Oh boy, Ray.  Wouldn't that be a great side effect. Let me know and  maybe 
I'll try it.
 
Roberta Innarella  

 
In a message dated 5/13/2009 2:00:52 A.M. Eastern Daylight Time,  
[log in to unmask] writes:

Roberta

I don't take any MAO inhibitors or much else so the  tyrosine is most 
likely 
OK for me.  thanks for clarifying the  issue.  It would be great if I could 
lose some fat.
Ray
Rayilyn  Brown
Director AZNPF
Arizona Chapter National Parkinson  Foundation
[log in to unmask]

--------------------------------------------------
From:  <[log in to unmask]>
Sent: Sunday, May 10, 2009 8:23 AM
To:  <[log in to unmask]>
Subject: Re: Question re milk  thistleand tyrosine

>
>
> The following taken from  "Prescription for Nutritional Healing" Third
> Edition:
>
>  "Tyrosine is important to overall metabolism.  It is a precursor   of
> adrenaline and the neurotransmiters norepinephrine and dopamine,  which 
> regulate
> mood and stimulate metabolism and the nervous  system.   Tyrosine acts as 
a
> mood elevator; a lack of  adequate amounts of tyrosine  leads to a 
> deficiency
> of  norepinephrine in the brain, which in turn can  result in depression. 
 
> It
> also acts as a mild antioxidant, suppresses  the  appetite, and helps to
> reduce body fat.  It aids in the   production of melanin (the pigment 
> responsible
> for skin and  hair color)  and in the functions of the adrenal, thyroid, 
>  and
> pituitary glands.   It is also involved in the  metabolism of the amino 
> acid
> phenylalanine.
>
>  Tyrosine attaches to iodine atoms to form active thyroid  hormones.   Not
> surprisingly, therefore, low plasma levels of tyrosine  have  been 
> associated
> with hypothyroidism.  Symptoms of  tyrosine  deficiency can also include 
> low
> blood  pressure, low body temperature (such  as cold hands and feet),  and
> restless leg syndrome.
>
> Supplemental L-tyrosine has  been used for stress reduction, and  research
> suggests it may be  helpful against chronic fatigue and  narcolepsy.  It 
>  has
> been used to help individuals suffering from  anxiety,  depression, low 
sex
> drive, allergies, and headaches, as well as   persons undergoing 
withdrawal
> from drugs.  It may also help  people  with Parkinson's disease.
>
> Natural resources of  tyrosine include almonds, avocados, bananas,  dairy
> products,  lima beans, pumpkin seeds, and sesame seeds.   Tyrosine can 
also  
> be
> produced from phenylalanine in the body.    Supplements of L-tyrosine 
> should
> be taken at bedtime or with  a  high-carbohydrate meal so that it does not
> have to complete  for absorption  with other amino acids.
>
> Persons taking  monoamine oxidase (MAO)) inhibitors, commonly  prescribed
> for  depression, must strictly limit their intake of foods  containing  
> tyrosine
> and should not take any supplements  containing  L-tyrosine, as it may 
lead
> to a sudden and dangerous rise in   blood pressure.  Anyone who takes
> prescription medication  for  depression should discuss necessary dietary
> restrictions  with his or her  physician."
>
> I take Azilect which is an  MOA (B) not (A) inhibitor so I don't know  if
> the last paragraph  would apply as I obviously don't take it for 
> depression
> but  for PD.  I guess I'll need to research further unless  anyone on  
this
> forum knows the answer.
>
> Roberta  Innarella
>
>
> In a message dated 5/10/2009 3:27:33 A.M.  Eastern Daylight Time,
> [log in to unmask] writes:
>
>  Schaff:
>
> I ordered 1000 msg milk thistle and 500 msg   L-tyrosine - is that the
> correct
> amount or not?
> thanks  so much  and for clarifying the bp issue.  I  couldn't find  
> anything
>
> on line that said tyrosine caused high bp -  and yes it did claim  these 2
> supplements as treatment for  PD.  thanks so very  much
>
> here's hoping....I don't  take PD meds you know, but am  getting worse
>
>  Ray
>
> Rayilyn Brown
> Director  AZNPF
> Arizona  Chapter National Parkinson  Foundation
>  [log in to unmask]
>
>  --------------------------------------------------
> From:  "Schaaf  Angus / Meadow Creek Ranch" <[log in to unmask]>
> Sent:   Sunday, May 10, 2009 8:09 PM
> To:   <[log in to unmask]>
> Subject: Re: Question re  milk  thistleand tyrosine
>
>> To the best of my knowledge  tyrosine has  no impact on blood pressure. 
It
>> is
>>  a precursor  necessary for the production of dopamine by the liver. It  
is
>>  quite beneficial. Salt and sugar as well as poor diets  have more impact
> on
>> BP .
>> Hope this  helps.
>> If it werent for  tyrosine in my program I couldnt do  the 5 to 6 hours 
of
>> walking  I've been doing the last few  days fixing storm damage on the
> ranch
>> fences. Needless to  say by sundown I'm really wornout for  the day.
>> Have a good  Sunday Ray.
>>
>> ----- Original  Message  -----
>> From: "rayilynlee"   <[log in to unmask]>
>> To:   <[log in to unmask]>
>> Sent: Friday, May 08,  2009  10:48 AM
>> Subject: Re: Question re milk   thistle
>>
>>
>>> thanks Roberta  - I take  bp  medication
>>> Ray
>>>
>>>  Rayilyn  Brown
>>> Director AZNPF
>>> Arizona  Chapter National  Parkinson Foundation
>>>   [log in to unmask]
>>>
>>>   --------------------------------------------------
>>> From:   <[log in to unmask]>
>>> Sent: Thursday, May 07, 2009  4:03  AM
>>> To:  <[log in to unmask]>
>>>  Subject: Re:  Question re milk thistle
>>>
>>>   >
>>> >
>>> > Doesn't Tyrosine increase  blood  pressure?
>>> >
>>> > Roberta   Innarella
>>> >
>>> >
>>> > In  a  message dated 5/7/2009 2:01:57 A.M. Eastern Daylight  Time,
>>>  > [log in to unmask] writes:
>>>  >
>>> >  Yep!
>>> >
>>> >  ----- Original Message  -----
>>> > From:   "rayilynlee"  <[log in to unmask]>
>>> >  To:   <[log in to unmask]>
>>> >  Sent: Tuesday,  May 05, 2009  9:45 AM
>>> > Subject:  Re: Question re  milk thistle
>>> >
>>>  >
>>> >> gee,  I  didn't know milk thistle  would help my liver produce
> dopamine.
>>> >>  I
>>> >> started taking it  for constipation.  Do  I need to take  tyrosine 
>>> >> with
>>   it?
>>> >>
>>> >>  Ray
>>>  >>
>>> >> Rayilyn   Brown
>>> >>  Director AZNPF
>>> >>  Arizona Chapter National  Parkinson  Foundation
>>>  >>  [log in to unmask]
>>> >>
>>>  >>    --------------------------------------------------
>>>  >>  From: "Schaaf  Angus / Meadow Creek Ranch"   <[log in to unmask]>
>>> >> Sent:  Tuesday,  May  05, 2009 8:40 AM
>>> >> To:    <[log in to unmask]>
>>> >> Subject:   Question re  Amantadine/  GSH importance
>>>   >>
>>> >> > Couple of   thoughts.
>>>  >> > Have you tried to let your liver  produce your   dopamine needs by
>> taking
>>>  >> > tyrosine and  milk thistle?
>>> >>   > The natural production of  GSH  by the body is a little  more
>>> >  complicated
>>> >> >  but
>>> >> >  following is article from my   archives that helps  explain.
>>> >> >     WHY   GSH
>>> >> > Oxidative stress  appears to play an  important role in 
>>> >> >  degeneration
>> of
>>> >>  > dopaminergic  neurons of the substantia  nigra (SN) associated 
>>>  >> with
>>> >> > Parkinson's disease (PD). The  SN  of  early PD patients have
>>> >> >   dramatically
>>> >> > decreased levels of  the   thiol tripeptide glutathione (GSH). GSH
>>  plays
>>>  >> > multiple  roles in the nervous  system both as an  antioxidant 
and 
>>> a
>>>  >> > redox
>>>  >>  > modulator. We  have generated dopaminergic PC12 cell  lines in
>  which
>>> > levels
>>> >> >   of
>>> >> > GSH can be inducibly   down-regulated  via doxycycline induction of
>>> >  antisense
>>>  >> >  messages against both the  heavy and light subunits  of
>>> >> >   gamma-glutamyl-cysteine synthetase,  the rate-limiting enzyme  in
>>> >>  >  glutathione
>>>  >> > synthesis. Down-regulation  of  glutamyl-cysteine  synthetase 
>>> >> > results
>>  in
>>>  >> > reduction in  mitochondrial GSH  levels, increased  oxidative
> stress,
>>  and
>>> >> >  decreased  mitochondrial  function. Interestingly, decreases in
>>>  >>   > mitochondrial
>>> >> > activities  in  GSH-depleted PC12 cells  appears to be because of a
>>>   > selective
>>> >> > inhibition of  complex  I  activity as a result of thiol oxidation.
>>  These
>>>  >> >  results suggest that the early  observed GSH losses  in the SN 
may
>>> >> >  be
>>> >> >  directly
>>> >> >  responsible for the noted   decreases in complex I activity and  
the
>>> >> >  subsequent
>>>  >>  > mitochondrial dysfunction,  which ultimately leads to  
dopaminergic
>>> >>  cell
>>> >> >  death
>>> >> >  associated with PD.
>>>  >>  >
>>> >>  >   WHY  GLUTAMINE
>>> >> > Glutamine is  an  important  mitochondrial substrate implicated in
> the
>>>   >> >  protection of cells from oxidant injury. Human   pulmonary
>>> > epithelial-like
>>> >>  >  (A549) cells were exposed to 95% O(2) for 4  days in the  absence
> and
>>> >> > presence
>>>  >> > of  glutamine.  Cell proliferation in normoxia was  dependent  on
>>> > glutamine,
>>> >>  >   and
>>> >> > glutamine deprivation  markedly accelerated  cell death  in
>  hyperoxia.
>>> >> > Glutamine  significantly  increased cellular  ATP levels in 
normoxia
>>   and
>>> >> > prevented the loss of ATP in    hyperoxia seen in 
glutamine-deprived
>>> >  cells.
>>>  >> > Mitochondrial  membrane  potential as assessed by flow  cytometry
> with
>>>  >> >   chloromethyltetramethylrosamine was increased by  glutamine  in
>>> >>  > hyperoxia-exposed A549  cells, and a  glutamine dose-dependent
>>  increase
>>> >  in
>>> >> >  mitochondrial membrane potential was  detected.
>>  Glutamine-supplemented,
>>> >> >  hyperoxia-exposed  cells had a  HIGHER  O(2) consumption rate  and
>  GSH
>>> >> > content.
>>>  >>   > Electron and fluorescence microscopy revealed that,  in
> hyperoxia,
>>> >> > glutamine
>>>  >> >  protected cellular  structures, especially  mitochondria, from
>>> >> > damage.
>>>  >> >  In
>>> >> >  hyperoxia, activity  of the  tricarboxylic acid cycle enzyme
>>> >>  >   alpha-ketoglutarate dehydrogenase was partially protected by  
>>> >> > its
>>> >  indirect
>>> >> > substrate,  glutamine, indicating  a  mechanism of mitochondrial
>>>  >  protection.
>>> >> > THEREFORE:   I take   L-Glutamine and DHEA to increase the level of
>>> >>  >  GSH
>>> >> > in
>>> >>  >   the
>>> >> > body naturally to further  thwart the  symptoms and  destruction of
>>  P.D.
>>> >> >  along
>>> >> >  with my other  vitamin/mineral  protocol which exclude PD drugs.  
As
> a
>>> > note.
>>>  >>   > I
>>> >> > never tried the  Amantadine. My  doctors forced me  early to look
>>> >   elsewhere
>>> >> > for
>>> >> >  help  since they  couldnt due to lack of knowledge or  incentive.
> Not
>>> >> > sure
>>>  >> >  which  but I'm alot healthier for switching to a no  drug
> protocol.
>>> >> >
>>> >>  > -----  Original Message -----
>>> >>  >  From: "Ernesto  Divo" <[log in to unmask]>
>>>  >> > To:    <[log in to unmask]>
>>> >> >  Sent:  Sunday, May 03,  2009 12:24 PM
>>> >> >  Subject:  Re: Question re Amantadine  use
>>>  >>  >
>>> >> >
>>> >>  >> Hi  John,
>>> >>   >>
>>> >> >>  I'm 56 and was diagnosed with  PD in 2000, I've  been taking
> Azilect
>>> >>  >> and
>>> >> >>  Requip (Ropinirole) the  nausea  form the Requip is  unbearable. 
>>> >>  >> I
>> have
>>> >> >>   introduced  to my regimen for the past 5 months or so, 'MaxGXL',
>  a
>>> >> >  supplement
>>>  >>  >> developed here in the US, by a US scientist  and  sold by a  US
>>> >> >> company. It raises thet  levels of  GSH  in your cells naturally. 
>>> >>  >> It
>>> >> >>  took
>>>  >> >> the
>>> >>  >>  GXL about  a week to work on my sleeping pattern, I was  waking 
>>>  >> up
>> 2-3
>>> >> >>  times
>>>  >> >> during the night, now I   sleep straight thru the  night, and it
> took
>>> >  about
>>> >>  >>  three weeks to work on my  cognitive process but it was so
> subtle
>>> >>  >> I
>>> >  barely
>>> >> >>  thought it was the GXL. I wasn't  having  problems looking  for
> words
>> to
>>> >>  >  finish
>>> >> >> a  sentence, my memory is   back, I don't lose things around the
>> house,
>>>  >  I
>>> >> > have
>>> >>  >> more  energy and I feel good and my  wife is happier.   It is
>>> >> >> strange,
>>> >   when
>>> >> >> I
>>> >>   >>  asked my doctor about it he said Gluta what?  it seems  the
>>> >> medical
>>> >> >   community
>>> >> >> is keeping the use of    Glutathione (GSH) under wraps, they don't
>>  want
>>>  >> >>  competition...  I  order mine from  www.maxgxl.com/133282  I
>>> >>  >>  suggest
>>> >> >>  getting
>>> >>  >> as much info as  possible  of GSH, I went to  www.youtube.com and
>>> >  searched
>>> >>  >  for
>>>  >> >> 'The mother of all  antioxidants', there is this   doctor Mark 
>>> >> >> Hyman
>>   who
>>> >> >> explains in details about  GSH;   excellent video.
>>> >>  >>
>>> >>  >> Good luck to   you.
>>> >>  >>
>>> >> >>  Ernesto,
>>> >>  >> Miami,   FL
>>> >> >>
>>>  >> >>  On Sat, May 2, 2009 at 11:46 AM,  john  emrys
>>  <[log in to unmask]>
>>> >> >   wrote:
>>> >>  >>
>>> >>  >>  > Hey John
>>> >> >>  >
>>>  >>  >> > I've been on  Amantadine since being  diagnosed in October  of
>>>  >> last
>>>  > year;
>>> >>  >> > dosage has remained  constant and  titrated from 100mg  to 
300mg
>>> >>  >> > per
>>> >  day,
>>> >> >  over
>>> >>   >> > an initial period of 3  weeks.
>>> >>  >>  >
>>> >>  >> > I space the  dosing about 5-ish hours apart;  I've  found if 
the
>>  final
>>> >> >> >  dose
>>>  >> >  of
>>> >> >>  > 100mg is  taken later than 8PM, I have trouble  sleeping 
>>> >>  >> through
>> the
>>> >> >  night.
>>>  >> >> >
>>>  >>  >> > It does  give me an energy boost and some  minor relief from
>>  muscle
>>> >> >>  > tightness, but does nothing to  improve gait  or reduce  
tremor.
>> It's
>>> >  sort
>>>  >> > of
>>> >> >>  >  just a  little bit of "gas" for your "engine."
>>>  >>  >>  >
>>> >> >> > On the  other  hand, I find it causes auditory  hallucinations,
>>>   >> >> > drowsiness,
>>> >> >>   >  occasional vertigo, foggy thought processing and swelling
>  around
>>> > the
>>> >> >  knees.
>>>  >> >> >
>>> >>  >> > I  find  much better results on GSH and mucuna bean,  which I
>>  started
>>> >>  >> >  about
>>>  >> > 6
>>> >> >>  > months ago (the   mucuna has been a very recent thing, so  it's
>>> >>  >> > been
>>> >  too
>>> >> >   early
>>> >>  >> > to tell – but so far, I'm  definitely  impressed). My  neuro
>>> >  practically
>>> >> >  lit
>>> >> >>  >  his own hair on fire  when I told him, but he couldn't  deny
> the
>>> >  results
>>> >> >  of
>>> >>  >> > the GSH.
>>>  >>  >>  >
>>> >> >> > The goal  is to be able to  cut the  amantadine by 35 - 50%
> within
>>> >>  >> > 6
>>> >> >  months.
>>>  >> >>  > My view is the longer I  stay away from  starting the 
agonists,
>> the
>>> >>  >  better.
>>> >> >> >
>>> >>   >> >  Hope that helps.
>>> >> >>   >
>>> >> >> >
>>>  >>   >> >
>>> >> >> >  Joh
>>>  >> >> >
>>>  >>  >>  >
>>> >>  >>
>>>
>>>  >>  >
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