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PARKINSN  September 2000, Week 4

PARKINSN September 2000, Week 4

Subject:

PMID: 10918346: The HAMD-17 and MADRS scales for screening depression in PD

From:

janet paterson <[log in to unmask]>

Reply-To:

Parkinson's Information Exchange Network <[log in to unmask]>

Date:

Sat, 23 Sep 2000 06:21:46 -0700

Content-Type:

text/plain

Parts/Attachments:

Parts/Attachments

text/plain (66 lines)

The validity of the Hamilton and Montgomery-Asberg depression rating
scales as screening and diagnostic tools for depression in
Parkinson's
disease.

The concurrent validity of the Hamilton Rating Scale for Depression
(HAMD-17) and the Montgomery-Asberg Depression Rating Scale (MADRS)
against the DSM-IV diagnosis 'depressive disorder' was assessed in
patients with Parkinson's disease (PD).

63 non-demented Parkinson's Disease (PD) patients who attended the
outpatient department of an academic hospital were diagnosed
according to a standardised research protocol.

This protocol consisted of the Schedules for Clinical Assessment in
Neuropsychiatry (SCAN) to establish the presence or absence of
'depressive disorder' according to the DSM-IV criteria, as well as
the HAMD-17 and the MADRS.

Receiver Operating Characteristics curves (ROC curves) were obtained
and the positive and negative predictive values (PPV, NPV) were
calculated for different cut-off scores.

Maximum discrimination between depressed and non-depressed patients
was reached at a cut-off score of 13/14 for the HAMD-17, and at 14/15
for the MADRS. At lower cut-offs, like 11/12 for the HAMD-17 and
14/15 for the MADRS, the high sensitivity and NPV make these scales
good screening instruments.

At higher cut-offs, such as 16/17 for the HAMD-17 and 17/18 for the
MADRS, the high specificity and PPV make these instruments good
diagnostic instruments.

The diagnostics performance of the HAMD-17 is slightly better than
that of the MADRS.

This study shows that it is justified to use the HAMD-17 and the
MADRS
to measure depressive symptoms in both non-depressed and depressed PD

patients, to diagnose depressive disorder in PD, and to dichotomize
patient samples into depressed and non-depressed groups.

Copyright 2000 John Wiley & Sons, Ltd.

Int J Geriatr Psychiatry 2000 Jul;15(7):644-9
Leentjens AF, Verhey FR, Lousberg R, Spitsbergen H, Wilmink FW
Department of Psychiatry, Maastricht University Hospital, The
Netherlands.
[log in to unmask]
PMID: 10918346, UI: 20379274

http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10918346&dopt=Abstract




=====
janet paterson
EMAIL: [log in to unmask]
WEB-SITE: a new voice: http://www.geocities.com/janet313/

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December 1999, Week 5
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December 1997, Week 5
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December 1995, Week 5
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