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This sounds like very good news.
Kathleen
2009/3/27 rayilynlee <[log in to unmask]>
> Therapeutic Cloning Gets A Boost With New Research Findings
>
> ScienceDaily (Mar. 26, 2009) - Germ cells, the cells which give rise to a
> mammal's sperm or eggs, exhibit a five to ten-fold lower rate of spontaneous
> point mutations than adult somatic cells, which give rise to the body's
> remaining cell types, tissues and organs. Despite their comparatively higher
> mutation rates, however, adult somatic cells are used as the donor cells in
> a cloning process called somatic cell nuclear transfer (SCNT). This made
> researchers wonder if cloning by SCNT leads to progeny with more mutations
> than their naturally conceived counterparts. Also, would cloned fetuses
> receive DNA programming predisposing them to develop mutations faster than
> natural fetuses of the same age?
> Those scenarios are simply not likely, say researchers at The University of
> Texas at San Antonio, The University of Texas Health Science Center at San
> Antonio and The University of Hawaii at Honolulu's John A. Burns School of
> Medicine. The team, which spent more than five years analyzing mutation
> rates and types in cloned Big BlueŽ mouse fetuses recently published its
> findings in the online Early Edition of the Proceedings of the National
> Academy of Sciences in a paper titled "Epigenetic regulation of genetic
> integrity is reprogrammed during cloning."
>
> The paper offers the first direct demonstration that cloning does not lead
> to an increase in the frequency of point mutations.
>
> John McCarrey, professor of cellular and molecular biology at UTSA and the
> study's principal investigator, suggests a "bottleneck effect" is partially
> responsible for the observations his team recorded. "To create a cloned
> fetus by somatic cell nuclear transfer, only one adult somatic cell -- one
> donor cell -- is needed," he explains. "Because a random cell population
> exhibits a low mutation rate overall and only one cell from that population
> is used for cloning, the likelihood is remote that the cell chosen to be
> cloned will transfer a genetic mutation to its cloned offspring. Therefore,
> the bottleneck effect limits the transfer of mutations from donor cells to
> cloned offspring."
>
> Not only did the researchers find that SCNT does not lead to an increase in
> the frequency of point mutations in cloned mice, the team also found that
> naturally conceived fetuses and cloned fetuses that are the same age have
> similar rates of spontaneous mutation development. They attribute this
> finding to epigenetic reprogramming.
>
> It is known in the scientific community that germ cells contain an
> epigenome, a programmed state of the genome, that keeps mutation rates low.
> They suggest this type of epigenome is found in germ cells because those
> cells are responsible for contributing genetic information to subsequent
> generations. Adult somatic cells (the donor cells in SCNT) have higher
> mutation rates and less stringent epigenetic programming to avoid mutations
> than germ cells, but offspring produced from somatic cells by cloning have
> mutation rates similar to those in offspring produced by natural
> reproduction, suggesting that the epigenome of an adult somatic cell is
> reprogrammed during cloning to maintain the genetic integrity of that cell's
> progeny.
>
> Journal reference:
> Patricia Murphey, Yukiko Yamazaki, C. Alex McMahan, Christi A. Walter,
> Ryuzo Yanagimachi, and John R. McCarrey. Epigenetic regulation of genetic
> integrity is reprogrammed during cloning. Proceedings of the National
> Academy of Sciences, 2009; 106 (12): 4731 DOI: 10.1073/pnas.0900687106
> Adapted from materials provided by University of Texas at San Antonio, via
> EurekAlert!, a service of AAAS.
>
> Rayilyn Brown
> Director AZNPF
> Arizona Chapter National Parkinson Foundation
> [log in to unmask]
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December 1996, Week 3 December 1996, Week 2 December 1996, Week 1 November 1996, Week 5 November 1996, Week 4 November 1996, Week 3 November 1996, Week 2 November 1996, Week 1 October 1996, Week 5 October 1996, Week 4 October 1996, Week 3 October 1996, Week 2 October 1996, Week 1 September 1996, Week 5 September 1996, Week 4 September 1996, Week 3 September 1996, Week 2 September 1996, Week 1 August 1996, Week 5 August 1996, Week 4 August 1996, Week 3 August 1996, Week 2 August 1996, Week 1 July 1996, Week 5 July 1996, Week 4 July 1996, Week 3 July 1996, Week 2 July 1996, Week 1 June 1996, Week 5 June 1996, Week 4 June 1996, Week 3 June 1996, Week 2 June 1996, Week 1 May 1996, Week 5 May 1996, Week 4 May 1996, Week 3 May 1996, Week 2 May 1996, Week 1 April 1996, Week 5 April 1996, Week 4 April 1996, Week 3 April 1996, Week 2 April 1996, Week 1 March 1996, Week 5 March 1996, Week 4 March 1996, Week 3 March 1996, Week 2 March 1996, Week 1 February 1996, Week 5 February 1996, Week 4 February 1996, Week 3 February 1996, Week 2 February 1996, Week 1 January 1996, Week 5 January 1996, Week 4 January 1996, Week 3 January 1996, Week 2 January 1996, Week 1 December 1995, Week 5 December 1995, Week 4 December 1995, Week 3 December 1995, Week 2 December 1995, Week 1 November 1995, Week 5 November 1995, Week 4 November 1995, Week 3 November 1995, Week 2 November 1995, Week 1 October 1995, Week 5 October 1995, Week 4 October 1995, Week 3 October 1995, Week 2 October 1995, Week 1 September 1995, Week 5 September 1995, Week 4 September 1995, Week 3 September 1995, Week 2 September 1995, Week 1 August 1995, Week 5 August 1995, Week 4 August 1995, Week 3 August 1995, Week 2 August 1995, Week 1 July 1995, Week 5 July 1995, Week 4 July 1995, Week 3 July 1995, Week 2 July 1995, Week 1 June 1995, Week 5 June 1995, Week 4 June 1995, Week 3 June 1995, Week 2 June 1995, Week 1 May 1995, Week 5 May 1995, Week 4 May 1995, Week 3 May 1995, Week 2 May 1995, Week 1 April 1995, Week 5 April 1995, Week 4 April 1995, Week 3 April 1995, Week 2 April 1995, Week 1 March 1995, Week 5 March 1995, Week 4 March 1995, Week 3 March 1995, Week 2 March 1995, Week 1 February 1995, Week 4 February 1995, Week 3 February 1995, Week 2 February 1995, Week 1 January 1995, Week 5 January 1995, Week 4 January 1995, Week 3 January 1995, Week 2 January 1995, Week 1 December 1994, Week 5 December 1994, Week 4 December 1994, Week 3 December 1994, Week 2 December 1994, Week 1 November 1994, Week 5 November 1994, Week 4 November 1994, Week 3 November 1994, Week 2 November 1994, Week 1 October 1994, Week 5 October 1994, Week 4 October 1994, Week 3 October 1994, Week 2 October 1994, Week 1 September 1994, Week 5 September 1994, Week 4 September 1994, Week 3 September 1994, Week 2 September 1994, Week 1 August 1994, Week 5 August 1994, Week 4 August 1994, Week 3 August 1994, Week 2 August 1994, Week 1 July 1994, Week 5 July 1994, Week 4 July 1994, Week 3 July 1994, Week 2 July 1994, Week 1 June 1994, Week 5 June 1994, Week 4 June 1994, Week 3 June 1994, Week 2 June 1994, Week 1 May 1994, Week 5 May 1994, Week 4 May 1994, Week 3 May 1994, Week 2 May 1994, Week 1 April 1994, Week 5 April 1994, Week 4 April 1994, Week 3 April 1994, Week 2 April 1994, Week 1 March 1994, Week 5 March 1994, Week 4 March 1994, Week 3 March 1994, Week 2 March 1994, Week 1 February 1994, Week 4 February 1994, Week 3 February 1994, Week 2 February 1994, Week 1 February 1994 January 1994 December 1993 November 1993
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