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Agreed. I think if I were considering DBS now I would wait a little
longer. My 2 DBSs helped tremors but little else and this has got to be
easier surgery.
Ray
Rayilyn Brown
Director AZNPF
Arizona Chapter National Parkinson Foundation
[log in to unmask]
--------------------------------------------------
From: "Nic Marais" <[log in to unmask]>
Sent: Friday, March 20, 2009 12:59 AM
To: <[log in to unmask]>
Subject: Re: spinal cord stimulator for PD
> Now this looks promising...
>
> Nic 57/15
>
> On Fri, Mar 20, 2009 at 4:46 AM, rayilynlee <[log in to unmask]> wrote:
>
>> Novel spinal cord stimulator sparks hope for Parkinson's disease
>> treatment
>>
>> DURHAM, NC - A novel stimulation method, the first potential therapy to
>> target the spinal cord instead of the brain, may offer an effective and
>> less
>> invasive approach for Parkinson's disease treatment, according to
>> pre-clinical data published in the journal Science by researchers at Duke
>> University Medical Center.
>>
>> Researchers developed a prosthetic device that applies electrical
>> stimulation to the dorsal column in the spinal cord, which is a main
>> sensory
>> pathway carrying tactile information from the body to the brain. The
>> device
>> was attached to the surface of the spinal cord in mice and rats with
>> depleted levels of the chemical dopamine - mimicking the biologic
>> characteristics of someone with Parkinson's disease along with the
>> impaired
>> motor skills seen in advanced stages of the disease.
>>
>> When the device was turned on, the dopamine-depleted animals' slow, stiff
>> movements were replaced with the active behaviors of healthy mice and
>> rats.
>> Improved movement was typically observed within 3.35 seconds after
>> stimulation.
>>
>> "We see an almost immediate and dramatic change in the animal's ability
>> to
>> function when the device stimulates the spinal cord," says senior study
>> investigator Miguel Nicolelis, M.D., Ph.D., the Anne W. Deane Professor
>> of
>> Neuroscience at Duke. "Moreover, it is easy to use, significantly less
>> invasive than other alternatives to medication, such as deep brain
>> stimulation, and has the potential for widespread use in conjunction with
>> medications typically used to treat Parkinson's disease."
>>
>> Researchers tested mice and rats with acute and chronic dopamine deficit
>> using varying levels of electrical stimulation and in combination with
>> different doses of dopamine replacement therapy, also known as
>> 3,4-dihydroxy-L-phenylalanine or L-DOPA, to determine the most effective
>> pairing.
>>
>> When the device was used without additional medication, Parkinsonian
>> animals were 26 times more active. When stimulation was coupled with
>> medication, only two L-DOPA doses were needed to produce movement
>> compared
>> to five doses when the medication was used by itself.
>>
>> "This work addresses an important need because people living with
>> Parkinson's disease face a difficult reality - L-Dopa will eventually
>> stop
>> managing the symptoms," explains Romulo Fuentes, a postdoctoral fellow at
>> Duke University and lead author of the study. "Patients are left with few
>> options for treatment, including electrical stimulation of the brain,
>> which
>> is appropriate for only a subset of patients."
>>
>> While deep brain stimulation (DBS) and other experimental treatments
>> attack
>> the disease at its origin - in the brain - Nicolelis and team took a
>> different approach. The concept for the device began when researchers
>> made a
>> surprising connection with another neurological condition.
>> "It was a moment of sudden insight," explains Nicolelis. "We were
>> analyzing
>> the brain activity of mice with Parkinson's disease and suddenly it
>> reminded
>> me of some research I'd done in the epilepsy field a decade earlier. The
>> ideas began to flow from there."
>>
>> The rhythmic brain activity in the animals with Parkinson's disease
>> resembled the mild, continuous, low-frequency seizures that are seen in
>> those with epilepsy. One effective therapy for treating epilepsy involves
>> stimulating the peripheral nerves, which facilitate communication between
>> the spinal cord and the body. Researchers took that concept and developed
>> a
>> modified approach for a Parkinson's disease model.
>> Nicolelis says that the low frequency seizures, or oscillations, seen in
>> the animal model of Parkinson's disease have been observed in humans with
>> the condition. Stimulating the dorsal column of the spinal cord reduces
>> these oscillations, which researchers believe creates the ability to
>> produce
>> motor function.
>>
>> In a healthy body, neurons fire at varying rates as information is
>> transmitted between the brain and the body to initiate normal movement.
>> This
>> process breaks down in someone with Parkinson's disease.
>>
>> "Our device works as an interface with the brain to produce a neural
>> state
>> permissive for locomotion, facilitating immediate and dramatic recovery
>> of
>> movement," says Per Petersson, co-author of the study. "Following
>> stimulation, the neurons desynchronize, similar to the firing pattern
>> that
>> you would see when a healthy mouse is continuously moving."
>>
>> Nicolelis says that if the device is proven safe and effective through
>> further research, he imagines it mirroring similar spinal cord stimulator
>> technology currently used to treat chronic pain. Small leads are
>> implanted
>> over the spinal cord and then connected to a portable generator, a small
>> device capable of producing mild electrical currents. During the trial
>> period, the generator is external, while for permanent treatment it would
>> be
>> implanted below the skin.
>>
>> "If we can demonstrate that the device is safe and effective over the
>> long
>> term in primates and then humans, virtually every patient could be
>> eligible
>> for this treatment in the near future," Nicolelis said.
>>
>> The Duke team is collaborating with neuroscientists at the Edmond and
>> Lily
>> Safra International Institute of Neuroscience in Natal, Brazil, to test
>> the
>> new procedure in primate models of Parkinson's disease prior to
>> initiating
>> clinical studies. Neuroscientists from the Brain and Mind Institute at
>> the
>> Swiss Institute of Technology (EPFL), in Lausanne, Switzerland, will also
>> participate in this international research effort to translate these new
>> findings into clinical practice.
>> ###
>> Study co-authors include William Siesser and Marc Caron.
>>
>> Rayilyn Brown
>> Director AZNPF
>> Arizona Chapter National Parkinson Foundation
>> [log in to unmask]
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> ----------------------------------------------------------------------
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Week 4 June 1999, Week 3 June 1999, Week 2 June 1999, Week 1 May 1999, Week 5 May 1999, Week 4 May 1999, Week 3 May 1999, Week 2 May 1999, Week 1 April 1999, Week 5 April 1999, Week 4 April 1999, Week 3 April 1999, Week 2 April 1999, Week 1 March 1999, Week 5 March 1999, Week 4 March 1999, Week 3 March 1999, Week 2 March 1999, Week 1 February 1999, Week 4 February 1999, Week 3 February 1999, Week 2 February 1999, Week 1 January 1999, Week 5 January 1999, Week 4 January 1999, Week 3 January 1999, Week 2 January 1999, Week 1 December 1998, Week 5 December 1998, Week 4 December 1998, Week 3 December 1998, Week 2 December 1998, Week 1 November 1998, Week 5 November 1998, Week 4 November 1998, Week 3 November 1998, Week 2 November 1998, Week 1 October 1998, Week 5 October 1998, Week 4 October 1998, Week 3 October 1998, Week 2 October 1998, Week 1 September 1998, Week 5 September 1998, Week 4 September 1998, Week 3 September 1998, Week 2 September 1998, Week 1 August 1998, Week 5 August 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Week 4 October 1997, Week 3 October 1997, Week 2 October 1997, Week 1 September 1997, Week 5 September 1997, Week 4 September 1997, Week 3 September 1997, Week 2 September 1997, Week 1 August 1997, Week 5 August 1997, Week 4 August 1997, Week 3 August 1997, Week 2 August 1997, Week 1 July 1997, Week 5 July 1997, Week 4 July 1997, Week 3 July 1997, Week 2 July 1997, Week 1 June 1997, Week 5 June 1997, Week 4 June 1997, Week 3 June 1997, Week 2 June 1997, Week 1 May 1997, Week 5 May 1997, Week 4 May 1997, Week 3 May 1997, Week 2 May 1997, Week 1 April 1997, Week 5 April 1997, Week 4 April 1997, Week 3 April 1997, Week 2 April 1997, Week 1 March 1997, Week 5 March 1997, Week 4 March 1997, Week 3 March 1997, Week 2 March 1997, Week 1 February 1997, Week 5 February 1997, Week 4 February 1997, Week 3 February 1997, Week 2 February 1997, Week 1 January 1997, Week 5 January 1997, Week 4 January 1997, Week 3 January 1997, Week 2 January 1997, Week 1 December 1996, Week 5 December 1996, Week 4 December 1996, Week 3 December 1996, Week 2 December 1996, Week 1 November 1996, Week 5 November 1996, Week 4 November 1996, Week 3 November 1996, Week 2 November 1996, Week 1 October 1996, Week 5 October 1996, Week 4 October 1996, Week 3 October 1996, Week 2 October 1996, Week 1 September 1996, Week 5 September 1996, Week 4 September 1996, Week 3 September 1996, Week 2 September 1996, Week 1 August 1996, Week 5 August 1996, Week 4 August 1996, Week 3 August 1996, Week 2 August 1996, Week 1 July 1996, Week 5 July 1996, Week 4 July 1996, Week 3 July 1996, Week 2 July 1996, Week 1 June 1996, Week 5 June 1996, Week 4 June 1996, Week 3 June 1996, Week 2 June 1996, Week 1 May 1996, Week 5 May 1996, Week 4 May 1996, Week 3 May 1996, Week 2 May 1996, Week 1 April 1996, Week 5 April 1996, Week 4 April 1996, Week 3 April 1996, Week 2 April 1996, Week 1 March 1996, Week 5 March 1996, Week 4 March 1996, Week 3 March 1996, Week 2 March 1996, Week 1 February 1996, Week 5 February 1996, Week 4 February 1996, Week 3 February 1996, Week 2 February 1996, Week 1 January 1996, Week 5 January 1996, Week 4 January 1996, Week 3 January 1996, Week 2 January 1996, Week 1 December 1995, Week 5 December 1995, Week 4 December 1995, Week 3 December 1995, Week 2 December 1995, Week 1 November 1995, Week 5 November 1995, Week 4 November 1995, Week 3 November 1995, Week 2 November 1995, Week 1 October 1995, Week 5 October 1995, Week 4 October 1995, Week 3 October 1995, Week 2 October 1995, Week 1 September 1995, Week 5 September 1995, Week 4 September 1995, Week 3 September 1995, Week 2 September 1995, Week 1 August 1995, Week 5 August 1995, Week 4 August 1995, Week 3 August 1995, Week 2 August 1995, Week 1 July 1995, Week 5 July 1995, Week 4 July 1995, Week 3 July 1995, Week 2 July 1995, Week 1 June 1995, Week 5 June 1995, Week 4 June 1995, Week 3 June 1995, Week 2 June 1995, Week 1 May 1995, Week 5 May 1995, Week 4 May 1995, Week 3 May 1995, Week 2 May 1995, Week 1 April 1995, Week 5 April 1995, Week 4 April 1995, Week 3 April 1995, Week 2 April 1995, Week 1 March 1995, Week 5 March 1995, Week 4 March 1995, Week 3 March 1995, Week 2 March 1995, Week 1 February 1995, Week 4 February 1995, Week 3 February 1995, Week 2 February 1995, Week 1 January 1995, Week 5 January 1995, Week 4 January 1995, Week 3 January 1995, Week 2 January 1995, Week 1 December 1994, Week 5 December 1994, Week 4 December 1994, Week 3 December 1994, Week 2 December 1994, Week 1 November 1994, Week 5 November 1994, Week 4 November 1994, Week 3 November 1994, Week 2 November 1994, Week 1 October 1994, Week 5 October 1994, Week 4 October 1994, Week 3 October 1994, Week 2 October 1994, Week 1 September 1994, Week 5 September 1994, Week 4 September 1994, Week 3 September 1994, Week 2 September 1994, Week 1 August 1994, Week 5 August 1994, Week 4 August 1994, Week 3 August 1994, Week 2 August 1994, Week 1 July 1994, Week 5 July 1994, Week 4 July 1994, Week 3 July 1994, Week 2 July 1994, Week 1 June 1994, Week 5 June 1994, Week 4 June 1994, Week 3 June 1994, Week 2 June 1994, Week 1 May 1994, Week 5 May 1994, Week 4 May 1994, Week 3 May 1994, Week 2 May 1994, Week 1 April 1994, Week 5 April 1994, Week 4 April 1994, Week 3 April 1994, Week 2 April 1994, Week 1 March 1994, Week 5 March 1994, Week 4 March 1994, Week 3 March 1994, Week 2 March 1994, Week 1 February 1994, Week 4 February 1994, Week 3 February 1994, Week 2 February 1994, Week 1 February 1994 January 1994 December 1993 November 1993
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