Hi  Listers,\\



On a  video of a teaching  session By Dr Iacono (I don't know spelling for
his  name) ON the tape he said that hypothyroidism   was  usually a
precursor of PD  and this usually happens  because of a low level
of   saratonon   and   vitamin B-6.I would encourage  to   get  hold of
that tape. I think  he has a private practice in Loma linda California
you  could get a copy of the video from his office


>0





>Shirley:
>     We are just comparing notes. If there is a higher percentageof people
>first diagnozed with hyothyroidism (or hyperthyroidism), this may indicate
>that malfunction of thyroid and the accompanying chronic fatigueness could
>be taken as a warning as to what might follow. So also is the chronic pain
>phenomenon.  So far nobody attributes these as probable early symptoms of
>the oncoming manifestation of PD.
>     At least in my case, I am fairly confident that this is so.
>     I am just stating my personal expereince and am trying to rationalize
>what might be going on in my body. For example, as soon as I take celebrex,
>not only my pain disappears, so do all the other symptoms of PD including
>tremer, bradykinesia, and even postural instability.
>       Celebrex is an antiinflammatory agent, and is a COX-2 (Cyclo-oxigenase
>2) inhibitor.  It can pass through the blood brain barrier. For the
>progression of PD, COX2 function is required. If you can inhibit it, could
>we slow the progression of PD?
>     I personally think, we can.  Celebrex is relatively safer than other
>non-steroidal antiinflamation drugs (NSAIDs)  to consume.  I have started
>taking it whenever I have pain, because I do not have time to wait for the
>results of a doubleblind study, which nobody has even undertaken yet. For me
>it is important to save my neurons from dying right now and I shall do
>anything to stop them from doing so.  Because, once we lose them, it is very
>difficult to make fresh ones (More on this later).
>     I am just sharing my experience.  I am not giving any advise nor I am
>qualified to give one. When you see your doctor next time, you can ask
>her/him about this, if you like.
>     Raj
>**********
>----- Original Message -----
>From: "Shirley Lund" <[log in to unmask]>
>To: <[log in to unmask]>
>Sent: Thursday, February 26, 2004 2:50 PM
>Subject: Re: Focus Needed... Pain & PD
>
>
> > i just read several entries that folks were diagnosed with hypothyroidism
> > around the time they were diagnosed with pd.  so was i...this must be
> > common?  shirley
> > ----- Original Message -----
> > From: "Brightline" <[log in to unmask]>
> > To: <[log in to unmask]>
> > Sent: Wednesday, February 25, 2004 9:42 AM
> > Subject: Focus Needed... Pain & PD
> >
> >
> > > David:
> > >     Thanks for sharing your experience.
> > >     If we share our experiences like this, we probably should be able to
> > get
> > > a better handle on the various symptoms that might forewarn what is
>coming
> > > next to haunt us like PD or anything for that matter.
> > >     PD as far as I know  is still diagnozed by the common symptoms such
>as
> > > tremor, micrographia (?) or small handwriting,
> > >    dystonia, bradykinesia, postural instability etc.  These are probably
> > the
> > > symptoms that were used to recognize this disease originally by Dr.
> > > Parkinson himself.
> > >     Unfortunately, by the time one begins to show the physical symptoms,
> > we
> > > have lost about 70-80% of the dopaminergic neurons!  Once this has
> > happenned
> > > it is very difficult and time consuming to regain the dead neurons by
>the
> > > neuroregeneratve process that is constanly going on in our body.  As the
> > PD
> > > progresses more and more neurons are dying not only because of PD but
>also
> > > because of aging. This makes it tough on our body to regain the lost
> > > neurons.  Therefore I think it is very important that we should be able
>to
> > > recognize the disease early and help regeneration of the endogenous
> > neuronal
> > > stem cells, which will help retardthe progression of the disease.
> > >     More on this later.
> > >     Raj
> > > ************
> > > ----- Original Message -----
> > > From: "DAVID LEWIN" <[log in to unmask]>
> > > To: <[log in to unmask]>
> > > Sent: Tuesday, February 24, 2004 8:24 AM
> > > Subject: Re: Focus Needed... Pain & PD
> > >
> > >
> > > > To add to the list, I too was first diagnosed with hypothyroidism.
>The
> > > > synthyroid greatly reduced my fatigue for a while.  But then I was
> > > diagnosed
> > > > with PD, and that shifted my focus.   We need to know more obviously
> > about
> > > > the autoimmune response.  David
> > > >
> > > >
> > > > >From: Brightline <[log in to unmask]>
> > > > >Reply-To: Parkinson's Information Exchange Network
> > > > ><[log in to unmask]>
> > > > >To: [log in to unmask]
> > > > >Subject: Re: Focus Needed... Pain & PD
> > > > >Date: Thu, 19 Feb 2004 11:34:28 -0400
> > > > >
> > > > >My experience was slightly different.
> > > > >I was diagnozed with hypothyroidism and started taking synthroid.
>This
> > > > >eliminated my fatigue for a while.  But, my pain took over my
> > attention.
> > > > >After a few years I was diagnozed with PD. As a hindsight, I now
> > strongly
> > > > >believe that if I had controlled my pain early enough, I would have
> > > slowed
> > > > >the prgression of PD.
> > > > >Raj
> > > > >*********
> > > > >----- Original Message -----
> > > > >From: "Wendy Siegel" <[log in to unmask]>
> > > > >To: <[log in to unmask]>
> > > > >Sent: Wednesday, February 18, 2004 2:19 PM
> > > > >Subject: Re: Focus Needed... Pain & PD
> > > > >
> > > > >
> > > > > > I see some commonalities between your wife's experience and my
> > > > > > husband's, things that may or may not be coincidence.
> > > > > >
> > > > > > You wrote:
> > > > > >
> > > > > > "Does anyone else have any information that draws any correlation
> > > > > > between
> > > > > > inflammation, autoimmune disorders and PD?  ...  The first is
> > > > > > where the Thyroid is attacked by the autoimmune system eventually
> > > > > > causing it
> > > > > > to underperform."
> > > > > >
> > > > > > My husband has recently developed a goiter. That was what
>eventually
> > > led
> > > > > > me to diagnose his PD. After researching it and other symptoms on
> > the
> > > > > > web, I got the diagnoses down to hyperthyroidism or PD. The
>thyroid
> > > > > > doctor said all was normal, that's when I knew it was PD. He said
> > they
> > > > > > don't know the cause of the goiter. Rich still has it, some days
>it
> > is
> > > > > > larger than other days. So far, we can't determine what affects
>it.
> > > > > >
> > > > > >
> > > > > > You wrote:
> > > > > > "A great side effect during the course of treatment was an almost
> > > > > > total elimination of her asthma symptoms (reduction of
>inflammation
> > in
> > > > > > lungs).  Since we have stopped the steroids it seems she is now
> > > > > > experiencing
> > > > > > more pain."
> > > > > >
> > > > > > Rich had asthma as a child, and has in the past used steroids. He
> > > hasn't
> > > > > > had problems with asthma in years though.
> > > > > >
> > > > > > Wendy
> > > > > >
> > > > >
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