Hello again

There may be some misunderstandings here in regard
to
the Low Protrein Diet thread. I've been doing some
resesarch
in the PARKINSN list archives according to Janet
Paterson's
wonderful instructions on her website
(www.geocities.com/janet313/)
and came up with some excellent prior postings in
regard to
the so-called 'cheese effect'.

Anyone can "mine for gold" in the PARKINSN LIST
ARCHIVES;
you do not have to be a listmemeber. And it is
relatively
easy. This is what I found:


=========================================================
>
> > search 'cheese effect' in parkinsn
> -> 16 matches.
>
> Item #   Date   Time  Recs   Subject
> ------   ----   ----  ----   -------
> 000466 94/04/25 14:02   49   Fava beans & eldepryl,
> Part II
> 000944 94/09/26 11:09  243   Deprenyl - A
> Parkinson's Drug - 1994 Update
> 001925 95/02/21 10:27   62   Eldepryl
> 002290 95/03/20 09:06  201
> 005523 95/09/20 13:02   67   MAO Type A & B
> 020810 97/02/26 04:36   77   Re: Eldepryl FAQ
> 021140 97/03/05 14:18   13   "The cheese effect"
> 021150 97/03/05 19:51   32   Re: "The cheese effect"
> 021159 97/03/05 23:34   32   Re: "The cheese effect"
> 021161 97/03/06 00:10   34   Re: "The cheese effect"
> 021163 97/03/06 00:38   29   Re: "The cheese effect"
> 021194 97/03/07 00:34   14   Cheese effect
> 028171 97/07/22 14:50   39   Eldepryl -Reply
> 034368 97/12/05 07:56   85   Re: Over-the-Counter
> drugs
> 038389 98/03/02 05:37   41   the facts about mao
> inhibitors and selegiline
> 051732 98/11/16 07:55   27   Re: Tasmar/ 4 QUESTIONS
> /Eldepryl unnecessary?
>
> To order a copy of these postings, send the
> following command:
>
> // GETPOST PARKINSN 466 944 1925 2290 5523 20810
> 21140 ,
> 21150 21159 21161 21163 21194 28171 34368 38389
> 51732
>
> >>> Item #466 (25 Apr 1994 14:02) - Fava beans &
> eldepryl, Part II
> hydrochloride) for the first time, specifically gave
> out a diet warning
> against the so called "cheese effect".
>                        ^^^^^^^^^^^^^
> He would be very correct IF eldepryl was a monoamine
> oxidase inhibitor, type
> A.   It is not.  Eldepryl IS a monoamine oxidase
> inhibitor, type B, and does
> not have the "cheese effect".  The chemical name for
> what we know as
>               ^^^^^^^^^^^^^
> "eldepryl" is:
> (R)-(-)-N,2-dimethly-N-2-propynylphenethylamine.  It
> was first
> ***************
> cruise ship as "a medical emergency" with extremely
> high blood pressure.
> Later, after test, it was determined that the
> "cheese effect diet" was
>
> ^^^^^^^^^^^^^
> reactive with MAOs (before the type-A, and type-B
> was fully recognized).
> Some, who refuse to see that there are "modifiers"
> in the course of history
> stll say if it is an MAO it has the cheese effect,
> when in fact the MAO-B
>                                     ^^^^^^^^^^^^^
> does not have the cheese effect at all unless an
> unusually (very) high dosage
>                   ^^^^^^^^^^^^^
> is taken  ...not likely where the standard dose is 2
> tabs a day.
>
> >>> Item #944 (26 Sep 1994 11:09) - Deprenyl - A
> Parkinson's Drug - 1994
> Update
> important advantage of selegiline compared with
> other MAO
> inhibitors was its lack of the "cheese effect". This
> effect is caused
>                                 ^^^^^^^^^^^^^
> by the uptake of a food constituent, tyramine, which
> is present
>
> >>> Item #1925 (21 Feb 1995 10:27) - Eldepryl
> Once again, the pharmacy is WRONG. You would be
> doing a lot of folks a big
> service by telling them this. The "cheese effect" is
> a warning applied to MAO
>                                    ^^^^^^^^^^^^^
> type A inhibitors. Eldepryl is a Type B. Totally
> different. There is NO
>
> >>> Item #2290 (20 Mar 1995 09:06)
> disease (PD). An important advantage of selegiline
> compared with other MAO
> inhibitors was its lack of the "cheese effect". This
> effect is caused by
>                                 ^^^^^^^^^^^^^
> the uptake of a food constituent, tyramine, which is
> present in high
>
> >>> Item #5523 (20 Sep 1995 13:02) - MAO Type A & B
> inhibitor compound, known as selegiline
> hydrochloride.  This drug inhibited
> tyramine and did not create the "cheese effect" of
> the Type A MAO
>                                  ^^^^^^^^^^^^^
>  inhibitors.  Dr. Knoll's compound, selegiline, is
> also known as Compound
>
> >>> Item #20810 (26 Feb 1997 04:36) - Re: Eldepryl
> FAQ
> CONSIDERED TO BE NO DANGER WITH THE FOODS LISTED
> ABOVE (THIS IS KNOWN AS
> THE "CHEESE EFFECT".)
>      ^^^^^^^^^^^^^
>
> >>> Item #21140 (5 Mar 1997 14:18) - "The cheese
> effect"
> From:         "Rosalyn R. Boyle" <[log in to unmask]>
> Subject:      "The cheese effect"
>                    ^^^^^^^^^^^^^
>
>      Please explain what is meant by "The cheese
> effect" as that phrase/term
>
> ^^^^^^^^^^^^^
> has been used to apply to PD.
>
> >>> Item #21150 (5 Mar 1997 19:51) - Re: "The cheese
> effect"
> From:         "Bernard Barber, Ph.D."
> <[log in to unmask]>
> Subject:      Re: "The cheese effect"
>                        ^^^^^^^^^^^^^
>
> At 02:18 PM 3/5/97 -0500, you wrote:
> >     Please explain what is meant by "The cheese
> effect" as that phrase/term
>
> ^^^^^^^^^^^^^
> >has been used to apply to PD.
> ***************
> remiss, and certainly would be accused of all sorts
> of things, if I did not
> mention the other meaning to " The Cheese Effect "
> This phenomenon occurred
>                                    ^^^^^^^^^^^^^
> after the football team from Green Bay Wisconsin won
> the Super Bowl. All
> ***************
> many are still dancing in the streets.
> All of this has been termed "The Cheese Effect" ( I
> know of one PWP who is
>                                  ^^^^^^^^^^^^^
> still dancing, yeah he lives in Wisconsin.)
>
> >>> Item #21159 (5 Mar 1997 23:34) - Re: "The cheese
> effect"
> From:         "Charles T. Meyer"
> <[log in to unmask]>
> Subject:      Re: "The cheese effect"
>                        ^^^^^^^^^^^^^
>
> ***************
>
>  But on a more serious note Rose- the cheese effect
> I think that you are
>                                       ^^^^^^^^^^^^^
>  referring to is the effect when one takes a certain
> type of
> ***************
>  pressure.  How this relates to PD is that Eldepryl
> is in that group
>  although in the doses we take it the cheese effect
> is usually not a
>                                       ^^^^^^^^^^^^^
> problem.  It usually takes about 30 mg / day of
> Eldepryl to trigger the
> "cheese effect".  The usual dose for PD is 5-10
> mg/day.
>  ^^^^^^^^^^^^^
>
> >>> Item #21161 (6 Mar 1997 10:47) - Re: "The cheese
> effect"
> From:         will johnston
> <[log in to unmask]>
> Subject:      Re: "The cheese effect"
>                        ^^^^^^^^^^^^^
>
> At 02:18 PM 3/5/97 -0500, you wrote:
> >     Please explain what is meant by "The cheese
> effect" as that phrase/term
>
> ^^^^^^^^^^^^^
> >has been used to apply to PD.
> ***************
>
>         The cheese effect is  generally a racing
> heartbeat, skyrocketing
>             ^^^^^^^^^^^^^
> blood pressure brought on by eating foods high in
> tyrosines. These foods are
>
> >>> Item #21163 (6 Mar 1997 00:00) - Re: "The cheese
> effect"
> Organization: Five Star Living,Inc. 604 East
> Pitkin,Fort Collins,CO 80524
> Subject:      Re: "The cheese effect"
>                        ^^^^^^^^^^^^^
>
> ***************
> >
> >      Please explain what is meant by "The cheese
> effect" as that phrase/term
>
> ^^^^^^^^^^^^^
> > has been used to apply to PD.
>
> >>> Item #21194 (7 Mar 1997 00:00) - Cheese effect
> Organization: unorganized
> Subject:      Cheese effect
>               ^^^^^^^^^^^^^
>
> To clarify the hypothetical "cheese effect," --
> There are two MAO
>                              ^^^^^^^^^^^^^
> inhibitors. The one which has the cheese effect is a
> type "A". Elderpryl
>                                   ^^^^^^^^^^^^^
> is a type "B". Thus NO cheese effect. Two totally
> different things.
>                        ^^^^^^^^^^^^^
> --
>
> >>> Item #28171 (22 Jul 1997 14:50) - Eldepryl
> -Reply
> probably because it was shown that too much MAO
> inhibitor
> [over 10 mg] caused the "cheese effect" i.e.,  in
> combination
>                          ^^^^^^^^^^^^^
> with other medications and foods (dairy) produces
> sudden
>
> >>> Item #34368 (5 Dec 1997 07:56) - Re:
> Over-the-Counter drugs
> highly selective inhibitor of the Type B form of MAO
> and rarely
> has been associated the "cheese effect common to the
> non-
>                          ^^^^^^^^^^^^^
> selective MAO inhibitors."
>
> >>> Item #38389 (2 Mar 1998 05:37) - the facts about
> mao inhibitors and
> selegiline
>
> the subject of mao inhibitors and the so-called
> 'cheese effect'
>
> ^^^^^^^^^^^^^
> seems to pop up every few months
> ***************
>      and then enter the following terms in the
> search query window:
>      mao inhibitor AND cheese effect
>                        ^^^^^^^^^^^^^
>
> >>> Item #51732 (16 Nov 1998 07:55) - Re: Tasmar/ 4
> QUESTIONS /Eldepryl
> unnecessary?
> Deprenyl acts solely on the type MAO found in the
> brain, thereby (at
> recommended doses) obviating a problem with the so
> called "cheese effect"-(a
>
>       ^^^^^^^^^^^^^
> whole other story--it leads to hypertensive crises)
> found in the use of
>
>
=========================================================

Happy New Year!

Jim T.


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