Does anyone have experience with Resveratrol? It  is said to protect brain agaist free radical attack and beta amyloid neurotoxicity and to stop cancerous development at any stage. 


Ansa Ojanlatva, PhD, CHES (ret.)
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----- Original Message -----
From: rayilynlee <[log in to unmask]>
Date: Wednesday, May 13, 2009 9:05 am
Subject: Re: Question re milk thistleand tyrosine
To: [log in to unmask]


> Roberta
> 
> I don't take any MAO inhibitors or much else so the tyrosine is most 
> likely 
> OK for me.  thanks for clarifying the issue.  It would be great if I 
> could 
> lose some fat.
> Ray
> Rayilyn Brown
> Director AZNPF
> Arizona Chapter National Parkinson Foundation
> [log in to unmask]
> 
> --------------------------------------------------
> From: <[log in to unmask]>
> Sent: Sunday, May 10, 2009 8:23 AM
> To: <[log in to unmask]>
> Subject: Re: Question re milk thistleand tyrosine
> 
> >
> >
> > The following taken from "Prescription for Nutritional Healing" Third
> > Edition:
> >
> > "Tyrosine is important to overall metabolism.  It is a precursor  of
> > adrenaline and the neurotransmiters norepinephrine and dopamine, 
> which 
> > regulate
> > mood and stimulate metabolism and the nervous system.   Tyrosine 
> acts as a
> > mood elevator; a lack of adequate amounts of tyrosine  leads to a 
> > deficiency
> > of norepinephrine in the brain, which in turn can  result in 
> depression. 
> > It
> > also acts as a mild antioxidant, suppresses  the appetite, and helps 
> to
> > reduce body fat.  It aids in the  production of melanin (the pigment 
> 
> > responsible
> > for skin and hair color)  and in the functions of the adrenal, 
> thyroid, 
> > and
> > pituitary glands.   It is also involved in the metabolism of the 
> amino 
> > acid
> > phenylalanine.
> >
> > Tyrosine attaches to iodine atoms to form active thyroid  hormones.  
> Not
> > surprisingly, therefore, low plasma levels of tyrosine  have been 
> > associated
> > with hypothyroidism.  Symptoms of tyrosine  deficiency can also 
> include 
> > low
> > blood pressure, low body temperature (such  as cold hands and feet), 
> and
> > restless leg syndrome.
> >
> > Supplemental L-tyrosine has been used for stress reduction, and  research
> > suggests it may be helpful against chronic fatigue and  narcolepsy.  
> It 
> > has
> > been used to help individuals suffering from  anxiety, depression, 
> low sex
> > drive, allergies, and headaches, as well as  persons undergoing withdrawal
> > from drugs.  It may also help people  with Parkinson's disease.
> >
> > Natural resources of tyrosine include almonds, avocados, bananas,  dairy
> > products, lima beans, pumpkin seeds, and sesame seeds.   Tyrosine 
> can also 
> > be
> > produced from phenylalanine in the body.   Supplements of L-tyrosine 
> 
> > should
> > be taken at bedtime or with a  high-carbohydrate meal so that it 
> does not
> > have to complete for absorption  with other amino acids.
> >
> > Persons taking monoamine oxidase (MAO)) inhibitors, commonly  prescribed
> > for depression, must strictly limit their intake of foods  
> containing 
> > tyrosine
> > and should not take any supplements  containing L-tyrosine, as it 
> may lead
> > to a sudden and dangerous rise in  blood pressure.  Anyone who takes
> > prescription medication for  depression should discuss necessary dietary
> > restrictions with his or her  physician."
> >
> > I take Azilect which is an MOA (B) not (A) inhibitor so I don't know 
>  if
> > the last paragraph would apply as I obviously don't take it for 
> > depression
> > but for PD.  I guess I'll need to research further unless  anyone on 
> this
> > forum knows the answer.
> >
> > Roberta Innarella
> >
> >
> > In a message dated 5/10/2009 3:27:33 A.M. Eastern Daylight Time,
> > [log in to unmask] writes:
> >
> > Schaff:
> >
> > I ordered 1000 msg milk thistle and 500 msg  L-tyrosine - is that the
> > correct
> > amount or not?
> > thanks so much  and for clarifying the bp issue.  I  couldn't find 
> > anything
> >
> > on line that said tyrosine caused high bp - and yes it did claim  
> these 2
> > supplements as treatment for PD.  thanks so very  much
> >
> > here's hoping....I don't take PD meds you know, but am  getting worse
> >
> > Ray
> >
> > Rayilyn Brown
> > Director  AZNPF
> > Arizona Chapter National Parkinson  Foundation
> > [log in to unmask]
> >
> > --------------------------------------------------
> > From:  "Schaaf Angus / Meadow Creek Ranch" <[log in to unmask]>
> > Sent:  Sunday, May 10, 2009 8:09 PM
> > To:  <[log in to unmask]>
> > Subject: Re: Question re milk  thistleand tyrosine
> >
> >> To the best of my knowledge tyrosine has  no impact on blood 
> pressure. It
> >> is
> >> a precursor  necessary for the production of dopamine by the liver. 
> It is
> >>  quite beneficial. Salt and sugar as well as poor diets have more impact
> > on
> >> BP .
> >> Hope this helps.
> >> If it werent for  tyrosine in my program I couldnt do the 5 to 6 
> hours of
> >> walking  I've been doing the last few days fixing storm damage on the
> > ranch
> >> fences. Needless to say by sundown I'm really wornout for  the day.
> >> Have a good Sunday Ray.
> >>
> >> ----- Original  Message -----
> >> From: "rayilynlee"  <[log in to unmask]>
> >> To:  <[log in to unmask]>
> >> Sent: Friday, May 08, 2009  10:48 AM
> >> Subject: Re: Question re milk  thistle
> >>
> >>
> >>> thanks Roberta  - I take bp  medication
> >>> Ray
> >>>
> >>> Rayilyn  Brown
> >>> Director AZNPF
> >>> Arizona Chapter National  Parkinson Foundation
> >>>  [log in to unmask]
> >>>
> >>>  --------------------------------------------------
> >>> From:  <[log in to unmask]>
> >>> Sent: Thursday, May 07, 2009 4:03  AM
> >>> To: <[log in to unmask]>
> >>>  Subject: Re: Question re milk thistle
> >>>
> >>>  >
> >>> >
> >>> > Doesn't Tyrosine increase blood  pressure?
> >>> >
> >>> > Roberta  Innarella
> >>> >
> >>> >
> >>> > In a  message dated 5/7/2009 2:01:57 A.M. Eastern Daylight Time,
> >>>  > [log in to unmask] writes:
> >>> >
> >>> >  Yep!
> >>> >
> >>> > ----- Original Message  -----
> >>> > From:  "rayilynlee"  <[log in to unmask]>
> >>> > To:   <[log in to unmask]>
> >>> > Sent: Tuesday,  May 05, 2009  9:45 AM
> >>> > Subject: Re: Question re  milk thistle
> >>> >
> >>> >
> >>> >> gee,  I  didn't know milk thistle would help my liver produce
> > dopamine.
> >>> >> I
> >>> >> started taking it  for constipation.  Do I need to take  
> tyrosine 
> >>> >> with
> >>  it?
> >>> >>
> >>> >> Ray
> >>>  >>
> >>> >> Rayilyn  Brown
> >>> >>  Director AZNPF
> >>> >> Arizona Chapter National  Parkinson  Foundation
> >>> >>  [log in to unmask]
> >>> >>
> >>> >>   --------------------------------------------------
> >>> >>  From: "Schaaf  Angus / Meadow Creek Ranch"  <[log in to unmask]>
> >>> >> Sent:  Tuesday, May  05, 2009 8:40 AM
> >>> >> To:   <[log in to unmask]>
> >>> >> Subject:  Question re  Amantadine/  GSH importance
> >>>  >>
> >>> >> > Couple of  thoughts.
> >>>  >> > Have you tried to let your liver produce your   dopamine 
> needs by
> >> taking
> >>> >> > tyrosine and  milk thistle?
> >>> >>  > The natural production of  GSH  by the body is a little more
> >>> >  complicated
> >>> >> > but
> >>> >> >  following is article from my  archives that helps  explain.
> >>> >> >      WHY   GSH
> >>> >> > Oxidative stress appears to play an  important role in 
> >>> >> > degeneration
> >> of
> >>> >>  > dopaminergic neurons of the substantia  nigra (SN) 
> associated 
> >>> >> with
> >>> >> > Parkinson's disease (PD). The SN  of  early PD patients have
> >>> >> >  dramatically
> >>> >> > decreased levels of  the  thiol tripeptide glutathione (GSH). 
> GSH
> >> plays
> >>>  >> > multiple  roles in the nervous system both as an  
> antioxidant and 
> >>> a
> >>> >> > redox
> >>>  >>  > modulator. We have generated dopaminergic PC12 cell  lines 
> in
> > which
> >>> > levels
> >>> >> >  of
> >>> >> > GSH can be inducibly  down-regulated  via doxycycline 
> induction of
> >>> > antisense
> >>>  >> >  messages against both the heavy and light subunits  of
> >>> >> >  gamma-glutamyl-cysteine synthetase,  the rate-limiting 
> enzyme in
> >>> >>  >  glutathione
> >>> >> > synthesis. Down-regulation  of  glutamyl-cysteine synthetase 
> 
> >>> >> > results
> >> in
> >>>  >> > reduction in  mitochondrial GSH levels, increased  oxidative
> > stress,
> >> and
> >>> >> >  decreased  mitochondrial function. Interestingly, decreases 
> in
> >>>  >>  > mitochondrial
> >>> >> > activities  in GSH-depleted PC12 cells  appears to be because 
> of a
> >>>  > selective
> >>> >> > inhibition of  complex I  activity as a result of thiol oxidation.
> >> These
> >>>  >> >  results suggest that the early observed GSH losses  in the 
> SN may
> >>> >> > be
> >>> >> >  directly
> >>> >> > responsible for the noted   decreases in complex I activity 
> and the
> >>> >> >  subsequent
> >>> >>  > mitochondrial dysfunction,  which ultimately leads to dopaminergic
> >>> >>  cell
> >>> >> > death
> >>> >> >  associated with PD.
> >>> >>  >
> >>> >>  >   WHY GLUTAMINE
> >>> >> > Glutamine is  an  important mitochondrial substrate 
> implicated in
> > the
> >>>  >> >  protection of cells from oxidant injury. Human  pulmonary
> >>> > epithelial-like
> >>> >> >  (A549) cells were exposed to 95% O(2) for 4  days in the absence
> > and
> >>> >> > presence
> >>> >> > of  glutamine.  Cell proliferation in normoxia was dependent  
> on
> >>> > glutamine,
> >>> >> >   and
> >>> >> > glutamine deprivation markedly accelerated  cell death  in
> > hyperoxia.
> >>> >> > Glutamine  significantly increased cellular  ATP levels in normoxia
> >>  and
> >>> >> > prevented the loss of ATP in   hyperoxia seen in glutamine-deprived
> >>> > cells.
> >>>  >> > Mitochondrial  membrane potential as assessed by flow  cytometry
> > with
> >>> >> >   chloromethyltetramethylrosamine was increased by glutamine  
> in
> >>> >>  > hyperoxia-exposed A549 cells, and a  glutamine dose-dependent
> >> increase
> >>> >  in
> >>> >> > mitochondrial membrane potential was  detected.
> >> Glutamine-supplemented,
> >>> >> >  hyperoxia-exposed cells had a  HIGHER  O(2) consumption rate 
>  and
> > GSH
> >>> >> > content.
> >>> >>   > Electron and fluorescence microscopy revealed that, in
> > hyperoxia,
> >>> >> > glutamine
> >>> >> >  protected cellular  structures, especially mitochondria, from
> >>> >> > damage.
> >>> >> >  In
> >>> >> >  hyperoxia, activity of the  tricarboxylic acid cycle enzyme
> >>> >> >   alpha-ketoglutarate dehydrogenase was partially protected 
> by 
> >>> >> > its
> >>> > indirect
> >>> >> > substrate,  glutamine, indicating a  mechanism of mitochondrial
> >>>  > protection.
> >>> >> > THEREFORE:   I take  L-Glutamine and DHEA to increase the 
> level of
> >>> >> >  GSH
> >>> >> > in
> >>> >> >   the
> >>> >> > body naturally to further thwart the  symptoms and  
> destruction of
> >> P.D.
> >>> >> >  along
> >>> >> > with my other  vitamin/mineral  protocol which exclude PD 
> drugs. As
> > a
> >>> > note.
> >>>  >>  > I
> >>> >> > never tried the  Amantadine. My doctors forced me  early to look
> >>> >  elsewhere
> >>> >> > for
> >>> >> > help  since they  couldnt due to lack of knowledge or incentive.
> > Not
> >>> >> > sure
> >>> >> >  which  but I'm alot healthier for switching to a no drug
> > protocol.
> >>> >> >
> >>> >> > -----  Original Message -----
> >>> >>  > From: "Ernesto  Divo" <[log in to unmask]>
> >>> >> > To:   <[log in to unmask]>
> >>> >> > Sent:  Sunday, May 03,  2009 12:24 PM
> >>> >> > Subject:  Re: Question re Amantadine  use
> >>> >>  >
> >>> >> >
> >>> >> >> Hi  John,
> >>> >>  >>
> >>> >> >>  I'm 56 and was diagnosed with PD in 2000, I've  been taking
> > Azilect
> >>> >> >> and
> >>> >> >>  Requip (Ropinirole) the nausea  form the Requip is  
> unbearable. 
> >>> >> >> I
> >> have
> >>> >> >>  introduced  to my regimen for the past 5 months or so, 'MaxGXL',
> > a
> >>> >> >  supplement
> >>> >>  >> developed here in the US, by a US scientist  and sold by a  
> US
> >>> >> >> company. It raises thet levels of  GSH  in your cells 
> naturally. 
> >>> >> >> It
> >>> >> >>  took
> >>> >> >> the
> >>> >>  >>  GXL about a week to work on my sleeping pattern, I was  
> waking 
> >>> >> up
> >> 2-3
> >>> >> >> times
> >>>  >> >> during the night, now I  sleep straight thru the  night, 
> and it
> > took
> >>> > about
> >>> >>  >>  three weeks to work on my cognitive process but it was so
> > subtle
> >>> >> >> I
> >>> >  barely
> >>> >> >> thought it was the GXL. I wasn't  having  problems looking for
> > words
> >> to
> >>> >>  > finish
> >>> >> >> a  sentence, my memory is  back, I don't lose things around 
> the
> >> house,
> >>> >  I
> >>> >> > have
> >>> >> >> more  energy and I feel good and my  wife is happier.  It is
> >>> >> >> strange,
> >>> >  when
> >>> >> >> I
> >>> >>  >>  asked my doctor about it he said Gluta what?  it seems the
> >>> >> medical
> >>> >> >  community
> >>> >> >> is keeping the use of   Glutathione (GSH) under wraps, they 
> don't
> >> want
> >>>  >> >>  competition...  I order mine from  www.maxgxl.com/133282  
> I
> >>> >> >>  suggest
> >>> >> >> getting
> >>> >>  >> as much info as  possible of GSH, I went to  
> www.youtube.com and
> >>> > searched
> >>> >>  >  for
> >>> >> >> 'The mother of all  antioxidants', there is this  doctor 
> Mark 
> >>> >> >> Hyman
> >>  who
> >>> >> >> explains in details about GSH;   excellent video.
> >>> >> >>
> >>> >>  >> Good luck to  you.
> >>> >>  >>
> >>> >> >> Ernesto,
> >>> >>  >> Miami,  FL
> >>> >> >>
> >>>  >> >> On Sat, May 2, 2009 at 11:46 AM,  john  emrys
> >> <[log in to unmask]>
> >>> >> >  wrote:
> >>> >>  >>
> >>> >> >>  > Hey John
> >>> >> >> >
> >>>  >>  >> > I've been on Amantadine since being  diagnosed in 
> October  of
> >>> >> last
> >>>  > year;
> >>> >> >> > dosage has remained  constant and  titrated from 100mg to 
> 300mg
> >>> >>  >> > per
> >>> > day,
> >>> >> >  over
> >>> >>  >> > an initial period of 3  weeks.
> >>> >> >>  >
> >>> >>  >> > I space the dosing about 5-ish hours apart;  I've  found 
> if the
> >> final
> >>> >> >> >  dose
> >>> >> >  of
> >>> >> >>  > 100mg is taken later than 8PM, I have trouble  sleeping 
> >>> >> >> through
> >> the
> >>> >> > night.
> >>>  >> >> >
> >>> >>  >> > It does  give me an energy boost and some minor relief from
> >>  muscle
> >>> >> >> > tightness, but does nothing to  improve gait  or reduce tremor.
> >> It's
> >>> >  sort
> >>> >> > of
> >>> >> >>  >  just a little bit of "gas" for your "engine."
> >>>  >> >>  >
> >>> >> >> > On the  other hand, I find it causes auditory  hallucinations,
> >>>  >> >> > drowsiness,
> >>> >> >>  >  occasional vertigo, foggy thought processing and swelling
> > around
> >>> > the
> >>> >> > knees.
> >>>  >> >> >
> >>> >> >> > I  find  much better results on GSH and mucuna bean, which 
> I
> >>  started
> >>> >>  >> > about
> >>>  >> > 6
> >>> >> >> > months ago (the   mucuna has been a very recent thing, so 
> it's
> >>> >>  >> > been
> >>> > too
> >>> >> >   early
> >>> >> >> > to tell – but so far, I'm  definitely  impressed). My neuro
> >>> >  practically
> >>> >> > lit
> >>> >> >>  >  his own hair on fire when I told him, but he couldn't  deny
> > the
> >>> > results
> >>> >> >  of
> >>> >> >> > the GSH.
> >>>  >>  >> >
> >>> >> >> > The goal  is to be able to cut the  amantadine by 35 - 50%
> > within
> >>> >> >> > 6
> >>> >> >  months.
> >>> >> >>  > My view is the longer I  stay away from starting the agonists,
> >> the
> >>> >>  > better.
> >>> >> >> >
> >>> >>  >> >  Hope that helps.
> >>> >> >>  >
> >>> >> >> >
> >>> >>   >> >
> >>> >> >> > Joh
> >>>  >> >> >
> >>> >>  >>  >
> >>> >> >>
> >>>
> >>>  >>  >
> > ----------------------------------------------------------------------
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> >>> >>  >> >  [log in to unmask]
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> >>> >>  >> >
> >>> >>  >>
> >>>  >>
> >>> >> >>
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> >>> >
> >>> >
> >>> >
> >>> >  **************Remember Mom this Mother's Day! Find a florist 
> near 
> >>> > you
> >> now.
> >>> >
> >>
> > (http://yellowpages.aol.com/search?query=florist&ncid=emlcntusyelp00000006)
> >>>  >
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