Hi Shirley:
    We are just comparing notes. If there is a higher percentageof people
first diagnozed with hyothyroidism (or hyperthyroidism), this may indicate
that malfunction of thyroid and the accompanying chronic fatigueness could
be taken as a warning as to what might follow. So also is the chronic pain
phenomenon.  So far nobody attributes these as probable early symptoms of
the oncoming manifestation of PD.
    At least in my case, I am fairly confident that this is so.
    I am just stating my personal expereince and am trying to rationalize
what might be going on in my body. For example, as soon as I take celebrex,
not only my pain disappears, so do all the other symptoms of PD including
tremer, bradykinesia, and even postural instability.
      Celebrex is an antiinflammatory agent, and is a COX-2 (Cyclo-oxigenase
2) inhibitor.  It can pass through the blood brain barrier. For the
progression of PD, COX2 function is required. If you can inhibit it, could
we slow the progression of PD?
    I personally think, we can.  Celebrex is relatively safer than other
non-steroidal antiinflamation drugs (NSAIDs)  to consume.  I have started
taking it whenever I have pain, because I do not have time to wait for the
results of a doubleblind study, which nobody has even undertaken yet. For me
it is important to save my neurons from dying right now and I shall do
anything to stop them from doing so.  Because, once we lose them, it is very
difficult to make fresh ones (More on this later).
    I am just sharing my experience.  I am not giving any advise nor I am
qualified to give one. When you see your doctor next time, you can ask
her/him about this, if you like.
    Raj
**********
----- Original Message -----
From: "Shirley Lund" <[log in to unmask]>
To: <[log in to unmask]>
Sent: Thursday, February 26, 2004 2:50 PM
Subject: Re: Focus Needed... Pain & PD


> i just read several entries that folks were diagnosed with hypothyroidism
> around the time they were diagnosed with pd.  so was i...this must be
> common?  shirley
> ----- Original Message -----
> From: "Brightline" <[log in to unmask]>
> To: <[log in to unmask]>
> Sent: Wednesday, February 25, 2004 9:42 AM
> Subject: Focus Needed... Pain & PD
>
>
> > David:
> >     Thanks for sharing your experience.
> >     If we share our experiences like this, we probably should be able to
> get
> > a better handle on the various symptoms that might forewarn what is
coming
> > next to haunt us like PD or anything for that matter.
> >     PD as far as I know  is still diagnozed by the common symptoms such
as
> > tremor, micrographia (?) or small handwriting,
> >    dystonia, bradykinesia, postural instability etc.  These are probably
> the
> > symptoms that were used to recognize this disease originally by Dr.
> > Parkinson himself.
> >     Unfortunately, by the time one begins to show the physical symptoms,
> we
> > have lost about 70-80% of the dopaminergic neurons!  Once this has
> happenned
> > it is very difficult and time consuming to regain the dead neurons by
the
> > neuroregeneratve process that is constanly going on in our body.  As the
> PD
> > progresses more and more neurons are dying not only because of PD but
also
> > because of aging. This makes it tough on our body to regain the lost
> > neurons.  Therefore I think it is very important that we should be able
to
> > recognize the disease early and help regeneration of the endogenous
> neuronal
> > stem cells, which will help retardthe progression of the disease.
> >     More on this later.
> >     Raj
> > ************
> > ----- Original Message -----
> > From: "DAVID LEWIN" <[log in to unmask]>
> > To: <[log in to unmask]>
> > Sent: Tuesday, February 24, 2004 8:24 AM
> > Subject: Re: Focus Needed... Pain & PD
> >
> >
> > > To add to the list, I too was first diagnosed with hypothyroidism.
The
> > > synthyroid greatly reduced my fatigue for a while.  But then I was
> > diagnosed
> > > with PD, and that shifted my focus.   We need to know more obviously
> about
> > > the autoimmune response.  David
> > >
> > >
> > > >From: Brightline <[log in to unmask]>
> > > >Reply-To: Parkinson's Information Exchange Network
> > > ><[log in to unmask]>
> > > >To: [log in to unmask]
> > > >Subject: Re: Focus Needed... Pain & PD
> > > >Date: Thu, 19 Feb 2004 11:34:28 -0400
> > > >
> > > >My experience was slightly different.
> > > >I was diagnozed with hypothyroidism and started taking synthroid.
This
> > > >eliminated my fatigue for a while.  But, my pain took over my
> attention.
> > > >After a few years I was diagnozed with PD. As a hindsight, I now
> strongly
> > > >believe that if I had controlled my pain early enough, I would have
> > slowed
> > > >the prgression of PD.
> > > >Raj
> > > >*********
> > > >----- Original Message -----
> > > >From: "Wendy Siegel" <[log in to unmask]>
> > > >To: <[log in to unmask]>
> > > >Sent: Wednesday, February 18, 2004 2:19 PM
> > > >Subject: Re: Focus Needed... Pain & PD
> > > >
> > > >
> > > > > I see some commonalities between your wife's experience and my
> > > > > husband's, things that may or may not be coincidence.
> > > > >
> > > > > You wrote:
> > > > >
> > > > > "Does anyone else have any information that draws any correlation
> > > > > between
> > > > > inflammation, autoimmune disorders and PD?  ...  The first is
> > > > > where the Thyroid is attacked by the autoimmune system eventually
> > > > > causing it
> > > > > to underperform."
> > > > >
> > > > > My husband has recently developed a goiter. That was what
eventually
> > led
> > > > > me to diagnose his PD. After researching it and other symptoms on
> the
> > > > > web, I got the diagnoses down to hyperthyroidism or PD. The
thyroid
> > > > > doctor said all was normal, that's when I knew it was PD. He said
> they
> > > > > don't know the cause of the goiter. Rich still has it, some days
it
> is
> > > > > larger than other days. So far, we can't determine what affects
it.
> > > > >
> > > > >
> > > > > You wrote:
> > > > > "A great side effect during the course of treatment was an almost
> > > > > total elimination of her asthma symptoms (reduction of
inflammation
> in
> > > > > lungs).  Since we have stopped the steroids it seems she is now
> > > > > experiencing
> > > > > more pain."
> > > > >
> > > > > Rich had asthma as a child, and has in the past used steroids. He
> > hasn't
> > > > > had problems with asthma in years though.
> > > > >
> > > > > Wendy
> > > > >
> > > >
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