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Trauti,
boy is this depressing!! It seems that there is little or no organized
focus on our goals. This is why I don't expect a cure in my lifetime.
Ray
Rayilyn Brown
Director AZNPF
Arizona Chapter National Parkinson Foundation
[log in to unmask]
--------------------------------------------------
From: "Trauti Boyd" <[log in to unmask]>
Sent: Saturday, June 06, 2009 5:22 AM
To: <[log in to unmask]>
Subject: Re: Spinal Cord Stimulator Sparks Hope For Parkinson's Disease
Treatment
> hi paul, sorry to say there seems to be no straight-forward answer. having
> read about the initial success with mice i asked my husband's neurologist
> who is head of the movement disorder clinic at DUKE what he thought the
> time line would be and, low and behold, he had not even heard of this
> research going on at his institution. i was dumbfounded. sometimes i
> wonder if there ever will be actual progress made.
> trauti
> ----- Original Message -----
> From: <[log in to unmask]>
> To: <[log in to unmask]>
> Sent: Friday, June 05, 2009 8:36 PM
> Subject: Re: Spinal Cord Stimulator Sparks Hope For Parkinson's Disease
> Treatment
>
>
>> And I'll ask more or less the same question I asked a month ago. When is
>> the next step to be taken? I guess I just don't understand the world (and
>> maybe the rules or mores) of scientific research. Will someone start
>> investigating the process with humans only if there is profit on the
>> horizon? Sure
>> doesn't fit my type A personality! Why doesn't a PD Organization fund
>> it. Or
>> maybe Ali or Fox if their Foundations can afford it. If I could afford
>> it
>> I would! It is so stupidly frustrating to keep reading about mice
>> without a
>> concrete time line reference to humans. And if Apes come first, then GET
>> STARTED. If there were to be a call for Clinical Trial volunteers the
>> line
>> would probably stretch from here to Natal Brazil.
>>
>> Paul H. Lauer
>>
>>
>> In a message dated 6/4/2009 2:00:24 A.M. Eastern Daylight Time,
>> [log in to unmask] writes:
>>
>> thanks for the video, John. I posted this news about a month ago.
>> Ray
>>
>> Rayilyn Brown
>> Director AZNPF
>> Arizona Chapter National Parkinson Foundation
>> [log in to unmask]
>>
>> --------------------------------------------------
>> From: "John Cottingham"
>> <[log in to unmask]>
>> Sent: Wednesday, June 03, 2009 12:07 AM
>> To: <[log in to unmask]>
>> Subject: Spinal Cord Stimulator Sparks Hope For Parkinson's Disease
>> Treatment
>>
>>> New research of stimulation of the spinal cord instead of the brain
>> shows
>>> promise of countering movement disorders associated with Parkinson's
>>> disease.
>>>
>>> Video from Duke University shows what has been accomplished. That video
>> is
>>> on the PIENO maillist page at:
>>>
>>> http://parkinsons-information-exchange-network-online.com/maillist.html
>>>
>>> Perhaps annual additions to the "Hole in the Head Gang" won't be
>> necessary
>>> if this proves to be a viable non-invasive treatment.
>>>
>>> John Cottingham
>>>
>>>
>>>
>>>>Novel Spinal Cord Stimulator Sparks Hope For Parkinson's Disease
>> Treatment
>>>>
>>>>ScienceDaily (Mar. 21, 2009) ­ A novel stimulation method, the
>>>>first
>>>>potential therapy to target the spinal cord instead of the brain, may
>>>>offer an effective and less invasive approach for Parkinson's disease
>>>>treatment, according to pre-clinical data published in the journal
>> Science
>>>>by researchers at Duke University Medical Center.
>>>>
>>>>Researchers developed a prosthetic device that applies electrical
>>>>stimulation to the dorsal column in the spinal cord, which is a main
>>>>sensory pathway carrying tactile information from the body to the
>>>>brain.
>>
>>>>The device was attached to the surface of the spinal cord in mice and
>> rats
>>>>with depleted levels of the chemical dopamine - mimicking the biologic
>>>>characteristics of someone with Parkinson's disease along with the
>>>>impaired motor skills seen in advanced stages of the disease.
>>>>
>>>>When the device was turned on, the dopamine-depleted animals' slow,
>> stiff
>>>>movements were replaced with the active behaviors of healthy mice and
>>>>rats. Improved movement was typically observed within 3.35 seconds
>>>>after
>>
>>>>stimulation.
>>>>
>>>>"We see an almost immediate and dramatic change in the animal's ability
>> to
>>>>function when the device stimulates the spinal cord," says senior study
>>>>investigator Miguel Nicolelis, M.D., Ph.D., the Anne W. Deane Professor
>> of
>>>>Neuroscience at Duke. "Moreover, it is easy to use, significantly less
>>>>invasive than other alternatives to medication, such as deep brain
>>>>stimulation, and has the potential for widespread use in conjunction
>> with
>>>>medications typically used to treat Parkinson's disease."
>>>>
>>>>Researchers tested mice and rats with acute and chronic dopamine
>>>>deficit
>>>>using varying levels of electrical stimulation and in combination with
>>>>different doses of dopamine replacement therapy, also known as
>>>>3,4-dihydroxy-L-phenylalanine or L-DOPA, to determine the most
>>>>effective
>>
>>>>pairing.
>>>>
>>>>When the device was used without additional medication, Parkinsonian
>>>>animals were 26 times more active. When stimulation was coupled with
>>>>medication, only two L-DOPA doses were needed to produce movement
>> compared
>>>>to five doses when the medication was used by itself.
>>>>
>>>>"This work addresses an important need because people living with
>>>>Parkinson's disease face a difficult reality - L-Dopa will eventually
>> stop
>>>>managing the symptoms," explains Romulo Fuentes, a postdoctoral fellow
>> at
>>>>Duke University and lead author of the study. "Patients are left with
>> few
>>>>options for treatment, including electrical stimulation of the brain,
>>>>which is appropriate for only a subset of patients."
>>>>
>>>>While deep brain stimulation (DBS) and other experimental treatments
>>>>attack the disease at its origin - in the brain - Nicolelis and team
>> took
>>>>a different approach. The concept for the device began when researchers
>>>>made a surprising connection with another neurological condition.
>>>>
>>>>"It was a moment of sudden insight," explains Nicolelis. "We were
>>>>analyzing the brain activity of mice with Parkinson's disease and
>> suddenly
>>>>it reminded me of some research I'd done in the epilepsy field a decade
>>>>earlier. The ideas began to flow from there."
>>>>
>>>>The rhythmic brain activity in the animals with Parkinson's disease
>>>>resembled the mild, continuous, low-frequency seizures that are seen in
>>>>those with epilepsy. One effective therapy for treating epilepsy inv
>> olves
>>>>stimulating the peripheral nerves, which facilitate communication
>> between
>>>>the spinal cord and the body. Researchers took that concept and
>> developed
>>>>a modified approach for a Parkinson's disease model.
>>>>
>>>>Nicolelis says that the low frequency seizures, or oscillations, seen
>>>>in
>>>>the animal model of Parkinson's disease have been observed in humans
>> with
>>>>the condition. Stimulating the dorsal column of the spinal cord reduces
>>>>these oscillations, which researchers believe creates the ability to
>>>>produce motor function.
>>>>
>>>>In a healthy body, neurons fire at varying rates as information is
>>>>transmitted between the brain and the body to initiate normal movement.
>>>>This process breaks down in someone with Parkinson's disease.
>>>>
>>>>"Our device works as an interface with the brain to produce a neural
>> state
>>>>permissive for locomotion, facilitating immediate and dramatic recovery
>> of
>>>>movement," says Per Petersson, co-author of the study. "Following
>>>>stimulation, the neurons desynchronize, similar to the firing pattern
>> that
>>>>you would see when a healthy mouse is continuously moving."
>>>>
>>>>Nicolelis says that if the device is proven safe and effective through
>>>>further research, he imagines it mirroring similar spinal cord
>> stimulator
>>>>technology currently used to treat chronic pain. Small leads are
>> implanted
>>>>over the spinal cord and then connected to a portable generator, a
>>>>small
>>>>device capable of producing mild electrical currents. During the trial
>>>>period, the generator is external, while for permanent treatment it
>> would
>>>>be implanted below the skin.
>>>>
>>>>"If we can demonstrate that the device is safe and effective over the
>> long
>>>>term in primates and then humans, virtually every patient could be
>>>>eligible for this treatment in the near future," Nicolelis said.
>>>>
>>>>The Duke team is collaborating with neuroscientists at the Edmond and
>> Lily
>>>>Safra International Institute of Neuroscience in Natal, Brazil, to test
>>>>the new procedure in primate models of Parkinson's disease prior to
>>>>initiating clinical studies. Neuroscientists from the Brain and Mind
>>>>Institute at the Swiss Institute of Technology (EPFL), in Lausanne,
>>>>Switzerland, will also participate in this international research
>>>>effort
>>>>to translate these new findings into clinical practice.
>>>>
>>>>Study co-authors include William Siesser and Marc Caron.
>>>>
>>>>Funding for this research was provided by grants from the National
>>>>Institutes of Neurological Disorders and Stroke (NINDS), International
>>>>Neuroscience Network Foundation (INNF) and the Anne W. Deane Endowed
>>>>Chair.
>>>>
>>>>----------
>>>>Adapted from materials provided by Duke University Medical Center.
>>>>Email or share this story:
>>>>Need to cite this story in your essay, paper, or report? Use one of the
>>>>following formats:
>>>>APA
>>>>
>>>>MLA
>>>>Duke University Medical Center (2009, March 21). Novel Spinal Cord
>>>>Stimulator Sparks Hope For Parkinson's Disease Treatment
>>>
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August 2003, Week 5 August 2003, Week 4 August 2003, Week 3 August 2003, Week 2 August 2003, Week 1 July 2003, Week 5 July 2003, Week 4 July 2003, Week 3 July 2003, Week 2 July 2003, Week 1 June 2003, Week 5 June 2003, Week 4 June 2003, Week 3 June 2003, Week 2 June 2003, Week 1 May 2003, Week 5 May 2003, Week 4 May 2003, Week 3 May 2003, Week 2 May 2003, Week 1 April 2003, Week 5 April 2003, Week 4 April 2003, Week 3 April 2003, Week 2 April 2003, Week 1 March 2003, Week 5 March 2003, Week 4 March 2003, Week 3 March 2003, Week 2 March 2003, Week 1 February 2003, Week 4 February 2003, Week 3 February 2003, Week 2 February 2003, Week 1 January 2003, Week 5 January 2003, Week 4 January 2003, Week 3 January 2003, Week 2 January 2003, Week 1 December 2002, Week 5 December 2002, Week 4 December 2002, Week 3 December 2002, Week 2 December 2002, Week 1 November 2002, Week 5 November 2002, Week 4 November 2002, Week 3 November 2002, Week 2 November 2002, Week 1 October 2002, Week 5 October 2002, Week 4 October 2002, Week 3 October 2002, Week 2 October 2002, Week 1 September 2002, Week 5 September 2002, Week 4 September 2002, Week 3 September 2002, Week 2 September 2002, Week 1 August 2002, Week 5 August 2002, Week 4 August 2002, Week 3 August 2002, Week 2 August 2002, Week 1 July 2002, Week 5 July 2002, Week 4 July 2002, Week 3 July 2002, Week 2 July 2002, Week 1 June 2002, Week 5 June 2002, Week 4 June 2002, Week 3 June 2002, Week 2 June 2002, Week 1 May 2002, Week 5 May 2002, Week 4 May 2002, Week 3 May 2002, Week 2 May 2002, Week 1 April 2002, Week 5 April 2002, Week 4 April 2002, Week 3 April 2002, Week 2 April 2002, Week 1 March 2002, Week 5 March 2002, Week 4 March 2002, Week 3 March 2002, Week 2 March 2002, Week 1 February 2002, Week 4 February 2002, Week 3 February 2002, Week 2 February 2002, Week 1 January 2002, Week 5 January 2002, Week 4 January 2002, Week 3 January 2002, Week 2 January 2002, Week 1 December 2001, Week 5 December 2001, Week 4 December 2001, Week 3 December 2001, Week 2 December 2001, Week 1 November 2001, Week 5 November 2001, Week 4 November 2001, Week 3 November 2001, Week 2 November 2001, Week 1 October 2001, Week 5 October 2001, Week 4 October 2001, Week 3 October 2001, Week 2 October 2001, Week 1 September 2001, Week 5 September 2001, Week 4 September 2001, Week 3 September 2001, Week 2 September 2001, Week 1 August 2001, Week 5 August 2001, Week 4 August 2001, Week 3 August 2001, Week 2 August 2001, Week 1 July 2001, Week 5 July 2001, Week 4 July 2001, Week 3 July 2001, Week 2 July 2001, Week 1 June 2001, Week 5 June 2001, Week 4 June 2001, Week 3 June 2001, Week 2 June 2001, Week 1 May 2001, Week 5 May 2001, Week 4 May 2001, Week 3 May 2001, Week 2 May 2001, Week 1 April 2001, Week 5 April 2001, Week 4 April 2001, Week 3 April 2001, Week 2 April 2001, Week 1 March 2001, Week 5 March 2001, Week 4 March 2001, Week 3 March 2001, Week 2 March 2001, Week 1 February 2001, Week 4 February 2001, Week 3 February 2001, Week 2 February 2001, Week 1 January 2001, Week 5 January 2001, Week 4 January 2001, Week 3 January 2001, Week 2 January 2001, Week 1 December 2000, Week 5 December 2000, Week 4 December 2000, Week 3 December 2000, Week 2 December 2000, Week 1 November 2000, Week 5 November 2000, Week 4 November 2000, Week 3 November 2000, Week 2 November 2000, Week 1 October 2000, Week 5 October 2000, Week 4 October 2000, Week 3 October 2000, Week 2 October 2000, Week 1 September 2000, Week 5 September 2000, Week 4 September 2000, Week 3 September 2000, Week 2 September 2000, Week 1 August 2000, Week 5 August 2000, Week 4 August 2000, Week 3 August 2000, Week 2 August 2000, Week 1 July 2000, Week 5 July 2000, Week 4 July 2000, Week 3 July 2000, Week 2 July 2000, Week 1 June 2000, Week 5 June 2000, Week 4 June 2000, Week 3 June 2000, Week 2 June 2000, Week 1 May 2000, Week 5 May 2000, Week 4 May 2000, Week 3 May 2000, Week 2 May 2000, Week 1 April 2000, Week 5 April 2000, Week 4 April 2000, Week 3 April 2000, Week 2 April 2000, Week 1 March 2000, Week 5 March 2000, Week 4 March 2000, Week 3 March 2000, Week 2 March 2000, Week 1 February 2000, Week 5 February 2000, Week 4 February 2000, Week 3 February 2000, Week 2 February 2000, Week 1 January 2000, Week 5 January 2000, Week 4 January 2000, Week 3 January 2000, Week 2 January 2000, Week 1 December 1999, Week 5 December 1999, Week 4 December 1999, Week 3 December 1999, Week 2 December 1999, Week 1 November 1999, Week 5 November 1999, Week 4 November 1999, Week 3 November 1999, Week 2 November 1999, Week 1 October 1999, Week 5 October 1999, Week 4 October 1999, Week 3 October 1999, Week 2 October 1999, Week 1 September 1999, Week 5 September 1999, Week 4 September 1999, Week 3 September 1999, Week 2 September 1999, Week 1 August 1999, Week 5 August 1999, Week 4 August 1999, Week 3 August 1999, Week 2 August 1999, Week 1 July 1999, Week 5 July 1999, Week 4 July 1999, Week 3 July 1999, Week 2 July 1999, Week 1 June 1999, Week 5 June 1999, Week 4 June 1999, Week 3 June 1999, Week 2 June 1999, Week 1 May 1999, Week 5 May 1999, Week 4 May 1999, Week 3 May 1999, Week 2 May 1999, Week 1 April 1999, Week 5 April 1999, Week 4 April 1999, Week 3 April 1999, Week 2 April 1999, Week 1 March 1999, Week 5 March 1999, Week 4 March 1999, Week 3 March 1999, Week 2 March 1999, Week 1 February 1999, Week 4 February 1999, Week 3 February 1999, Week 2 February 1999, Week 1 January 1999, Week 5 January 1999, Week 4 January 1999, Week 3 January 1999, Week 2 January 1999, Week 1 December 1998, Week 5 December 1998, Week 4 December 1998, Week 3 December 1998, Week 2 December 1998, Week 1 November 1998, Week 5 November 1998, Week 4 November 1998, Week 3 November 1998, Week 2 November 1998, Week 1 October 1998, Week 5 October 1998, Week 4 October 1998, Week 3 October 1998, Week 2 October 1998, Week 1 September 1998, Week 5 September 1998, Week 4 September 1998, Week 3 September 1998, Week 2 September 1998, Week 1 August 1998, Week 5 August 1998, Week 4 August 1998, Week 3 August 1998, Week 2 August 1998, Week 1 July 1998, Week 5 July 1998, Week 4 July 1998, Week 3 July 1998, Week 2 July 1998, Week 1 June 1998, Week 5 June 1998, Week 4 June 1998, Week 3 June 1998, Week 2 June 1998, Week 1 May 1998, Week 5 May 1998, Week 4 May 1998, Week 3 May 1998, Week 2 May 1998, Week 1 April 1998, Week 5 April 1998, Week 4 April 1998, Week 3 April 1998, Week 2 April 1998, Week 1 March 1998, Week 5 March 1998, Week 4 March 1998, Week 3 March 1998, Week 2 March 1998, Week 1 February 1998, Week 5 February 1998, Week 4 February 1998, Week 3 February 1998, Week 2 February 1998, Week 1 January 1998, Week 5 January 1998, Week 4 January 1998, Week 3 January 1998, Week 2 January 1998, Week 1 December 1997, Week 5 December 1997, Week 4 December 1997, Week 3 December 1997, Week 2 December 1997, Week 1 November 1997, Week 5 November 1997, Week 4 November 1997, Week 3 November 1997, Week 2 November 1997, Week 1 October 1997, Week 5 October 1997, Week 4 October 1997, Week 3 October 1997, Week 2 October 1997, Week 1 September 1997, Week 5 September 1997, Week 4 September 1997, Week 3 September 1997, Week 2 September 1997, Week 1 August 1997, Week 5 August 1997, Week 4 August 1997, Week 3 August 1997, Week 2 August 1997, Week 1 July 1997, Week 5 July 1997, Week 4 July 1997, Week 3 July 1997, Week 2 July 1997, Week 1 June 1997, Week 5 June 1997, Week 4 June 1997, Week 3 June 1997, Week 2 June 1997, Week 1 May 1997, Week 5 May 1997, Week 4 May 1997, Week 3 May 1997, Week 2 May 1997, Week 1 April 1997, Week 5 April 1997, Week 4 April 1997, Week 3 April 1997, Week 2 April 1997, Week 1 March 1997, Week 5 March 1997, Week 4 March 1997, Week 3 March 1997, Week 2 March 1997, Week 1 February 1997, Week 5 February 1997, Week 4 February 1997, Week 3 February 1997, Week 2 February 1997, Week 1 January 1997, Week 5 January 1997, Week 4 January 1997, Week 3 January 1997, Week 2 January 1997, Week 1 December 1996, Week 5 December 1996, Week 4 December 1996, Week 3 December 1996, Week 2 December 1996, Week 1 November 1996, Week 5 November 1996, Week 4 November 1996, Week 3 November 1996, Week 2 November 1996, Week 1 October 1996, Week 5 October 1996, Week 4 October 1996, Week 3 October 1996, Week 2 October 1996, Week 1 September 1996, Week 5 September 1996, Week 4 September 1996, Week 3 September 1996, Week 2 September 1996, Week 1 August 1996, Week 5 August 1996, Week 4 August 1996, Week 3 August 1996, Week 2 August 1996, Week 1 July 1996, Week 5 July 1996, Week 4 July 1996, Week 3 July 1996, Week 2 July 1996, Week 1 June 1996, Week 5 June 1996, Week 4 June 1996, Week 3 June 1996, Week 2 June 1996, Week 1 May 1996, Week 5 May 1996, Week 4 May 1996, Week 3 May 1996, Week 2 May 1996, Week 1 April 1996, Week 5 April 1996, Week 4 April 1996, Week 3 April 1996, Week 2 April 1996, Week 1 March 1996, Week 5 March 1996, Week 4 March 1996, Week 3 March 1996, Week 2 March 1996, Week 1 February 1996, Week 5 February 1996, Week 4 February 1996, Week 3 February 1996, Week 2 February 1996, Week 1 January 1996, Week 5 January 1996, Week 4 January 1996, Week 3 January 1996, Week 2 January 1996, Week 1 December 1995, Week 5 December 1995, Week 4 December 1995, Week 3 December 1995, Week 2 December 1995, Week 1 November 1995, Week 5 November 1995, Week 4 November 1995, Week 3 November 1995, Week 2 November 1995, Week 1 October 1995, Week 5 October 1995, Week 4 October 1995, Week 3 October 1995, Week 2 October 1995, Week 1 September 1995, Week 5 September 1995, Week 4 September 1995, Week 3 September 1995, Week 2 September 1995, Week 1 August 1995, Week 5 August 1995, Week 4 August 1995, Week 3 August 1995, Week 2 August 1995, Week 1 July 1995, Week 5 July 1995, Week 4 July 1995, Week 3 July 1995, Week 2 July 1995, Week 1 June 1995, Week 5 June 1995, Week 4 June 1995, Week 3 June 1995, Week 2 June 1995, Week 1 May 1995, Week 5 May 1995, Week 4 May 1995, Week 3 May 1995, Week 2 May 1995, Week 1 April 1995, Week 5 April 1995, Week 4 April 1995, Week 3 April 1995, Week 2 April 1995, Week 1 March 1995, Week 5 March 1995, Week 4 March 1995, Week 3 March 1995, Week 2 March 1995, Week 1 February 1995, Week 4 February 1995, Week 3 February 1995, Week 2 February 1995, Week 1 January 1995, Week 5 January 1995, Week 4 January 1995, Week 3 January 1995, Week 2 January 1995, Week 1 December 1994, Week 5 December 1994, Week 4 December 1994, Week 3 December 1994, Week 2 December 1994, Week 1 November 1994, Week 5 November 1994, Week 4 November 1994, Week 3 November 1994, Week 2 November 1994, Week 1 October 1994, Week 5 October 1994, Week 4 October 1994, Week 3 October 1994, Week 2 October 1994, Week 1 September 1994, Week 5 September 1994, Week 4 September 1994, Week 3 September 1994, Week 2 September 1994, Week 1 August 1994, Week 5 August 1994, Week 4 August 1994, Week 3 August 1994, Week 2 August 1994, Week 1 July 1994, Week 5 July 1994, Week 4 July 1994, Week 3 July 1994, Week 2 July 1994, Week 1 June 1994, Week 5 June 1994, Week 4 June 1994, Week 3 June 1994, Week 2 June 1994, Week 1 May 1994, Week 5 May 1994, Week 4 May 1994, Week 3 May 1994, Week 2 May 1994, Week 1 April 1994, Week 5 April 1994, Week 4 April 1994, Week 3 April 1994, Week 2 April 1994, Week 1 March 1994, Week 5 March 1994, Week 4 March 1994, Week 3 March 1994, Week 2 March 1994, Week 1 February 1994, Week 4 February 1994, Week 3 February 1994, Week 2 February 1994, Week 1 February 1994 January 1994 December 1993 November 1993
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