I get dyskinesia at end of day when I take Comtan. You may need to space out
the Sinemet or take a 1/2 comtan
----- Original Message -----
From: "Chris Lui" <[log in to unmask]>
To: <[log in to unmask]>
Sent: Thursday, September 18, 2003 10:21 PM
Subject: Re: COMTAN


> I have taken COMTAN for only two days, and already felt that I enjoyed
more
> ON time and less OFF time at the end of dose.  I think it is a good drug
for
> me.  However, sometimes I felt a bit too tense and jerky with the
> medication.  Does it mean that I am on the verge of having dyskynesia (I
> used to not having dyskynesia) and should reduce Sinemet?  Could anyone
> advice me with similar experiences?
>
> Chris Lui
>
> ----- Original Message -----
> From: "David Moreland" <[log in to unmask]>
> To: <[log in to unmask]>
> Sent: Thursday, September 18, 2003 1:25 PM
> Subject: Re: COMTAN
>
>
> > the pallidotomy marginally helped a lot of things. It
> > not only got rid of the hellish dyskinesia.  Since my
> >                      PVP I dfont have Migrains any
> > more I bagan sleeping all night,  I was able to drive
> > again,my PD medications started to work again they
> > hadn't been working
> >
> > David Moreland
> >
> >
> >
> > --- "Nancy S. deGrazia" <[log in to unmask]>
> > wrote:
> > > David - that's good to hear.  Were your PD symptoms
> > > across the board
> > > (tremor, gait problems,  freezing, etc)? And which
> > > ones did the
> > > pallidotomy help?
> > >
> > > Nancy deG
> > >
> > > David Moreland wrote:
> > >
> > > >--- "Nancy S. deGrazia" <[log in to unmask]>
> > > >wrote:
> > > >
> > > >
> > > >>Thank you, Chris :
> > > >>No. my "end of dose " phenomenom is the onset of
> > > >>dyskinesia. I seem to
> > > >>have both "peak dose" and "end of dose"
> > > dyskinesia.
> > > >>I have been taking
> > > >>sinemet for almost 10 years and over that period
> > > >>have added eldepryl,
> > > >>permax, mirapex and amantadine. I guess the reason
> > > I
> > > >>am taking so many
> > > >>different things is that I am hypersensitive to
> > > >>levadopa. I take 1/4 of
> > > >>a 25/100 every 90 minutes and if I take more the
> > > >>dyskinesia is just awful..
> > > >>
> > > >>Anyone else with this kind of problem?
> > > >>I used to have diskinesias  that on a 1  to  10
> > > >>
> > > >>
> > > >scale mine were up to 13 or 14 . Then i had a
> > > >pallidototomy.   For the most part I have been free
> > > of
> > > >dyskinesia  since then (1995}
> > > >David Moreland
> > > >
> > > >
> > > >>Nancy deG
> > > >>
> > > >>Chris Lui wrote:
> > > >>
> > > >>
> > > >>
> > > >>>Hi Nancy:
> > > >>>
> > > >>>My end of dose phenomenon refers to premature
> > > >>>
> > > >>>
> > > >>ending of the effectiveness of
> > > >>
> > > >>
> > > >>>the medicine, a shortened drug effect experienced
> > > >>>
> > > >>>
> > > >>after 3 years of
> > > >>
> > > >>
> > > >>>medication.  Have you got the similar problem?
> > > >>>
> > > >>>Chris Lui
> > > >>>
> > > >>>----- Original Message -----
> > > >>>From: "Nancy S. deGrazia"
> > > <[log in to unmask]>
> > > >>>To: <[log in to unmask]>
> > > >>>Sent: Tuesday, September 16, 2003 6:57 PM
> > > >>>Subject: Re: COMTAN
> > > >>>
> > > >>>
> > > >>>
> > > >>>
> > > >>>
> > > >>>
> > > >>>>Chris Lui:- iis the "end of dose" phenomenon you
> > > >>>>
> > > >>>>
> > > >>referred to (A) a
> > > >>
> > > >>
> > > >>>>premature ending of the effectiveness of the
> > > >>>>
> > > >>>>
> > > >>medecine or (b) dyskinesia
> > > >>
> > > >>
> > > >>>>which manifests itself at the end of a dose?
> > > >>>>
> > > >>>>Your response will clarify my situation for
> > > which
> > > >>>>
> > > >>>>
> > > >>I would be very
> > > >>
> > > >>
> > > >>>>
> > > >>>>
> > > >>>grateful.
> > > >>>
> > > >>>
> > > >>>
> > > >>>
> > > >>>>Nancy S deGrazia
> > > >>>>
> > > >>>>
> > > >>>>
> > > >>>>Chris Lui wrote:
> > > >>>>
> > > >>>>
> > > >>>>
> > > >>>>
> > > >>>>
> > > >>>>>Hi ALL,
> > > >>>>>
> > > >>>>>Today my neuro starts putting me on COMTAN to
> > > >>>>>
> > > >>>>>
> > > >>addrerss the end of dose
> > > >>
> > > >>
> > > >>>>>
> > > >>>>>
> > > >>>phenomenon.  Any one has got any advice or
> > > comment
> > > >>>
> > > >>>
> > > >>about the use of this
> > > >>
> > > >>
> > > >>>drug?  Be it favourable or adverse,  your
> > > >>>
> > > >>>
> > > >>experience would certainly help!
> > > >>
> > > >>
> > > >>>Thanks!
> > > >>>
> > > >>>
> > > >>>
> > > >>>
> > > >>>>>Chris Lui
> > > >>>>>
> > > >>>>>
> > > >>>>>
> > >
> >
>>>>----------------------------------------------------------------------
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> > > >>>>>In the body of the message put: signoff
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