  By Joe Bruman   February 00

Hallett M et al; Neur 1999;53:1910-1921:
Tutorial and historical review of various surgical techniques
for use in treatment of PD:
PMID: 10599758
<A HREF="http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?form=4&db=m&term=10599758&dispmax=10&relentrezdate=No+Limit"> http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?form=4&db=m&term=10599758&dispmax=10&relentrezdate=No+Limit </A>

Samii A et al; Neur 1999;53:2097-2102:
Positron-emission tomography (PET) studies of parkinsonism
associated with mutation in the a-synuclein gene show a pattern
indistinguishable from idiopathic PD:
PMID: 10599788
<A HREF="http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?form=4&db=m&term=10599788&dispmax=10&relentrezdate=No+Limit"> http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?form=4&db=m&term=10599788&dispmax=10&relentrezdate=No+Limit </A>

Pal P et al; Neur 2000;54:244-247:
Three-fourths of PD patients drool saliva, not from excess
secretion but from failure to swallow. Authors reduced
salivation by intraparotid injections of botulism toxin A:
PMID: 10636161
<A HREF="http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?form=4&db=m&term=10636161&dispmax=10&relentrezdate=No+Limit"> http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?form=4&db=m&term=10636161&dispmax=10&relentrezdate=No+Limit </A>

Nutt J, Carter J; Neur 2000;54:247-250:
L-dopa has two therapeutic effects with different time
courses. The short-duration response (SDR) follows plasma
concentration within hours, while long-duration response
(LDR) requires several days for changes to appear. In 7
subjects who quit L-dopa for 3 days, apomorphine infusion
kept the subjects "on", suggesting that LDR doesn't depend
on dopamine storage.
PMID: 10636162
<A HREF="http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?form=4&db=m&term=10636162&dispmax=10&relentrezdate=No+Limit"> http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?form=4&db=m&term=10636162&dispmax=10&relentrezdate=No+Limit </A>

Olanow C et al; Neur 2000;54:274-277:
The report of "sleep attacks" that led to driving accidents
(CSR JUL 99) prompted a batch of critics, most of whom seem
reluctant to accept that the sudden blackouts differ from
the familiar drowsiness caused by many PD drugs. Letters are
5 con, 1 pro, and 1 neutral (suggests similar blackout from
Permax).
PMID: 10636179
<A HREF="http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?form=4&db=m&term=10636179&dispmax=10&relentrezdate=No+Limit"> http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?form=4&db=m&term=10636179&dispmax=10&relentrezdate=No+Limit </A>

Obeso J et al; J Neur N'surg Psych 2000;68:122-123:
Exchange over recent paper (CSR MAY 99) about deep-brain
stimulation of the subthalamic nucleus for levodopa-induced
dyskinesia.

J Neur N'surg Psych 2000;68 (full-page ad for UK):
The long-lasting dopamine agonist cabergoline (Cabaser) taken only
once a day can relieve fluctuating symptoms of PD. It is sold in the
U.S. as Dostinex, but only for treatment of hyperprolactinemia, a
disorder of the pituitary gland.

York M et al; Brain 1999;122:2209-2220:
They reviewed 10 different studies of neuropsychological outcome
following unilateral pallidotomy, finding general areement that the
procedure is safe and effective, with relatively few cognitive
changes, but complain about quality of the studies.
PMID: 10581217
<A HREF="http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?form=4&db=m&term=10581217&dispmax=10&relentrezdate=No+Limit"> http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?form=4&db=m&term=10581217&dispmax=10&relentrezdate=No+Limit </A>

Kompoliti K; Clin Neuropharm 1999;22:318-326:
Reviews effects of estrogen on dopaminergic movement control,
but with no specific conclusions.
PMID: 10626091
<A HREF="http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?form=4&db=m&term=10626091&dispmax=10&relentrezdate=No+Limit"> http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?form=4&db=m&term=10626091&dispmax=10&relentrezdate=No+Limit </A>

Narabayashi H et al; Clin Neuropharm 1999;22:340-346:
Double-blind controlled safety study on 50 PD patients of the new
MAO-B inhibitor lazabemide (Ro19-6327) showed no significant effect
on heart rhythm, possible minor orthostatic hypotension.
PMID: 10626094
<A HREF="http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?form=4&db=m&term=10626094&dispmax=10&relentrezdate=No+Limit"> http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?form=4&db=m&term=10626094&dispmax=10&relentrezdate=No+Limit </A>

Contin M et al; Clin Neuropharm 1999;22:356-358:
In 8 patients with fluctuating-stage PD, they compared a new dispersible
formulation of levodopa/benserazide (Madopar) with the standard tablets,
but found no important differences.
PMID: 10626097
<A HREF="http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?form=4&db=m&term=10626097&dispmax=10&relentrezdate=No+Limit"> http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?form=4&db=m&term=10626097&dispmax=10&relentrezdate=No+Limit </A>

Latchman D, Coffin S; Mov Disord 2000;15:9-17:
They discuss the use and choice of different viral vectors for delivery
of modified genes in treatment of PD.
PMID: 10634236
<A HREF="http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?form=4&db=m&term=10634236&dispmax=10&relentrezdate=No+Limit"> http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?form=4&db=m&term=10634236&dispmax=10&relentrezdate=No+Limit </A>

Chaudhuri K et al; Mov Disord 2000;15:18-23:
Ongoing study since 1995 shows, even after excluding multiple system
atrophy (MSA) and progressive supranuclear palsy (PSP), that prevalence
of atypical, sporadic, L-dopa-resistant PD is 3- to 4-fold greater
among Afro-Caribbean or Indian immigrants to the UK than among the
remainder population.
PMID: 10634237
<A HREF="http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?form=4&db=m&term=10634237&dispmax=10&relentrezdate=No+Limit"> http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?form=4&db=m&term=10634237&dispmax=10&relentrezdate=No+Limit </A>

Bandmann O et al; Mov Disord 2000;15:30-35:
They refine and confirm their earlier report of association between
familial PD and a certain mutant of the gene for N-acetyl- transferase 2 (NAT2).
PMID: 10634239
<A HREF="http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?form=4&db=m&term=10634239&dispmax=10&relentrezdate=No+Limit"> http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?form=4&db=m&term=10634239&dispmax=10&relentrezdate=No+Limit10634239 </A>

Fung V et al; Mov Disord 2000;15:48-55:
Detailed study in 20 patients of PD-related rigidity suggests that
clinical rating scales should include separate scores for resting
and activated rigidity.
PMID: 10634241
<A HREF="http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?form=4&db=m&term=10634241&dispmax=10&relentrezdate=No+Limit"> http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?form=4&db=m&term=10634241&dispmax=10&relentrezdate=No+Limit </A>

Martinez-Martin P et al; Mov Disord 2000;15:65-70:
Applying several standard rating scales in 4-month followup of 11
advanced-PD pallidotomy recipients, they find significantly improved
quality of life.
PMID: 10634243
<A HREF="http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?form=4&db=m&term=10634243&dispmax=10&relentrezdate=No+Limit"> http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?form=4&db=m&term=10634243&dispmax=10&relentrezdate=No+Limit </A>

Stocchi F et al; Mov Disord 2000;15:71-76:
An instrumented study of anorectal function in 17 PD patients and
16 with multiple system atrophy (MSA) showed similar abnormality in
straining pattern and anal tone.
PMID: 10634244<A HREF="http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?form=4&db=m&term=10634244&dispmax=10&relentrezdate=No+Limit"> http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?form=4&db=m&term=10634244&dispmax=10&relentrezdate=No+Limit </A>

Raethjen J et al; Mov Disord 2000;15:84-94:
Against the conventional belief that tremor in PD or ET is governed
by a single oscillating circuit, an instrumented study of 22 PD and
28 ET patients shows that there are multiple oscillators.
PMID: 10634246
<A HREF="http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?form=4&db=m&term=10634246&dispmax=10&relentrezdate=No+Limit"> http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?form=4&db=m&term=10634246&dispmax=10&relentrezdate=No+Limit </A>

Oliveri R et al; Mov Disord 2000;15:127-131:
They checked 135 PD patients and 202 normal controls for four
different polymorphisms (mutations) of the dopamine D2 receptor
(DRD2) gene and found that two of them are associated with PD.
PMID: 10634251
<A HREF="http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?form=4&db=m&term=10634251&dispmax=10&relentrezdate=No+Limit"> http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?form=4&db=m&term=10634251&dispmax=10&relentrezdate=No+Limit </A>

Shulman L et al; Mov Disord 2000;15:132-135:
Motor symptoms of a PD patient significantly worsened during her
pregnancy, and 15 months after a normal full-term delivery had not
returned to former baseline scores.
PMID: 10634252
<A HREF="http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?form=4&db=m&term=10634252&dispmax=10&relentrezdate=No+Limit"> http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?form=4&db=m&term=10634252&dispmax=10&relentrezdate=No+Limit </A>

Hariz M et al; Mov Disord 2000;15:136-139:
Bilateral deep-brain stimulation of the subthalamic nucleus in a
PD patient with cognitive impairment improved motor symptoms, but
cognition, speech, and drooling, even with stimulation off, got worse.
PMID: 10634253
<A HREF="http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?form=4&db=m&term=10634253&dispmax=10&relentrezdate=No+Limit"> http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?form=4&db=m&term=10634253&dispmax=10&relentrezdate=No+Limit </A>

Di Rocco A, Werner P; Ann Neur 2000;47:136:
Questions earlier report (CSR AUG 99) about effect of long-term
levodopa use upon dopamine receptor distribution.
PMID: 10632116
<A HREF="http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?form=4&db=m&term=10632116&dispmax=10&relentrezdate=No+Limit"> http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?form=4&db=m&term=10632116&dispmax=10&relentrezdate=No+Limit </A>

--
J. R. Bruman   (818) 789-3694
3527 Cody Road
Sherman Oaks, CA 91403-5013

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janet paterson
52 now / 41 dx / 37 onset
a new voice: http://www.geocities.com/janet313/
613 256 8340 PO Box 171 Almonte Ontario Canada K0A 1A0