Plonk?
C/E

--- "M.Schild" <[log in to unmask]> wrote:

>   Keep in the PINK to avoid Parkinson's
>   Keeping fit and avoiding diabetes could also help to
> protect you from
> Parkinson's disease
>
>
>
>
> A team of scientists at Heriot-Watt University in
> Edinburgh have discovered a
> mechanism linking the development of Parkinson's disease
> to people who have
> already developed Type II Diabetes.
> In recent months researchers in Finland have demonstrated
> that your risk of
> developing Parkinson's is approximately doubled if you
> develop Type II
> Diabetes, while American researchers have shown that if
> you exercise
> regularly (which decreases your chance of getting
> diabetes) you are also half
> as likely to get Parkinson's, but no-one was sure why.
> The Heriot-Watt team, led by Professor James Timmons,
> Professor of Exercise
> Biology at the School of Life Sciences, have discovered
> that the biochemical
> changes brought about by diabetes switch off a gene
> called the PINK1 gene,
> and loss of function of this gene is a established cause
> of Parkinson's.
> The team made their discovery by comparing 200 tissue
> samples donated by
> volunteers, many of whom have been diagnosed with Type II
> Diabetes.
>
>  They found that the Diabetes patients produce less of
> the product of the
> PINK1 gene, and are thus more liable to develop
> Parkinson's, and that this
> may happen because it is the immediate neighbour of a
> known Diabetes gene
> (DDOST).
> Professor Timmons said, "Loss of PINK1 isn't the only
> cause of Parkinson's,
> but discovering this direct link between Diabetes and
> regulation of the PINK1
> gene is the first example of a molecular mechanism
> potentially linking the
> two terrible illnesses, rather than just a statistical
> association in
> population studies.
>
>  The next step is to find exactly how loss of PINK1
> actually causes the
> neuronal cell death, and hence Parkinson's.
> "It also helps to demonstrate that, in contrast to the
> traditional image of
> whether you have a 'healthy' gene sequence or not, in
> fact your 'healthy'
> genetic sequence can 'switched off' over time, leading to
> the development of
> illness, and importantly that these changes can be caused
> by external
> influences such as lifestyle choices."
> The next step for the team is to understand the
> biochemical process which
> actually causes the PINK1 (and related Diabetes gene) to
> be switched off, in
> the hope that they can find ways to tackle both diseases.
>
>  Meanwhile their recommendation is to make the lifestyle
> choices including
> taking regular exercise, which can help to prevent
> Diabetes and thereby
> potentially reduce your risk of developing Parkinson's.
>
>
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