I remeber budipine being discussed on this list years ago. There must be 
something in the archives
maryse


> Just found this...more serious fx, though if none of these conditions
> pertains, it seems to me that budipine still might be a good choice and
> could add one more stop on the way to DBS.
>
> Kathleen
>
>
> http://apps.who.int/medicinedocs/fr/d/Jh1466e/2.6.html#Jh1466e.2.6
>
> Budipine - revised data sheet: cardiac adverse reactions
>
> *Germany.* The manufacturer of the antiparkinsonian agent, budipine
> (Parkinsan®: Byk Gulden Lomberg and Lundbeck) has revised the product
> information for this product to extend the contraindications to include
> patients with cardiomyopathy, myocarditis and AV Block II and III as well 
> as
> patients with a history of ventricular arrhythmia, especially tachycardia
> (torsade de pointes). In addition an electrocardiogram should be performed
> before the start of therapy, then again one to three weeks afterwards and 
> on
> increase of the dosage. Patients with a QTc value over 420 ms or 
> discernible
> U-waves, or with an increase in QTc of over 60 ms and accordingly a QTc 
> time
> of over 480 ms and discernible U-waves when taking budipine are excluded
> from treatment.
>
> As regards risk factors for electrolyte imbalance, e.g. diuretic 
> medication,
> frequent vomiting and/or diarrhoea, use of insulin in an emergency, kidney
> disease or anorexia, laboratory tests should be performed, especially for
> potassium and magnesium. As soon as symptoms such as palpitations, 
> dizziness
> or syncope appear, budipine must be withdrawn and, if necessary, the 
> patient
> examined for QT-prolongation.
>
> This action was taken in the context of the ongoing review of marketed
> products carried out by the Federal Institute for Drugs and Medical 
> Devices
> which found that the incidence of cardiac adverse reactions was not
> adequately reflected in the product information.
>
> *References: Deutsche Apotheker Zeitung 140(41): 4662 (2000).*
>
>
>
> [image: Afficher le
> document]<http://apps.who.int/medicinedocs/fr/d/Jh1466e/4.1.html>Safety
> of Herbal medicines - Discussion at the 23rd meeting of national drug
> monitoring centres, Tunisia, November
> 2000<http://apps.who.int/medicinedocs/fr/d/Jh1466e/4.1.html> [image:
> Afficher le 
> document]<http://apps.who.int/medicinedocs/fr/d/Jh1466e/4.2.html>Effects
> of paracetamol pack size restriction on
> overdose<http://apps.who.int/medicinedocs/fr/d/Jh1466e/4.2.html>
>
>
>
> 2009/10/1 Kathleen Cochran <[log in to unmask]>
>
>> More about the "new" treatment, budipine...new in 1986, that is. Why is
>> this not part of the accepted regimen for tremor dominant PD? Does the 
>> lower
>> case "b" mean that perhaps no one makes much money from it?
>>
>> http://www.springerlink.com/content/q65m76n526027107/
>>
>> Kathleen
>>
>> 2009/10/1 rayilynlee <[log in to unmask]>
>>
>> Rayilyn Brown
>>> Director AZNPF
>>> Arizona Chapter National Parkinson Foundation
>>> [log in to unmask]
>>>
>>>
>>> From: Diane Wyshak
>>> Sent: Wednesday, September 30, 2009 11:31 AM
>>> To: ray ; chew Nee Kong
>>> Subject: Good and bad news for Tremor dominant wpd - NeuroTalk 
>>> Communities
>>>
>>>
>>>
>>> http://neurotalk.psychcentral.com/showthread.php?t=104263
>>>
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>>
>>
>
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