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PARKINSN  April 2004, Week 3

PARKINSN April 2004, Week 3

Subject:

Re: Depression, Wellbutrin, Parkinson's

From:

Greg Louis <[log in to unmask]>

Reply-To:

Parkinson's Information Exchange Network <[log in to unmask]>

Date:

Sun, 18 Apr 2004 07:09:46 -0400

Content-Type:

text/plain

Parts/Attachments:

Parts/Attachments

text/plain (39 lines)

On 20040417 (Sat) at 0941:27 -0500, Lynn Maruska wrote:
> Any experiences with taking Wellbutrin for depression and experiencing PD
> symptoms?  Doctors have discounted the connection because symptoms are
> unilateral but .....  I had noticed when I'd increase my dosage of
> Wellbutrin my PD symptoms increased.  Recently had to stay off Wellbutrin
> for a couple of days because of stomach flu.  All PD symptoms reduced and
> even seemed to be gone.  Dr. put me on lower dosage of Wellbutrin with
> extended release.  Within a day symptoms returned.  I also take low dosage
> of Effexor.  All symptoms on left side.  Had shingles a few years ago also
> on left side.  Perhaps Wellbutrin exasperates PD symptoms.

Sounds familiar, except in my case it's the right side and the symptoms
appeared for the first time when I tried Effexor last July.  They
seemed to get milder after I stopped taking Effexor, but unfortunately,
they didn't go away (and seem to be slowly worsening month by month
since then).  I don't think Effexor was a cause, but perhaps it acted
as a trigger.

Since the chemistry of both PD and most antidepressants is understood
only at a fairly superficial level, there could be some as yet unknown
relation.  Most doctors work empirically; they can hardly do otherwise,
since it would be more than a full-time job just staying current in all
the fields a GP needs to know about.  Even specialists tend to read
review literature rather than original science.  Having to make
life-and-death decisions on insufficient evidence (even when the
reading is done, science itself can be incomplete or plain wrong) tends
to make some physicians appear dogmatic; I think it's a kind of
psychological defense against fundamental insecurity.  I don't mean
that as a criticism, either: medicine is a hard job, and that's one of
the factors that make it so.

--
| G r e g  L o u i s         | gpg public key: 0x400B1AA86D9E3E64 |
|  http://www.bgl.nu/~glouis |   (on my website or any keyserver) |
|  http://wecanstopspam.org in signatures helps fight junk email. |

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December 1999, Week 5
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December 1998, Week 5
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February 1998, Week 1
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January 1998, Week 1
December 1997, Week 5
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December 1997, Week 3
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November 1997, Week 5
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November 1997, Week 3
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December 1995, Week 5
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