Nancy Reagan Presses The Fight
Former first lady to make most public endorsement of stem cell research.
The Sacramento Bee, CA
By Laura Mecoy -- Bee Los Angeles Bureau
Published 2:15 am PDT Saturday, May 8, 2004

BEVERLY HILLS - It's as if the coach's wife showed up for the opposing team's pep rally.

The wife of former President Reagan is set to be the star attraction at tonight's $2 million fund-raiser to pay for
embryonic stem cell research - an emerging science opposed by her husband's allies in the anti-abortion movement and
the GOP.

It will be Nancy Reagan's most public endorsement of the controversial studies scientists say hold the best hope of
curing myriad f ailments, including Alzheimer's, the disease ravaging her husband.

By spurning opponents' objections to research using embryos, the former first lady has become a potent weapon in a
burgeoning challenge to President Bush's 2001 limits on federal funding for stem cell studies.

"She's been very reluctant to get in the public eye," said Doug Wick, a Reagan family friend who enlisted her help on
the issue. "She knows what that means. But she's so genuinely committed to stem cell research."

The "Gala Tribute to Nancy Reagan" tonight is part of the Juvenile Diabetes Research Foundation's $20 million fund-
raising drive for studies of these "master cells" that can transform into any cell in the human body.

The science is in its infancy. But other disease advocacy groups and patients' families have given millions to
universities and stem cell programs in the hope the research can lead to cures for spinal-cord injuries, lupus,
Parkinson's and other illnesses.

More than 200 House members signed a letter asking Bush to reverse his stem cell funding limits, and the president's
ruling promises to become a contentious issue in November's election.

Democratic presidential candidate John Kerry vowed to repeal it because "100 million Americans ... could eventually
benefit" from stem cell research.

In California - the first state to sanction stem cell studies - patients, their families and scientists hope to use
state dollars to bypass the president's restrictions if, as expected, their $3 billion, 30-year stem cell bond measure
gets on the November ballot.

"The California initiative could make an amazing difference because the scientists and the institutions in the state
are ... among the best in the world," said Evan Snyder, a leading stem cell researcher.

Snyder moved from Harvard University to San Diego's Burnham Institute in 2002, shortly after California enacted laws to
promote and regulate the research.

"The law made California a real safe haven for stem cell research," Snyder said.

California has been a leader in the field, with the most biotechnology firms, outstanding researchers and universities
starting to raise millions to pay for stem cell studies.

New Jersey followed California's lead by adopting a similar stem cell law in January. Its governor then proposed a $60
million public-private stem cell research partnership.

Harvard launched a $100 million fund-raising drive last month, and one of its top researchers recently developed 17
stem cell lines with private contributions. Privately funded research is under way in Minnesota, Wisconsin and other
states as well.

Researchers first isolated and cultivated human embryonic stem cells in 1998. They derive the cells from extra embryos
created for in-vitro fertilization that would otherwise be discarded.

But abortion foes, many of whom oppose in-vitro fertilization, say the research violates the sanctity of life.

"We didn't like the idea of the Germans using Jews for experiments during World War II," said Camille Giglio,
California Right to Life co-founder and director. "Why is it now all right to use embryos?"

With Bush's election in 2000, critics of stem cell research gained a supporter in the White House to make the decision
about funding this research.

Supporters of stem cell research, including many in California, flooded Capitol Hill and the White House with calls and
letters.

Among them were two influential Southern California couples chairing tonight's fund-raiser: Wick, the Reagan family
friend, his wife, Lucy Fisher, and Jerry and Janet Zucker.

Wick and Fisher have a 13-year-old daughter, Tessa, who was diagnosed with juvenile diabetes in 1999. The Zuckers'
daughter, Kate, received the same diagnosis six months later.

"Driving home that night from the doctor's office, Jerry and I promised Kate that we were going to do everything in our
power to cure this so she wouldn't have to face it all of her life," Janet Zucker recalled.

The two couples knew one another from working in the movie industry. Wick is the Academy Award-winning producer of
"Gladiator," and Zucker directed "Ghost." Their wives also are producers.

They created CuresNow, a lobbying and educational organization for stem cell research, and enlisted Nancy Reagan's
help.

Nancy Reagan, 82, declined to be interviewed. But Wick said she was their secret weapon.

"The notion that Nancy Reagan, who has such great credibility, was supporting this issue was quite startling to
people," he said.

Giglio said the former first lady "undermined an awful lot of things pro-life people have tried to do."

Nancy Reagan worked behind the scenes to help block legislation to criminalize therapeutic cloning, a process that
could avoid the rejection problems plaguing today's transplant programs.

The measure was critical for CuresNow founders. Rejection of new insulin-producing cells is the biggest hurdle in
experimental transplants that have cured about half of diabetic subjects.

Nancy Reagan's quiet persuasion also helped win over some leading abortion foes such as conservative Utah Sen. Orrin
Hatch.

But she had limited success with Bush. The president, in a nationally televised address Aug. 9, 2001, said she'd
written him about her husband's struggle with Alzheimer's. But he had to encourage respect for life.

So he sought to strike a compromise. He limited federal money to research on stem cells that had been harvested. There,
he said, the "life and death decision has already been made."

Of the 78 stem cell lines eventually qualifying for federal funding, only 19 have been made available to researchers
because of difficulties in developing them. Four more might be available soon. But all the lines were developed atop
mouse feeder cells, further limiting their use in human treatments.

"This ruling by the president has essentially limited, if not stopped ... stem cell research in most places in the
country," Nobel laureate Paul Berg said.

Bush held out hope for great scientific progress with adult stem cells, which don't require an embryo's destruction.

But scientists say the adult cells don't have the ability to turn into as wide a range of cells as embryonic stem cells
do.

"We don't know enough about adult, embryonic or germ stem cells to know if we should go down one road or another," said
Daniel Perry, president of the Coalition for the Advancement of Medical Research. "We should go down all the roads ...
to find cures as soon as possible."

In Sacramento, the president's ruling and congressional attempts to outlaw therapeutic cloning spurred state Sen. Debra
Ortiz, D-Sacramento, to action.

She wrote bills promoting and regulating stem cell research that were signed into law in 2002.

She then wrote a bill for a bond measure to pay for the research. The bill never made it out of committee because of
the state's budget crunch.

Stem cell researchers encouraged her to enlist the CuresNow founders in launching a signature-gathering campaign to put
the bond on the ballot.

"I flew to L.A. and into a room where there were 40 people I didn't know," Ortiz said. "They took it from there."

The CuresNow founders linked with Robert Klein, a Palo Alto parent of a diabetic child, who had an expertise in bond
measures.

The stem cell measure would cost taxpayers an estimated $6 billion over 30 years. But Klein designed it to pay for
itself in the first five years to give the state's economy time to recover.

The bond's promoters say it could pay for itself by lowering health care costs and generating tax revenues from
economic development and royalties on patents, if the research results in treatments.

Abortion foes, who are starting to organize against the measure, contend the bond offers pie-in-the-sky promises.

"The scientists and people who have an eye on this huge fund of money are mistreating naive people who really believe
their rhetoric that a cure is just around the corner," said Carol Hogan, California Catholic Conference spokeswoman.

She said the other side has the advantage in the campaign because it has more money, and it can use sick children and
relatives of those suffering from serious illnesses to appeal to voters.

At tonight's fund-raiser, one of the most prominent Parkinson's disease patients, actor Michael J. Fox, will present
Nancy Reagan with an award.

She is expected to accept it with her first public comments on the research that has put her at odds with her husband's
allies.

Her friends at CuresNow are hoping she eventually will speak in support of the bond measure.

But they know it would be an unprecedented leap back into politics for a former first lady who has limited her public
role since leaving the White House.

"I don't know if she will get involved," Wick said. "I think it's one step at a time."

About the Writer
---------------------------

The Bee's Laura Mecoy can be reached at (310) 546-5860 or [log in to unmask]

SOURCE: Sacramento Bee, CA - May 8, 2004
http://www.sacbee.com/content/politics/story/9221043p-10146308c.html

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Nancy Reagan Reiterates Support For Human Embryo Research
Associated Press

Posted on Sun, May. 09, 2004

BEVERLY HILLS, Calif. - Former first lady Nancy Reagan walked back into the hot glare of the political spotlight
Saturday night when she renewed her endorsement of human embryonic research at a star-studded fund-raiser for the
controversial work that is opposed by many political conservatives.

Reagan, who was introduced by actor Michael J. Fox, was heartily applauded by a Hollywood crowd often more associated
with Democratic politics, abortion rights and other liberal causes.

The research is opposed by many anti-abortion groups because it involves the destruction of days-old human embryos that
are usually donated by fertility. President Bush signed an executive order in 2001 limiting research to the embryonic
stem cell lines already in existence

Reagan and others believe the use of stem cells taken from the embryos will eventually lead to cures for a wide range
of illnesses, including the memory-robbing Alzheimer's disease that her husband, former President Ronald Reagan,
suffers from and the Parkinson's disease that afflicts Fox.

"Ronnie's long journey has finally taken him to a distant place where I can no longer reach him," she said. "Because of
this I'm determined to do whatever I can to save other families from this pain. I just don't see how we can turn our
backs on this."

The Republican former first lady became one of the first conservative-minded public figures to support human embryo
research when she came out in favor it more than three years ago.

"I think it's really unique, remarkable and singular to step forward and support this as she does," said singer James
Taylor, who performed Saturday night at the benefit for the Juvenile Diabetes Research Foundation.

Taylor even pecked Mrs. Reagan on the cheek at the end of the fund-raiser, which was expected to raise $2 million.

SOURCE: Associated Press / Monterey County Herald, CA - May 9, 2004
http://www.montereyherald.com/mld/montereyherald/news/politics/8625102.htm

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PRESS RELEASE: The Juvenile Diabetes Research Foundation Pays Tribute to Nancy Reagan at the 'Finding a Cure ... A Love
Story' Gala to Benefit Stem Cell Research

Michael J. Fox Presents Former First Lady with Award

LOS ANGELES, May 8 /PRNewswire/ -- The Juvenile Diabetes Research Foundation (JDRF) paid tribute to former first Lady
Nancy Reagan today at the "Finding a Cure ... A Love Story" event to benefit stem cell research, which raises hopes for
the treatment of diabetes and other chronic diseases.

Michael J. Fox, who has Parkinson's disease, presented the tribute award to Mrs. Reagan for her commitment to the fight
for a cure while witnessing daily, the ravaging effects of Alzheimer's on her beloved husband.  Mrs. Reagan joined more
than 100 Nobel Laureate scientists to endorse stem cell research as the future for many cures.

The gala marks an important milestone in the unification of diseases that can benefit from stem cell research, which is
presently the most promising approach to finding a cure for Type 1 diabetes.  During the gala, Harrison Ford and
Calista Flockhart read letters from Presidents Ford, Carter and Clinton all voicing support for Mrs. Reagan's
commitment to finding a cure.

"Nancy Reagan has inspired all of us with her complete devotion to her husband and the often forgotten task of the
daily caregiver.  For the millions of Americans who struggle with the disease of a family member, her trusted voice has
brought new hope to the fight for stem cell research," said honorary co-chairman Lucy Fisher.

Master of Ceremonies Larry King welcomed and entertained guests throughout the evening and introduced speakers Dustin
Hoffman and Leeza Gibbons.  Dustin Hoffman presented Novo Nordisk with the Angel Award for its leadership in diabetes
care.  Leeza Gibbons, who has long fought for a cure for juvenile diabetes, gave remarks on stem cell research.  Music
legend James Taylor
performed for guests following a children's choir that sang Promise to Remember Me.

The gala is JDRF's first fundraising event specifically in support of stem cell research, from which many researchers
believe the cure for diabetes, Parkinson's, Alzheimer's and other diseases may be identified.  Approximately 128
million individuals could be successfully treated or cured by stem cell research.

"JDRF is one of the leading health organizations supporting and funding stem cell research.  To support this, JDRF
created a new Stem Cell Development Fund which seeks to raise $20 million for this important field of research," said
Peter Van Etten, president of JDRF.  "Companies like Novo Nordisk are making it possible to reach our goals of finding
a cure for more than 128 million people."

Presented by Dustin Hoffman, Novo Nordisk received the Angel Award for their continued support in stem cell research.
"Novo Nordisk is proud to be recognized with the Angel Award from the Juvenile Diabetes Research Foundation for our
dedication to diabetes care and research and continued support of stem cell research.  As a world leader in diabetes
care, Novo Nordisk is dedicated to improving the lives of people with diabetes, and finding a cure is part of our
vision," said Martin Soeters, president of Novo Nordisk Pharmaceuticals, Inc.

About JDRF

The mission of JDRF is to find a cure for diabetes and its complications through the support of research.  The leading
charitable underwriter and advocate for juvenile (Type 1) diabetes research worldwide, JDRF is the leading health
organization that has publicly supported and funded stem cell research.

About Novo Nordisk

Novo Nordisk is a healthcare company and a world leader in diabetes care. The company has the broadest diabetes product
portfolio in the industry, including the most advanced products within the area of insulin delivery systems. In
addition, Novo Nordisk has a leading position within areas such as haemostasis management, growth hormone therapy and
hormone therapy for women.
Novo Nordisk manufactures and markets pharmaceutical products and services that make a significant difference to
patients, the medical profession and society. With headquarters in Denmark, Novo Nordisk employs approximately 18,800
full-time employees in 69 countries, and markets its products in 179 countries. Novo Nordisk's B shares are listed on
the stock exchanges in
Copenhagen and London. Its ADRs are listed on the New York Stock Exchange under the symbol 'NVO'. For US information,
visit http://www.novonordisk-us.com ; for global information, visit http://www.novonordisk.com

About Entertainment Industry Foundation

Celebrating 63 years of giving, the Entertainment Industry Foundation is the philanthropic heart of the entertainment
industry. The Entertainment Industry Foundation has distributed hundreds of millions of dollars -- and provided
countless hours -- to support charitable initiatives that address some of the most critical issues facing our society.

SOURCE Juvenile Diabetes Research Foundation

Web Site:

http://www.jdrf.org

http://www.novonordisk-us.com

http://www.novonordisk.com

SOURCE: PR Newswire (press release) - May 8, 2004
http://tinyurl.com/2wpyh

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