Your reference sounds like a good one. I'll need to check it out. I have
mainly just used the NIH library and other doctor source  informations.
Rob

----- Original Message -----
From: <[log in to unmask]>
To: <[log in to unmask]>
Sent: Sunday, May 10, 2009 9:23 AM
Subject: Re: Question re milk thistleand tyrosine


>
>
> The following taken from "Prescription for Nutritional Healing" Third
> Edition:
>
> "Tyrosine is important to overall metabolism.  It is a precursor  of
> adrenaline and the neurotransmiters norepinephrine and dopamine, which
regulate
> mood and stimulate metabolism and the nervous system.   Tyrosine acts as a
> mood elevator; a lack of adequate amounts of tyrosine  leads to a
deficiency
> of norepinephrine in the brain, which in turn can  result in depression.
It
> also acts as a mild antioxidant, suppresses  the appetite, and helps to
> reduce body fat.  It aids in the  production of melanin (the pigment
responsible
> for skin and hair color)  and in the functions of the adrenal, thyroid,
and
> pituitary glands.   It is also involved in the metabolism of the amino
acid
>  phenylalanine.
>
> Tyrosine attaches to iodine atoms to form active thyroid  hormones.  Not
> surprisingly, therefore, low plasma levels of tyrosine  have been
associated
> with hypothyroidism.  Symptoms of tyrosine  deficiency can also include
low
> blood pressure, low body temperature (such  as cold hands and feet), and
> restless leg syndrome.
>
> Supplemental L-tyrosine has been used for stress reduction, and  research
> suggests it may be helpful against chronic fatigue and  narcolepsy.  It
has
> been used to help individuals suffering from  anxiety, depression, low sex
> drive, allergies, and headaches, as well as  persons undergoing withdrawal
> from drugs.  It may also help people  with Parkinson's disease.
>
> Natural resources of tyrosine include almonds, avocados, bananas,  dairy
> products, lima beans, pumpkin seeds, and sesame seeds.   Tyrosine can also
be
> produced from phenylalanine in the body.   Supplements of L-tyrosine
should
> be taken at bedtime or with a  high-carbohydrate meal so that it does not
> have to complete for absorption  with other amino acids.
>
> Persons taking monoamine oxidase (MAO)) inhibitors, commonly  prescribed
> for depression, must strictly limit their intake of foods  containing
tyrosine
> and should not take any supplements  containing L-tyrosine, as it may lead
> to a sudden and dangerous rise in  blood pressure.  Anyone who takes
> prescription medication for  depression should discuss necessary dietary
> restrictions with his or her  physician."
>
> I take Azilect which is an MOA (B) not (A) inhibitor so I don't know  if
> the last paragraph would apply as I obviously don't take it for
depression
> but for PD.  I guess I'll need to research further unless  anyone on this
> forum knows the answer.
>
> Roberta Innarella
>
>
> In a message dated 5/10/2009 3:27:33 A.M. Eastern Daylight Time,
> [log in to unmask] writes:
>
> Schaff:
>
> I ordered 1000 msg milk thistle and 500 msg  L-tyrosine - is that the
> correct
> amount or not?
> thanks so much  and for clarifying the bp issue.  I  couldn't find
anything
>
> on line that said tyrosine caused high bp - and yes it did claim  these 2
> supplements as treatment for PD.  thanks so very  much
>
> here's hoping....I don't take PD meds you know, but am  getting worse
>
> Ray
>
> Rayilyn Brown
> Director  AZNPF
> Arizona Chapter National Parkinson  Foundation
> [log in to unmask]
>
> --------------------------------------------------
> From:  "Schaaf Angus / Meadow Creek Ranch" <[log in to unmask]>
> Sent:  Sunday, May 10, 2009 8:09 PM
> To:  <[log in to unmask]>
> Subject: Re: Question re milk  thistleand tyrosine
>
> > To the best of my knowledge tyrosine has  no impact on blood pressure.
It
> > is
> > a precursor  necessary for the production of dopamine by the liver. It
is
> >  quite beneficial. Salt and sugar as well as poor diets have more impact
> on
> > BP .
> > Hope this helps.
> > If it werent for  tyrosine in my program I couldnt do the 5 to 6 hours
of
> > walking  I've been doing the last few days fixing storm damage on the
> ranch
> > fences. Needless to say by sundown I'm really wornout for  the day.
> > Have a good Sunday Ray.
> >
> > ----- Original  Message -----
> > From: "rayilynlee"  <[log in to unmask]>
> > To:  <[log in to unmask]>
> > Sent: Friday, May 08, 2009  10:48 AM
> > Subject: Re: Question re milk  thistle
> >
> >
> >> thanks Roberta  - I take bp  medication
> >> Ray
> >>
> >> Rayilyn  Brown
> >> Director AZNPF
> >> Arizona Chapter National  Parkinson Foundation
> >>  [log in to unmask]
> >>
> >>  --------------------------------------------------
> >> From:  <[log in to unmask]>
> >> Sent: Thursday, May 07, 2009 4:03  AM
> >> To: <[log in to unmask]>
> >>  Subject: Re: Question re milk thistle
> >>
> >>  >
> >> >
> >> > Doesn't Tyrosine increase blood  pressure?
> >> >
> >> > Roberta  Innarella
> >> >
> >> >
> >> > In a  message dated 5/7/2009 2:01:57 A.M. Eastern Daylight Time,
> >>  > [log in to unmask] writes:
> >> >
> >> >  Yep!
> >> >
> >> > ----- Original Message  -----
> >> > From:  "rayilynlee"  <[log in to unmask]>
> >> > To:   <[log in to unmask]>
> >> > Sent: Tuesday,  May 05, 2009  9:45 AM
> >> > Subject: Re: Question re  milk thistle
> >> >
> >> >
> >> >> gee,  I  didn't know milk thistle would help my liver produce
> dopamine.
> >> >> I
> >> >> started taking it  for constipation.  Do I need to take  tyrosine
with
> >  it?
> >> >>
> >> >> Ray
> >>  >>
> >> >> Rayilyn  Brown
> >> >>  Director AZNPF
> >> >> Arizona Chapter National  Parkinson  Foundation
> >> >>  [log in to unmask]
> >> >>
> >> >>   --------------------------------------------------
> >> >>  From: "Schaaf  Angus / Meadow Creek Ranch"  <[log in to unmask]>
> >> >> Sent:  Tuesday, May  05, 2009 8:40 AM
> >> >> To:   <[log in to unmask]>
> >> >> Subject:  Question re  Amantadine/  GSH importance
> >>  >>
> >> >> > Couple of  thoughts.
> >>  >> > Have you tried to let your liver produce your   dopamine needs by
> > taking
> >> >> > tyrosine and  milk thistle?
> >> >>  > The natural production of  GSH  by the body is a little more
> >> >  complicated
> >> >> > but
> >> >> >  following is article from my  archives that helps  explain.
> >> >> >      WHY   GSH
> >> >> > Oxidative stress appears to play an  important role in
degeneration
> > of
> >> >>  > dopaminergic neurons of the substantia  nigra (SN) associated
with
> >> >> > Parkinson's disease (PD). The SN  of  early PD patients have
> >> >> >  dramatically
> >> >> > decreased levels of  the  thiol tripeptide glutathione (GSH). GSH
> > plays
> >>  >> > multiple  roles in the nervous system both as an  antioxidant and
a
> >> >> > redox
> >>  >>  > modulator. We have generated dopaminergic PC12 cell  lines in
> which
> >> > levels
> >> >> >  of
> >> >> > GSH can be inducibly  down-regulated  via doxycycline induction of
> >> > antisense
> >>  >> >  messages against both the heavy and light subunits  of
> >> >> >  gamma-glutamyl-cysteine synthetase,  the rate-limiting enzyme in
> >> >>  >  glutathione
> >> >> > synthesis. Down-regulation  of  glutamyl-cysteine synthetase
results
> > in
> >>  >> > reduction in  mitochondrial GSH levels, increased  oxidative
> stress,
> > and
> >> >> >  decreased  mitochondrial function. Interestingly, decreases in
> >>  >>  > mitochondrial
> >> >> > activities  in GSH-depleted PC12 cells  appears to be because of a
> >>  > selective
> >> >> > inhibition of  complex I  activity as a result of thiol oxidation.
> > These
> >>  >> >  results suggest that the early observed GSH losses  in the SN
may
> >> >> > be
> >> >> >  directly
> >> >> > responsible for the noted   decreases in complex I activity and
the
> >> >> >  subsequent
> >> >>  > mitochondrial dysfunction,  which ultimately leads to
dopaminergic
> >> >>  cell
> >> >> > death
> >> >> >  associated with PD.
> >> >>  >
> >> >>  >   WHY GLUTAMINE
> >> >> > Glutamine is  an  important mitochondrial substrate implicated in
> the
> >>  >> >  protection of cells from oxidant injury. Human  pulmonary
> >> > epithelial-like
> >> >> >  (A549) cells were exposed to 95% O(2) for 4  days in the absence
> and
> >> >> > presence
> >> >> > of  glutamine.  Cell proliferation in normoxia was dependent  on
> >> > glutamine,
> >> >> >   and
> >> >> > glutamine deprivation markedly accelerated  cell death  in
> hyperoxia.
> >> >> > Glutamine  significantly increased cellular  ATP levels in
normoxia
> >  and
> >> >> > prevented the loss of ATP in   hyperoxia seen in
glutamine-deprived
> >> > cells.
> >>  >> > Mitochondrial  membrane potential as assessed by flow  cytometry
> with
> >> >> >   chloromethyltetramethylrosamine was increased by glutamine  in
> >> >>  > hyperoxia-exposed A549 cells, and a  glutamine dose-dependent
> > increase
> >> >  in
> >> >> > mitochondrial membrane potential was  detected.
> > Glutamine-supplemented,
> >> >> >  hyperoxia-exposed cells had a  HIGHER  O(2) consumption rate  and
> GSH
> >> >> > content.
> >> >>   > Electron and fluorescence microscopy revealed that, in
> hyperoxia,
> >> >> > glutamine
> >> >> >  protected cellular  structures, especially mitochondria, from
> >> >> > damage.
> >> >> >  In
> >> >> >  hyperoxia, activity of the  tricarboxylic acid cycle enzyme
> >> >> >   alpha-ketoglutarate dehydrogenase was partially protected by
its
> >> > indirect
> >> >> > substrate,  glutamine, indicating a  mechanism of mitochondrial
> >>  > protection.
> >> >> > THEREFORE:   I take  L-Glutamine and DHEA to increase the level of
> >> >> >  GSH
> >> >> > in
> >> >> >   the
> >> >> > body naturally to further thwart the  symptoms and  destruction of
> > P.D.
> >> >> >  along
> >> >> > with my other  vitamin/mineral  protocol which exclude PD drugs.
As
> a
> >> > note.
> >>  >>  > I
> >> >> > never tried the  Amantadine. My doctors forced me  early to look
> >> >  elsewhere
> >> >> > for
> >> >> > help  since they  couldnt due to lack of knowledge or incentive.
> Not
> >> >> > sure
> >> >> >  which  but I'm alot healthier for switching to a no drug
> protocol.
> >> >> >
> >> >> > -----  Original Message -----
> >> >>  > From: "Ernesto  Divo" <[log in to unmask]>
> >> >> > To:   <[log in to unmask]>
> >> >> > Sent:  Sunday, May 03,  2009 12:24 PM
> >> >> > Subject:  Re: Question re Amantadine  use
> >> >>  >
> >> >> >
> >> >> >> Hi  John,
> >> >>  >>
> >> >> >>  I'm 56 and was diagnosed with PD in 2000, I've  been taking
> Azilect
> >> >> >> and
> >> >> >>  Requip (Ropinirole) the nausea  form the Requip is  unbearable.
I
> > have
> >> >> >>  introduced  to my regimen for the past 5 months or so, 'MaxGXL',
> a
> >> >> >  supplement
> >> >>  >> developed here in the US, by a US scientist  and sold by a  US
> >> >> >> company. It raises thet levels of  GSH  in your cells naturally.
It
> >> >> >>  took
> >> >> >> the
> >> >>  >>  GXL about a week to work on my sleeping pattern, I was  waking
up
> > 2-3
> >> >> >> times
> >>  >> >> during the night, now I  sleep straight thru the  night, and it
> took
> >> > about
> >> >>  >>  three weeks to work on my cognitive process but it was so
> subtle
> >> >> >> I
> >> >  barely
> >> >> >> thought it was the GXL. I wasn't  having  problems looking for
> words
> > to
> >> >>  > finish
> >> >> >> a  sentence, my memory is  back, I don't lose things around the
> > house,
> >> >  I
> >> >> > have
> >> >> >> more  energy and I feel good and my  wife is happier.  It is
> >> >> >> strange,
> >> >  when
> >> >> >> I
> >> >>  >>  asked my doctor about it he said Gluta what?  it seems the
> >> >> medical
> >> >> >  community
> >> >> >> is keeping the use of   Glutathione (GSH) under wraps, they don't
> > want
> >>  >> >>  competition...  I order mine from  www.maxgxl.com/133282  I
> >> >> >>  suggest
> >> >> >> getting
> >> >>  >> as much info as  possible of GSH, I went to  www.youtube.com and
> >> > searched
> >> >>  >  for
> >> >> >> 'The mother of all  antioxidants', there is this  doctor Mark
Hyman
> >  who
> >> >> >> explains in details about GSH;   excellent video.
> >> >> >>
> >> >>  >> Good luck to  you.
> >> >>  >>
> >> >> >> Ernesto,
> >> >>  >> Miami,  FL
> >> >> >>
> >>  >> >> On Sat, May 2, 2009 at 11:46 AM,  john  emrys
> > <[log in to unmask]>
> >> >> >  wrote:
> >> >>  >>
> >> >> >>  > Hey John
> >> >> >> >
> >>  >>  >> > I've been on Amantadine since being  diagnosed in October  of
> >> >> last
> >>  > year;
> >> >> >> > dosage has remained  constant and  titrated from 100mg to 300mg
> >> >>  >> > per
> >> > day,
> >> >> >  over
> >> >>  >> > an initial period of 3  weeks.
> >> >> >>  >
> >> >>  >> > I space the dosing about 5-ish hours apart;  I've  found if
the
> > final
> >> >> >> >  dose
> >> >> >  of
> >> >> >>  > 100mg is taken later than 8PM, I have trouble  sleeping
through
> > the
> >> >> > night.
> >>  >> >> >
> >> >>  >> > It does  give me an energy boost and some minor relief from
> >  muscle
> >> >> >> > tightness, but does nothing to  improve gait  or reduce tremor.
> > It's
> >> >  sort
> >> >> > of
> >> >> >>  >  just a little bit of "gas" for your "engine."
> >>  >> >>  >
> >> >> >> > On the  other hand, I find it causes auditory  hallucinations,
> >>  >> >> > drowsiness,
> >> >> >>  >  occasional vertigo, foggy thought processing and swelling
> around
> >> > the
> >> >> > knees.
> >>  >> >> >
> >> >> >> > I  find  much better results on GSH and mucuna bean, which I
> >  started
> >> >>  >> > about
> >>  >> > 6
> >> >> >> > months ago (the   mucuna has been a very recent thing, so it's
> >> >>  >> > been
> >> > too
> >> >> >   early
> >> >> >> > to tell – but so far, I'm  definitely  impressed). My neuro
> >> >  practically
> >> >> > lit
> >> >> >>  >  his own hair on fire when I told him, but he couldn't  deny
> the
> >> > results
> >> >> >  of
> >> >> >> > the GSH.
> >>  >>  >> >
> >> >> >> > The goal  is to be able to cut the  amantadine by 35 - 50%
> within
> >> >> >> > 6
> >> >> >  months.
> >> >> >>  > My view is the longer I  stay away from starting the agonists,
> > the
> >> >>  > better.
> >> >> >> >
> >> >>  >> >  Hope that helps.
> >> >> >>  >
> >> >> >> >
> >> >>   >> >
> >> >> >> > Joh
> >>  >> >> >
> >> >>  >>  >
> >> >> >>
> >>
> >>  >>  >
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> >>  >>
> >> >> >>
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