Doesn't Tyrosine increase blood pressure?
 
Roberta Innarella


In a message dated 5/7/2009 2:01:57 A.M. Eastern Daylight Time,  
[log in to unmask] writes:

Yep!

----- Original Message -----
From:  "rayilynlee" <[log in to unmask]>
To:  <[log in to unmask]>
Sent: Tuesday, May 05, 2009  9:45 AM
Subject: Re: Question re milk thistle


> gee, I  didn't know milk thistle would help my liver produce dopamine.   I
> started taking it for constipation.  Do I need to take  tyrosine with it?
>
> Ray
>
> Rayilyn  Brown
> Director AZNPF
> Arizona Chapter National Parkinson  Foundation
> [log in to unmask]
>
>  --------------------------------------------------
> From: "Schaaf  Angus / Meadow Creek Ranch" <[log in to unmask]>
> Sent:  Tuesday, May 05, 2009 8:40 AM
> To:  <[log in to unmask]>
> Subject: Question re  Amantadine/  GSH importance
>
> > Couple of  thoughts.
> > Have you tried to let your liver produce your  dopamine needs by taking
> > tyrosine and milk thistle?
>  > The natural production of GSH  by the body is a little more  
complicated
> > but
> > following is article from my  archives that helps explain.
> >      WHY  GSH
> > Oxidative stress appears to play an important role in  degeneration of
> > dopaminergic neurons of the substantia  nigra (SN) associated with
> > Parkinson's disease (PD). The SN  of early PD patients have dramatically
> > decreased levels of  the thiol tripeptide glutathione (GSH). GSH plays
> > multiple  roles in the nervous system both as an antioxidant and a redox
>  > modulator. We have generated dopaminergic PC12 cell lines in  which
levels
> > of
> > GSH can be inducibly  down-regulated via doxycycline induction of
antisense
> >  messages against both the heavy and light subunits of
> >  gamma-glutamyl-cysteine synthetase, the rate-limiting enzyme in
>  > glutathione
> > synthesis. Down-regulation of  glutamyl-cysteine synthetase results in
> > reduction in  mitochondrial GSH levels, increased oxidative stress, and
> >  decreased mitochondrial function. Interestingly, decreases in
>  > mitochondrial
> > activities in GSH-depleted PC12 cells  appears to be because of a
selective
> > inhibition of  complex I activity as a result of thiol oxidation. These
> >  results suggest that the early observed GSH losses in the SN may  be
> > directly
> > responsible for the noted  decreases in complex I activity and the
> > subsequent
>  > mitochondrial dysfunction, which ultimately leads to dopaminergic  cell
> > death
> > associated with PD.
>  >
> >   WHY GLUTAMINE
> > Glutamine is an  important mitochondrial substrate implicated in the
> >  protection of cells from oxidant injury. Human pulmonary  
epithelial-like
> > (A549) cells were exposed to 95% O(2) for 4  days in the absence and
> > presence
> > of glutamine.  Cell proliferation in normoxia was dependent on 
glutamine,
> >  and
> > glutamine deprivation markedly accelerated cell death  in hyperoxia.
> > Glutamine significantly increased cellular  ATP levels in normoxia and
> > prevented the loss of ATP in  hyperoxia seen in glutamine-deprived 
cells.
> > Mitochondrial  membrane potential as assessed by flow cytometry with
> >  chloromethyltetramethylrosamine was increased by glutamine in
>  > hyperoxia-exposed A549 cells, and a glutamine dose-dependent  increase 
in
> > mitochondrial membrane potential was detected.  Glutamine-supplemented,
> > hyperoxia-exposed cells had a  HIGHER  O(2) consumption rate and GSH
> > content.
>  > Electron and fluorescence microscopy revealed that, in  hyperoxia,
> > glutamine
> > protected cellular  structures, especially mitochondria, from damage. In
> >  hyperoxia, activity of the tricarboxylic acid cycle enzyme
> >  alpha-ketoglutarate dehydrogenase was partially protected by  its
indirect
> > substrate, glutamine, indicating a  mechanism of mitochondrial
protection.
> > THEREFORE:   I take L-Glutamine and DHEA to increase the level of GSH in
> >  the
> > body naturally to further thwart the symptoms and  destruction of P.D.
> > along
> > with my other  vitamin/mineral protocol which exclude PD drugs. As a
note.
>  > I
> > never tried the Amantadine. My doctors forced me  early to look 
elsewhere
> > for
> > help since they  couldnt due to lack of knowledge or incentive. Not sure
> >  which but I'm alot healthier for switching to a no drug  protocol.
> >
> > ----- Original Message -----
>  > From: "Ernesto Divo" <[log in to unmask]>
> > To:  <[log in to unmask]>
> > Sent: Sunday, May 03,  2009 12:24 PM
> > Subject: Re: Question re Amantadine  use
> >
> >
> >> Hi John,
>  >>
> >> I'm 56 and was diagnosed with PD in 2000, I've  been taking Azilect and
> >> Requip (Ropinirole) the nausea  form the Requip is unbearable.  I have
> >> introduced  to my regimen for the past 5 months or so, 'MaxGXL', a
> >  supplement
> >> developed here in the US, by a US scientist  and sold by a US
> >> company. It raises thet levels of GSH  in your cells naturally. It took
> >> the
> >>  GXL about a week to work on my sleeping pattern, I was waking up  2-3
> >> times
> >> during the night, now I  sleep straight thru the night, and it took
about
> >>  three weeks to work on my cognitive process but it was so subtle  I
barely
> >> thought it was the GXL. I wasn't having  problems looking for words to
> > finish
> >> a  sentence, my memory is back, I don't lose things around the house,  
I
> > have
> >> more energy and I feel good and my  wife is happier.  It is strange,
when
> >> I
>  >> asked my doctor about it he said Gluta what?  it seems the  medical
> > community
> >> is keeping the use of  Glutathione (GSH) under wraps, they don't want
> >>  competition...  I order mine from www.maxgxl.com/133282  I  suggest
> >> getting
> >> as much info as  possible of GSH, I went to www.youtube.com and 
searched
> >  for
> >> 'The mother of all antioxidants', there is this  doctor Mark Hyman who
> >> explains in details about GSH;  excellent video.
> >>
> >> Good luck to  you.
> >>
> >> Ernesto,
> >> Miami,  FL
> >>
> >> On Sat, May 2, 2009 at 11:46 AM,  john emrys <[log in to unmask]>
> > wrote:
>  >>
> >> > Hey John
> >> >
>  >> > I've been on Amantadine since being diagnosed in October  of last
year;
> >> > dosage has remained constant and  titrated from 100mg to 300mg per
day,
> > over
>  >> > an initial period of 3 weeks.
> >>  >
> >> > I space the dosing about 5-ish hours apart;  I've found if the final
> >> > dose
> >  of
> >> > 100mg is taken later than 8PM, I have trouble  sleeping through the
> > night.
> >> >
>  >> > It does give me an energy boost and some minor relief from  muscle
> >> > tightness, but does nothing to improve gait  or reduce tremor. It's
sort
> > of
> >> >  just a little bit of "gas" for your "engine."
> >>  >
> >> > On the other hand, I find it causes auditory  hallucinations,
> >> > drowsiness,
> >> >  occasional vertigo, foggy thought processing and swelling around  
the
> > knees.
> >> >
> >> > I  find much better results on GSH and mucuna bean, which I started
>  >> > about
> > 6
> >> > months ago (the  mucuna has been a very recent thing, so it's been 
too
> >  early
> >> > to tell – but so far, I'm definitely  impressed). My neuro 
practically
> > lit
> >> >  his own hair on fire when I told him, but he couldn't deny  the
results
> > of
> >> > the GSH.
>  >> >
> >> > The goal is to be able to cut the  amantadine by 35 - 50% within 6
> > months.
> >>  > My view is the longer I stay away from starting the agonists,  the
> > better.
> >> >
> >> >  Hope that helps.
> >> >
> >> >
>  >> >
> >> > Joh
> >> >
>  >> >
> >>
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