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PARKINSN  November 2007, Week 2

PARKINSN November 2007, Week 2

Subject:

Re: Cough Medicine Fights Dyskinesias In Parkinson's

From:

Mary Ann Ryan <[log in to unmask]>

Reply-To:

Parkinson's Information Exchange Network <[log in to unmask]>

Date:

Fri, 9 Nov 2007 08:12:54 -0500

Content-Type:

text/plain

Parts/Attachments:

Parts/Attachments

text/plain (77 lines)

This very medication has been contraindicated for PWP for years.  It
inhibits movement - my guess would be that it is probably a dopamine
depleter.
---------
Mary Ann
www.bentwillowfarm.org
Subject: Cough Medicine Fights Dyskinesias In Parkinson's


> Cough Medicine Fights Dyskinesias In Parkinson's
> ScienceDaily (Nov. 9, 2007) — A cough suppressant and a drug tested as a
> schizophrenia therapy curb the involuntary movements that are disabling
> side
> effects of taking the Parkinson's disease medication levodopa, Portland
> scientists have found.
>
>
> Dextromethorphan, used in such cold and flu medications as Robitussin,
> Sucrets, Triaminic and Vicks, suppresses dyskinesias in rats, researchers
> at
> Oregon Health & Science University and the Portland Veterans Affairs
> Medical
> Center found. Dyskinesias are the spastic or repetitive motions that
> result
> from taking levodopa, or L-dopa, over long periods.
> The researchers also found that BMY-14802, a drug previously tested in
> people
> with schizophrenia and found to be safe -- although not effective in
> treating
> schizophrenia symptoms -- suppressed dyskinesias in rats more effectively
> than dextromethorphan did, suggesting that BMY-14802 might work to block
> dyskinesias in people with Parkinson's.
> "These results were unexpected, but very exciting," said the study's lead
> author, Melanie A. Paquette, Ph.D., postdoctoral fellow in the Department
> of
> Behavioral Neuroscience, OHSU School of Medicine, and the PVAMC. "We have
> filed a patent for the use of BMY-14802 for dyskinesias and we hope to get
> funding to begin human trials very soon."
> The study, titled "Differential effects of NMDA antagonists and sigma
> ligands
> on L-dopa-induced behavior in the hemiparkinson rat," is being presented
> during a poster session today at Neuroscience 2007, the 37th annual
> Society
> for Neuroscience conference in San Diego.
> The results also affirm the value of the rat model for dyskinesias that
> Paquette's team used in the study. Previous studies by other researchers
> have
> shown the drug amantadine already is effective in treating dyskinesias in
> both humans and rats, and dextromethorphan's effectiveness against the
> condition in rats provides more data supporting the use of the model.
> "Basically, these two drugs work to block dyskinesias in both humans and
> rats,
> and that means the rats are a good model to screen potential drug
> treatments
> for humans with dyskinesias," Paquette said.
> But BMY-14802, which is an antagonist at sigma-1 receptor sites in the
> brain, "worked much better than dextromethorphan," an antagonist at
> N-methyl-D-aspartate (NMDA) receptors.
> "There's something special about BMY-14802," Paquette explained. "The
> effect
> on dyskinesias is really striking and I've repeated it several times, so
> it's
> a reliable finding. It's a very exciting result."
> The study was funded by the National Institute on Drug Abuse and the
> National
> Institute of Neurological Disorders and Stroke, National Institutes of
> Health, and the U.S. Department of Veterans Affairs.
> Adapted from materials provided by Oregon Health & Science University.
>
> ----------------------------------------------------------------------
> To sign-off Parkinsn send a message to:
> mailto:[log in to unmask]
> In the body of the message put: signoff parkinsn

----------------------------------------------------------------------
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December 1998, Week 5
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December 1997, Week 5
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December 1997, Week 3
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December 1995, Week 5
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