A Key to the Blue Rosetta Stone
By Sharon Le Blanc 9/30/08
A Greek key beta-barrel protein looks like a Greek pottery design, and a jelly roll is a Greek Key with an extra swirl. For the most part Greek key beta-barrel proteins have a tyrosine or blue copper protein corner. There are also reverse corner Greek key beta-barrel proteins. (The Tyrosine Corner: A feature of most Greek Key beta-barrel Proteins by Jane and David Richardson et al. 1994).  In SCOP, you can find a list all Greek Key beta-barrel proteins.
Greek key beta-barrel proteins are exact puzzle pieces involved in protein folding with an expected blue copper ion. As I understand it, when the metal ion is smaller than expected the puzzle pieces become loose or unstable, and when the metal ion is larger than expected, the puzzle pieces bend toward the larger metal ion and misfold. (Metal Ions in Biochemistry by PK Bhattacharya 2005). 
Copper has an empirical radius of 135 picometres. Tellurium has an empirical radius of 140 picometres. (Both are within an accuracy of 5 picometres.)  Probing Protein Stability with Non-natural Amino Acids by Nediljko Budisa and Greta Pifat 1997 describes tellurium and protein misfolding.
The Blue Rosetta Stone refers to Lytico- Bodig Disease or Guamanian Amyotrophic Lateral Sclerosis/Parkinsonism/Dementia Complex (ALS/PDC) which has similar features to ALS, Parkinson's Disease and Alzheimer's Disease and is considered the Rosetta Stone of neurodegenerative diseases. All three diseases involve protein misfolding.
The indigenous Chamorro people of Guam, who uniquely suffer this disease, had a tradition of eating Flying Fox (Fruit Bat) soup of Pteropus mariannus and Pteropus tokudae, with blue coconut crab dumplings, made with flour from the seeds of the cycad Micronesia plant.
Blue Copper Proteins or cupredoxins absorb light at 600 nm due to their sulfur to copper charge transfer (S-Cu). Class I T1Cu proteins include: amicyanin, plastocyanin, and pseudoazurin.  Class II T1Cu proteins include: Azurins.  Type III T3Cu includes hemocyanin and tyrosinase. Binuclear Copper A Centres include: Cytochrome C oxidase and nitrous-oxide reductase. Other blue copper proteins include tyrosine, insecticyanin, crusticyanin, and sandercyanin.  Deoxyhemocyanin is colorless but absorbs ultraviolet light. Ceruloplasmin is a blue copper protein transporter. Cupredoxins are Greek Key Beta-Barrel proteins.


Tellurium is used in ceramics to make the color ultramarine blue. Tellurium is also detected with ultraviolet light, with colors in the ultraviolet range that man cannot see. It is chemically related to selenium and sulfur and gives a greenish-blue color flame when burned. Tellurium smells like garlic, and the antagonist of tellurium is selenium, which prevents cancer.
Tellurium is found in relatively large amounts in the human body, 600 mg. Water-soluble tellurite's and tellurates are absorbed through the gastrointestinal tract. Fumes of tellurium dioxide may be absorbed readily through the lungs and volatile tellurium esters through the skin. Tellurium in the body is unevenly distributed with the greatest proportion in the bones, with only a small amount in soft tissue (about 50mg). (Alzheimer's Disease, Kuf's Disease, Tellurium and Selenium by Andrew J. Larner 1996). Parkinson's disease has been linked to blunt trauma.
Tellurium is found in water, spring water, sea water, and vegetation. The last USA tellurium mines (Asarco Mining) are found in Amarillo Texas. Globally tellurium is found in tellurium-rich ferromanganese crusts that occur throughout the ocean basins at water depths of about 400 to 4000 meters, or where the ocean floor has risen to the surface,(Global Occurrence of Tellurium-rich Ferromanganese Crusts and a Model for the Enrichment of Tellurium by James R Hein, et al 2002.), like on the island of Guam. Choral contains tellurium. According to Selenium and Tellurium by Robert D Brown world production of tellurium is about 220 tons a year. Tellurium is skimmed from copper and is a waste product of lead electroplating. Tellurium is used as a coloring agent in ceramics, china, porcelains, enamels, glass, silverware, and in the making of coins. Tellurium is added to lead to improve its strength and added to steel and copper to make these metals more workable. Tellurium can be found in the inner workings of copier machines. Tellurium is used in the vulcanization of rubber. Tellurium was used to crack petroleum to make diesel fuel, gasoline and other petroleum products. 
Tellurium is also found in clays like Mortmorillonite which is the main constituent of the volcanic ash weathering product bentonite. Tellurium is found in Kaolin, Fuller's Earth, Diatomite and Diatomateous Earth. Mortmorillonite is used to seal and plug water wells and oil wells. It is used as a component of drilling mud. It is used as a component of earthen dams and levees and to prevent the leakage of fluids, and is used as a protective liner for landfills. Mortmorillonite is used in cosmetics and is used in animal feeds as an anti-caking agent. Mortmorillonite is used in paper making, paper filling, paper coating and in aquatic soil. Bentonite is used in sewage treatment plants and in pet litter. Bentonite is used to spread pesticides.  Kaolin is found in chalk and is used in medicines such as vaccines. Diatomite is used in explosives. Diatomateous earth is used in chlorinated pools and is used by beekeepers to ward off beetles.

In 2005 the World Health Organization reported that Bentonite production was about ten and a half million tons a year, Fuller's Earth another four million tons, Kaolin another forty three million tons.
Blue-Green Cyanobacteria have a symbiotic relationship with the cycad Micronesia and produce the BMAA toxin that binds with metals. Cyanobacterial plastocyanin is a Greek Key beta-barrel protein. Cyanobacteria can be tellurite resistant, or able to live on and incorporate tellurium within themselves. BMAA toxin has been found in Canadians with Alzheimer's Disease as well as in ALS/PDC (Occurrence of beta-methylamino-l-alanine (BMAA) in ALS/PDC patients from Guam by Murch SJ, Cox PA, Banack Sa, Steele JC, Sacks OW).  In 1996 Dr. Andrew J. Larner wrote his theory "Alzheimer's Disease, Kuf's Disease, Tellurium and Selenium. At present, the Blue Cycad Butterfly Theclinesthes onycha is defoliating and damaging the cycad Micronesia.
Blue-Green Aspergillus flavus lives on cycad seeds. Aspergillus oryzae is a melanizing fungus that produces aflatoxin and is a hyper producer of L-Dopa, a useful drug in the treatment of Parkinson's Disease. Aspergillus terreus is tellurite resistant and produces Lovastatin which can unmask Parkinson's Disease (Parkinsonism Unmasked by Lovastatin by Th. Muller, W. Kuhn, D. Pohlau and H.Przuntek). In "Ultrastructure and Significance of Micro-organisms Found in the Formalin-fixed Brain from a Case of Parkinsonism" by S. Roy and L Wolman there is a picture of a club shaped organism containing spores. Aspergillus Versicolor is blue and club shaped and causes onchymycosis or a thickening of toenails. My Parkinsonian has thick toenails. Agglutinin is a protein found in cows milk that causes it to clump. Casein aggregates are found in milk clotting. Tellurium is found in dairy products. Agglutination is the clumping of cells such as bacteria or red blood cells in the presence of an antibody. Allergic reactions occur where cells become more compacted. Parkinsonians tend to have allergies. Hemagglutinin, Influenza Virus HA1 is a jellyroll Greek Key Beta-barrel protein. Hemagglutin (HA)-Synphillin-1 interracts with alpha-synuclein to form Lewy Bodies. (Ubiquitylation of synphilin-1 and alpha-synuclein by SIAH and its presence in cellular inclusions and Lewy Bodies imply a role in Parkinson's disease by Esti Liani et al., 2004).




Patients recovering from von Economo Disease developed Parkinsonism. At first many confused Encephalitis Lethargica with the Spanish Flu.
According to the American Naturalist "Epidemic, Primary Virus Infections of the Central Nervous System of Man" by Peter Olitsky 1946, Von Economo's Disease or Encephalitis Type A is sometimes a sequela of the anti-smallpox vaccination and of other viral infections, such as influenza.  Localized epidemics of Australian "X" encephalitis arose in 1917-1918, continuing to 1926; the disease was found to be caused by a virus Japanese B or louping-ill virus.
The smallpox vaccine virus is transmitted by sex.(Morbidity and Mortality Weekly 2007.) Tellurium was used in those days to treat Syphilis. Vaccinia virus is an enveloped virus with a capsid, belonging to the poxvirus family, and is well-known for its role as a vaccine that eradicated the smallpox disease. It was isolated from horses. Many viruses, including influenza, have viral envelopes covering their protein capsids. Nucleoplasmin-like/VP(viral coat and capsid proteins) are jellyroll Greek Key Beta-barrel proteins.
Yellow Fever Vaccination, Simple or Associated with Vaccination Against Smallpox, of the Populations of French West Africa by the Method of Pasteur Institute of Dakar by Maurice Peltier describes how powdered Kaolin was used with monkey brain powder to deliver the Smallpox Vaccination.  "Intuition and Autism: a possible role for Von Economo neurons by John Allman, Karli Watson, Nicole Tetreault and Atiya Hakeem describes a connection between  Autism and Von Economo disease. The MMR vaccine include live viruses. Before reconstitution the freeze dried or lyophilized vaccine is a light yellow compact crystalline plug. Kaolin is used in medical plugs. The MMR vaccine has been linked to Autism. Both vaccines would contain varying amounts of tellurium if Kaolin is used.  Measles and Mumps are Paryxomyviruses that have nucleocapsids. Rubella is also an enveloped virus with a capsid, a togavirus, a member of the Togaviridae family, which includes Equine Encephalitis. 
Parkinsonism can be a sequela of Japanese B Encephalitis and von Economo encephalitis. Fruit bats can be infected and the vector is a Culex tritaeniorhynchus or Culex mosquito. Japanese B Encephalitis is an arbovirus that is found in the Mariana Islands which include Guam. Arboviruses are transmitted to man mainly via blood sucking arthropods, like tics, mosquitoes or other insects. The (TBE) or Pre-existing tick-borne encephalitis vaccine is used to treat the Japanese encephalitis virus.

In "Neurodegenerative Diseases: Occupational Occurrence and Potential Risk Factors, 1982 through 1991" by Paul Schulte et al., the number one occupation for Parkinson's Disease, per death certificates, minus the usual pesticide, MPTP, and Manganese or metal exposure people, were Secondary Education School Teachers.  Kaolin is used in chalk and Aspergillus lives in chalk. Tellurium is also used in ultramarine blue which is the color of ceramic blackboards. Parkinson 's disease tends to be near where people drink well water and Mortmorillonite or Bentonite is used to patch drinking wells. In 1999 Alaskan airline attendants sued the airlines for a Parkinson 's disease they attributed to the hydraulic fluid. Tellurium is found in petroleum products and Aspergillus is found in hydraulic fluid . 
Aspergillus crystallinus (grupa versicolor) produces an aflatoxin. I wonder if the term crystallinus has anything to do with the jellyroll Greek Key beta-barrel protein y-crystallin domain 1 or domain 2 . AlphaB-Crystallin  is involved in an aggressive form of  breast cancer, which has also been linked to aflatoxin. Dogs are able to smell cancer. If you look at the Silent Spring Institute Map of Breast Cancer clusters in Massachusetts they tend to coincide with Aquaculture Facilities that use Bentonite. 
Crystallin is also involved with Ewing's Sarcoma that is associated with a cytomegalovirus, a herpesvirus with a nucleocapsid, found in breast milk, that can also contain tellurium. There was a recent outbreak of Ewing's Sarcoma at Cape Cod, Massachusetts. Gamma-Crystallin-like is a Greek Key Beta-barrel protein. Azurin preferentially enters cancer cells more than normal cells.
I often wonder if the cigarette smoking that causes cancer is more due to the tellurium in the paper, than the tobacco mosaic virus.
Which bring us to ALS and Cu,Zn Superoxide dismutase which is a Greek Key Beta-barrel protein. The most commonly mutated gene for Familial ALS or Lou Gehrig's disease, encodes superoxide dismutase type 1 (SOD1), a dimeric metalloenzyme rich in beta-sheet structure and contains copper and zinc binding sites.
TDP-43 (Thymidine Diphosphate) is the disease protein found in sporadic cases of ALS and Guamanian ALS/PDC. (TDP-43 is deposited in the Guam Parkinsonism-Dementia Complex Brains by Hasegawa M, et al.). In "Simultaneous Determination of Thymidylae and Thymidine Diphosphate by Capillary Electrophoresis as a Rapid Monitoring Tool for Thymidine Kinase and Thymidylate Kinase Activities" by Tzeng HF and Hung HP 2005, a radioactive method for determining thymidine kinase and thymidylate kinase from the White Spot Syndrome Baculovirus is described. White Spot Syndrome Virus infects crabs, the Blue Coconut Crab, shrimp and trout. 

AB Vector of California is a Protein-Folding Company that provides baculoviruses for the study of protein folding in Parkinson's, Alzheimer's and Lou Gehrig's Disease. Baculovirus p35 protein is a Greek Key Beta-Barrel protein. 
There was a cluster of ALS in Middleborough Massachusetts, which is home to the blue crab of Cape Cod. In Middleborough there is the Middleboro Lead Electroplating Company (tellurium is a waste product of lead electroplating) and the Great Brook Trout farm. A landfill was dug up and the South Weymouth Naval Station is nearby.
Amarillo Texas had a high cluster of ALS. The Amarillo Army Airfield is located near the Pantex Army Ordinance Plant which produced bombs and ammunition and now produces nuclear weapons. Diatomite contains tellurium. Amarillo Texas is home to The Amarillo Airforce Base and ASARCO tellurium mines. The city of Amarillo Texas gets its water supply from Lake Meredith, a lake stocked with Blue Walleye, blue catfish, and rainbow trout.
The Persian War Gulf Veterans are coming back with many cases of ALS. Mortmorillonite is used in petroleum drilling. The Persian Gulf is famous for its shrimp.
Arboviruses are viruses transmitted by arthropods, or arthropod-borne viruses. The Blue Coconut Crab is an arthropod. Arthropods are able to transmit the virus upon biting and allowing the virus to enter the bloodstream. I don't know if ALS is from eating the shellfish, or from an insect attacking the shellfish. I do know there are also blue insects.
The Cycad Blue Butterfly is defoliating the cycad Micronesia of Guam. Cycads are pollinated by beetles. The Mason bee, Osmia lignaria, also known as the blue orchard bee, is an efficient pollinator for fruit. 
Butterflies and Bats are also pollinators. They are attracted to blue, and have an ultraviolet vision that mankind does not, that enables them to navigate and find the flowers, pollen, and nectar they search out. They are attracted to the ultraviolet range of Tellurium. Bees are also more prone to take exception to certain odors than to color.
Beekeepers use Diatomaceous Earth to prevent ants and hive beetles, Aethina tumida, from getting into the hive. Stonebrood is a fungal disease caused by Aspergillus fumigatus, Aspergillus flavus and Aspergillus niger.
Dicistroviridae are a family of insect-infected viruses. Insects commonly infected are aphids, leafhoppers, flies, bees, ants and silkworms. Many Dicistroviridae were originally placed in the family Picornaviridae. Dicistroviridae includes the Israel Acute Paralysis Virus. 

Picornaviridae are a family of viruses containing a capsid. Maybe Bee Colony Collapse Disorder is from a tellurite resistant Bee Virus. Maybe it is a paralyzing disease like ALS. 


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