Has anyone had success with amantadine helping to control dyskinesias?
We've found it mostly useful for stiffness.

T. and C. Menser

----- Original Message -----
From: Donald Diswinka <[log in to unmask]>
To: <[log in to unmask]>
Sent: Friday, November 29, 2002 12:33 PM
Subject: Re: Entacapone


> Nigel
>
> I am not a doctor but ??Dyskinesias is usually from drug overdosing and
> are seperate from tremors. Amantadine is what is used to control
> dyskinesias--I have used Entacapone(Comtan) here for over a year now.
> Entacapone  has Extended Sinemet  without increasing it's dosage on
> times for me an extra 45-90 minutes depending mostly on stress
> encountered during that time.  My Sinemet 50/200 was wearing off in 3
> hrs 20 minutes average time. Now that same dose with Entacapone lasts 4
> hrs +.  I am not sure from your description of meds that while it works
> in my case  and is an excellent compliment with Sinemet,  I have no
> experience using it with any of the drugs you listed, therefore cannot
> say  if it will help your Madopar. No side effects encountered
> whatsoever from iEntacapone.
>
> Note: " Selegiline(eldepryl). Its main use is as an addition to
> treatment with levodopa, particularly for people who experience
> fluctuations in their mobility through the day. However over the past
> few years Selegiline, has shown that it may have a detrimental effect
> on the action of the heart." A study is being done to review its
> affects. Eldepryl belongs to a class of drugs known as MAO inhibitors.
> Amitriptyline- is contraindicated with any MAO inhibiters. " It should
> not be given concomitantly with a MAO inhibiting compound."
>
> Your Cabaser--A dopamine agonist is what is supposed to help Madopar be
> smooth throughout its cycle. I am wondering if the neuro gives you
> Entacapone  what will he do with Cabaser and or Selegiline which are
> all designed to do the same " smooth out"  but with a different method?
>
> Don
> 54/5
>
>
> On Friday, November 29, 2002, at 02:18 AM, nigel harland wrote:
>
> > Hello all,
> >             After several years of a reasonably managed medication
> > regime, the dreaded dyskenesia is making a slow but definite comeback.
> > I mentioned this to my Neuro this week, and he recommended that I
> > include Entacapone into my regime.  Has anyone any experience of
> > Entacapone, good or bad, which they could share with me??
> > My present meds are Madopar dispersible (187.5mg) 4 times a day,
> > Cabaser 4mg once a day, Amantadine 200mg once a day, Eldepryl 10mg
> > once a day, and finally Amitriptyline 50mg once a day.
> >
> > Thanks,
> > Nigel age 48, dx aged 35
>
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