Schaff:

I ordered 1000 msg milk thistle and 500 msg L-tyrosine - is that the correct 
amount or not?
thanks so much and for clarifying the bp issue.  I  couldn't find anything 
on line that said tyrosine caused high bp - and yes it did claim these 2 
supplements as treatment for PD.  thanks so very much

here's hoping....I don't take PD meds you know, but am getting worse

Ray

Rayilyn Brown
Director AZNPF
Arizona Chapter National Parkinson Foundation
[log in to unmask]

--------------------------------------------------
From: "Schaaf Angus / Meadow Creek Ranch" <[log in to unmask]>
Sent: Sunday, May 10, 2009 8:09 PM
To: <[log in to unmask]>
Subject: Re: Question re milk thistleand tyrosine

> To the best of my knowledge tyrosine has no impact on blood pressure. It 
> is
> a precursor necessary for the production of dopamine by the liver. It is
> quite beneficial. Salt and sugar as well as poor diets have more impact on
> BP .
> Hope this helps.
> If it werent for tyrosine in my program I couldnt do the 5 to 6 hours of
> walking I've been doing the last few days fixing storm damage on the ranch
> fences. Needless to say by sundown I'm really wornout for the day.
> Have a good Sunday Ray.
>
> ----- Original Message -----
> From: "rayilynlee" <[log in to unmask]>
> To: <[log in to unmask]>
> Sent: Friday, May 08, 2009 10:48 AM
> Subject: Re: Question re milk thistle
>
>
>> thanks Roberta  - I take bp medication
>> Ray
>>
>> Rayilyn Brown
>> Director AZNPF
>> Arizona Chapter National Parkinson Foundation
>> [log in to unmask]
>>
>> --------------------------------------------------
>> From: <[log in to unmask]>
>> Sent: Thursday, May 07, 2009 4:03 AM
>> To: <[log in to unmask]>
>> Subject: Re: Question re milk thistle
>>
>> >
>> >
>> > Doesn't Tyrosine increase blood pressure?
>> >
>> > Roberta Innarella
>> >
>> >
>> > In a message dated 5/7/2009 2:01:57 A.M. Eastern Daylight Time,
>> > [log in to unmask] writes:
>> >
>> > Yep!
>> >
>> > ----- Original Message -----
>> > From:  "rayilynlee" <[log in to unmask]>
>> > To:  <[log in to unmask]>
>> > Sent: Tuesday, May 05, 2009  9:45 AM
>> > Subject: Re: Question re milk thistle
>> >
>> >
>> >> gee, I  didn't know milk thistle would help my liver produce dopamine.
>> >> I
>> >> started taking it for constipation.  Do I need to take  tyrosine with
> it?
>> >>
>> >> Ray
>> >>
>> >> Rayilyn  Brown
>> >> Director AZNPF
>> >> Arizona Chapter National Parkinson  Foundation
>> >> [log in to unmask]
>> >>
>> >>  --------------------------------------------------
>> >> From: "Schaaf  Angus / Meadow Creek Ranch" <[log in to unmask]>
>> >> Sent:  Tuesday, May 05, 2009 8:40 AM
>> >> To:  <[log in to unmask]>
>> >> Subject: Question re  Amantadine/  GSH importance
>> >>
>> >> > Couple of  thoughts.
>> >> > Have you tried to let your liver produce your  dopamine needs by
> taking
>> >> > tyrosine and milk thistle?
>> >>  > The natural production of GSH  by the body is a little more
>> > complicated
>> >> > but
>> >> > following is article from my  archives that helps explain.
>> >> >      WHY  GSH
>> >> > Oxidative stress appears to play an important role in  degeneration
> of
>> >> > dopaminergic neurons of the substantia  nigra (SN) associated with
>> >> > Parkinson's disease (PD). The SN  of early PD patients have
>> >> > dramatically
>> >> > decreased levels of  the thiol tripeptide glutathione (GSH). GSH
> plays
>> >> > multiple  roles in the nervous system both as an antioxidant and a
>> >> > redox
>> >>  > modulator. We have generated dopaminergic PC12 cell lines in  which
>> > levels
>> >> > of
>> >> > GSH can be inducibly  down-regulated via doxycycline induction of
>> > antisense
>> >> >  messages against both the heavy and light subunits of
>> >> >  gamma-glutamyl-cysteine synthetase, the rate-limiting enzyme in
>> >>  > glutathione
>> >> > synthesis. Down-regulation of  glutamyl-cysteine synthetase results
> in
>> >> > reduction in  mitochondrial GSH levels, increased oxidative stress,
> and
>> >> >  decreased mitochondrial function. Interestingly, decreases in
>> >>  > mitochondrial
>> >> > activities in GSH-depleted PC12 cells  appears to be because of a
>> > selective
>> >> > inhibition of  complex I activity as a result of thiol oxidation.
> These
>> >> >  results suggest that the early observed GSH losses in the SN may 
>> >> > be
>> >> > directly
>> >> > responsible for the noted  decreases in complex I activity and the
>> >> > subsequent
>> >>  > mitochondrial dysfunction, which ultimately leads to dopaminergic
>> >> cell
>> >> > death
>> >> > associated with PD.
>> >>  >
>> >> >   WHY GLUTAMINE
>> >> > Glutamine is an  important mitochondrial substrate implicated in the
>> >> >  protection of cells from oxidant injury. Human pulmonary
>> > epithelial-like
>> >> > (A549) cells were exposed to 95% O(2) for 4  days in the absence and
>> >> > presence
>> >> > of glutamine.  Cell proliferation in normoxia was dependent on
>> > glutamine,
>> >> >  and
>> >> > glutamine deprivation markedly accelerated cell death  in hyperoxia.
>> >> > Glutamine significantly increased cellular  ATP levels in normoxia
> and
>> >> > prevented the loss of ATP in  hyperoxia seen in glutamine-deprived
>> > cells.
>> >> > Mitochondrial  membrane potential as assessed by flow cytometry with
>> >> >  chloromethyltetramethylrosamine was increased by glutamine in
>> >>  > hyperoxia-exposed A549 cells, and a glutamine dose-dependent
> increase
>> > in
>> >> > mitochondrial membrane potential was detected.
> Glutamine-supplemented,
>> >> > hyperoxia-exposed cells had a  HIGHER  O(2) consumption rate and GSH
>> >> > content.
>> >>  > Electron and fluorescence microscopy revealed that, in  hyperoxia,
>> >> > glutamine
>> >> > protected cellular  structures, especially mitochondria, from 
>> >> > damage.
>> >> > In
>> >> >  hyperoxia, activity of the tricarboxylic acid cycle enzyme
>> >> >  alpha-ketoglutarate dehydrogenase was partially protected by  its
>> > indirect
>> >> > substrate, glutamine, indicating a  mechanism of mitochondrial
>> > protection.
>> >> > THEREFORE:   I take L-Glutamine and DHEA to increase the level of 
>> >> > GSH
>> >> > in
>> >> >  the
>> >> > body naturally to further thwart the symptoms and  destruction of
> P.D.
>> >> > along
>> >> > with my other  vitamin/mineral protocol which exclude PD drugs. As a
>> > note.
>> >>  > I
>> >> > never tried the Amantadine. My doctors forced me  early to look
>> > elsewhere
>> >> > for
>> >> > help since they  couldnt due to lack of knowledge or incentive. Not
>> >> > sure
>> >> >  which but I'm alot healthier for switching to a no drug  protocol.
>> >> >
>> >> > ----- Original Message -----
>> >>  > From: "Ernesto Divo" <[log in to unmask]>
>> >> > To:  <[log in to unmask]>
>> >> > Sent: Sunday, May 03,  2009 12:24 PM
>> >> > Subject: Re: Question re Amantadine  use
>> >> >
>> >> >
>> >> >> Hi John,
>> >>  >>
>> >> >> I'm 56 and was diagnosed with PD in 2000, I've  been taking Azilect
>> >> >> and
>> >> >> Requip (Ropinirole) the nausea  form the Requip is unbearable.  I
> have
>> >> >> introduced  to my regimen for the past 5 months or so, 'MaxGXL', a
>> >> >  supplement
>> >> >> developed here in the US, by a US scientist  and sold by a US
>> >> >> company. It raises thet levels of GSH  in your cells naturally. It
>> >> >> took
>> >> >> the
>> >> >>  GXL about a week to work on my sleeping pattern, I was waking up
> 2-3
>> >> >> times
>> >> >> during the night, now I  sleep straight thru the night, and it took
>> > about
>> >> >>  three weeks to work on my cognitive process but it was so subtle 
>> >> >> I
>> > barely
>> >> >> thought it was the GXL. I wasn't having  problems looking for words
> to
>> >> > finish
>> >> >> a  sentence, my memory is back, I don't lose things around the
> house,
>> > I
>> >> > have
>> >> >> more energy and I feel good and my  wife is happier.  It is 
>> >> >> strange,
>> > when
>> >> >> I
>> >>  >> asked my doctor about it he said Gluta what?  it seems the 
>> >> medical
>> >> > community
>> >> >> is keeping the use of  Glutathione (GSH) under wraps, they don't
> want
>> >> >>  competition...  I order mine from www.maxgxl.com/133282  I 
>> >> >> suggest
>> >> >> getting
>> >> >> as much info as  possible of GSH, I went to www.youtube.com and
>> > searched
>> >> >  for
>> >> >> 'The mother of all antioxidants', there is this  doctor Mark Hyman
> who
>> >> >> explains in details about GSH;  excellent video.
>> >> >>
>> >> >> Good luck to  you.
>> >> >>
>> >> >> Ernesto,
>> >> >> Miami,  FL
>> >> >>
>> >> >> On Sat, May 2, 2009 at 11:46 AM,  john emrys
> <[log in to unmask]>
>> >> > wrote:
>> >>  >>
>> >> >> > Hey John
>> >> >> >
>> >>  >> > I've been on Amantadine since being diagnosed in October  of 
>> >> last
>> > year;
>> >> >> > dosage has remained constant and  titrated from 100mg to 300mg 
>> >> >> > per
>> > day,
>> >> > over
>> >>  >> > an initial period of 3 weeks.
>> >> >>  >
>> >> >> > I space the dosing about 5-ish hours apart;  I've found if the
> final
>> >> >> > dose
>> >> >  of
>> >> >> > 100mg is taken later than 8PM, I have trouble  sleeping through
> the
>> >> > night.
>> >> >> >
>> >>  >> > It does give me an energy boost and some minor relief from
> muscle
>> >> >> > tightness, but does nothing to improve gait  or reduce tremor.
> It's
>> > sort
>> >> > of
>> >> >> >  just a little bit of "gas" for your "engine."
>> >> >>  >
>> >> >> > On the other hand, I find it causes auditory  hallucinations,
>> >> >> > drowsiness,
>> >> >> >  occasional vertigo, foggy thought processing and swelling around
>> > the
>> >> > knees.
>> >> >> >
>> >> >> > I  find much better results on GSH and mucuna bean, which I
> started
>> >>  >> > about
>> >> > 6
>> >> >> > months ago (the  mucuna has been a very recent thing, so it's 
>> >> >> > been
>> > too
>> >> >  early
>> >> >> > to tell – but so far, I'm definitely  impressed). My neuro
>> > practically
>> >> > lit
>> >> >> >  his own hair on fire when I told him, but he couldn't deny  the
>> > results
>> >> > of
>> >> >> > the GSH.
>> >>  >> >
>> >> >> > The goal is to be able to cut the  amantadine by 35 - 50% within 
>> >> >> > 6
>> >> > months.
>> >> >>  > My view is the longer I stay away from starting the agonists,
> the
>> >> > better.
>> >> >> >
>> >> >> >  Hope that helps.
>> >> >> >
>> >> >> >
>> >>  >> >
>> >> >> > Joh
>> >> >> >
>> >>  >> >
>> >> >>
>> 
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>> >
>> > **************Remember Mom this Mother's Day! Find a florist near you
> now.
>> >
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