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English translation please :-)
defn of IPD and PN would help......
Ken
----- Original Message -----
From: "mschild" <[log in to unmask]>
To: <[log in to unmask]>
Sent: Wednesday, August 04, 2010 1:19 AM
Subject: Neuropathy in Parkinson’s Disease May Be Related to L-DopaExposure
> Posted: 07/26/2010; AccessMedicine from McGraw-Hill © 2010 The McGraw-Hill
> Companies
>
>
>
>
>
> Idiopathic Parkinson’s disease (IPD) is a central nervous system disorder
> affecting the basal ganglia that is caused by death of dopamine-producing
> cells
> in the substantia nigra. Although IPD is thought classically to spare the
> peripheral nervous system, an association between peripheral neuropathy
> (PN)
> and IPD has been demonstrated in some of the rare genetic forms of
> Parkinson’s
> disease. A recent study (Toth et al, 2010) aimed to examine the
> relationship
> between the more common form of IPD and PN.
>
> The authors conducted a prospective cohort study by randomly selecting
> patients from a database of IPD patients at a tertiary center in Canada.
> Patients as well as age- and gender-matched controls underwent detailed
> clinical assessment, neurophysiologic testing using nerve conduction
> studies,
> and a thorough laboratory assessment for causes of neuropathy. Patients
> who
> could not tolerate these tests or who had known risk factors for PN such
> as
> diabetes were excluded.
>
> A total of 58 IPD patients were included in the study. Symptoms of PN were
> present in 43% of the IPD patients but in only 5% of the control subjects.
> There were no significant differences in risk factors for PN between the
> IPD and
> control patients. Three IPD patients were excluded because two
> neurologists,
> one blinded to the diagnosis of IPD, disagreed as to the diagnosis of PN.
> Of
> the remaining 55 IPD patients, 32 (58%) were diagnosed with PN using a
> standard electrophysiologic and clinical assessment; 24 of these had
> symptomatic PN. Only 5 of the 58 controls (9%) were diagnosed with PN.
> Duration of IPD before assessment was similar in the IPD with and without
> PN
> groups, although severity of IPD was greater in the IPD with PN patients.
>
> To discern the etiology of PN in IPD patients, the authors examined a
> number
> of known causes of neuropathy, most of which were unrevealing. Although
> similar cobalamin levels were found in the IPD groups with and without PN,
> fasting homocysteine and methylmalonic acid (MMA) levels were
> significantly
> higher in the IPD group with PN.
>
> The odds ratio for exposure to L-dopa in the IPD patients with PN was 12.4
> (95% confidence interval, 1.4–109.1). There were no differences between
> the
> groups in the use of other PD drugs, including dopamine agonists, COMT
> inhibitors, anticholinergic agents, and amantadine. Cumulative L-dopa
> exposure
> was associated not only with PN, but also with elevated fasting MMA levels
> across all IPD patients in the study. L-dopa exposure was also associated
> with
> PN severity in the IPD patients with PN.
>
> This intriguing study demonstrates a somewhat unexpectedly high prevalence
> of
> PN in IPD patients and cites an association with elevated MMA levels,
> perhaps
> mediated by exposure to L-dopa. L-dopa may indeed interact with
> methylation
> pathways involved in folate metabolism, providing a mechanism for MMA
> elevation. Although causation is not proven here, if verified, this study
> may
> change the way we care for patients with IPD. PN in IPD could
> substantially
> contribute to gait disturbance and disability in some patients with IPD,
> and
> prevention of PN would be an important advance. Exposure to L-dopa is
> inevitable in most IPD patients at some point during their course, but
> perhaps
> we should be measuring MMA levels in these patients and treating with
> cobalamin supplementation to reduce MMA levels and prevent neuropathy.
> Further
> studies, including treatment trials, seem warranted.
>
> ----------------------------------------------------------------------
> To sign-off Parkinsn send a message to:
> mailto:[log in to unmask]
> In the body of the message put: signoff parkinsn
>
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Week 4 October 1997, Week 3 October 1997, Week 2 October 1997, Week 1 September 1997, Week 5 September 1997, Week 4 September 1997, Week 3 September 1997, Week 2 September 1997, Week 1 August 1997, Week 5 August 1997, Week 4 August 1997, Week 3 August 1997, Week 2 August 1997, Week 1 July 1997, Week 5 July 1997, Week 4 July 1997, Week 3 July 1997, Week 2 July 1997, Week 1 June 1997, Week 5 June 1997, Week 4 June 1997, Week 3 June 1997, Week 2 June 1997, Week 1 May 1997, Week 5 May 1997, Week 4 May 1997, Week 3 May 1997, Week 2 May 1997, Week 1 April 1997, Week 5 April 1997, Week 4 April 1997, Week 3 April 1997, Week 2 April 1997, Week 1 March 1997, Week 5 March 1997, Week 4 March 1997, Week 3 March 1997, Week 2 March 1997, Week 1 February 1997, Week 5 February 1997, Week 4 February 1997, Week 3 February 1997, Week 2 February 1997, Week 1 January 1997, Week 5 January 1997, Week 4 January 1997, Week 3 January 1997, Week 2 January 1997, Week 1 December 1996, Week 5 December 1996, Week 4 December 1996, Week 3 December 1996, Week 2 December 1996, Week 1 November 1996, Week 5 November 1996, Week 4 November 1996, Week 3 November 1996, Week 2 November 1996, Week 1 October 1996, Week 5 October 1996, Week 4 October 1996, Week 3 October 1996, Week 2 October 1996, Week 1 September 1996, Week 5 September 1996, Week 4 September 1996, Week 3 September 1996, Week 2 September 1996, Week 1 August 1996, Week 5 August 1996, Week 4 August 1996, Week 3 August 1996, Week 2 August 1996, Week 1 July 1996, Week 5 July 1996, Week 4 July 1996, Week 3 July 1996, Week 2 July 1996, Week 1 June 1996, Week 5 June 1996, Week 4 June 1996, Week 3 June 1996, Week 2 June 1996, Week 1 May 1996, Week 5 May 1996, Week 4 May 1996, Week 3 May 1996, Week 2 May 1996, Week 1 April 1996, Week 5 April 1996, Week 4 April 1996, Week 3 April 1996, Week 2 April 1996, Week 1 March 1996, Week 5 March 1996, Week 4 March 1996, Week 3 March 1996, Week 2 March 1996, Week 1 February 1996, Week 5 February 1996, Week 4 February 1996, Week 3 February 1996, Week 2 February 1996, Week 1 January 1996, Week 5 January 1996, Week 4 January 1996, Week 3 January 1996, Week 2 January 1996, Week 1 December 1995, Week 5 December 1995, Week 4 December 1995, Week 3 December 1995, Week 2 December 1995, Week 1 November 1995, Week 5 November 1995, Week 4 November 1995, Week 3 November 1995, Week 2 November 1995, Week 1 October 1995, Week 5 October 1995, Week 4 October 1995, Week 3 October 1995, Week 2 October 1995, Week 1 September 1995, Week 5 September 1995, Week 4 September 1995, Week 3 September 1995, Week 2 September 1995, Week 1 August 1995, Week 5 August 1995, Week 4 August 1995, Week 3 August 1995, Week 2 August 1995, Week 1 July 1995, Week 5 July 1995, Week 4 July 1995, Week 3 July 1995, Week 2 July 1995, Week 1 June 1995, Week 5 June 1995, Week 4 June 1995, Week 3 June 1995, Week 2 June 1995, Week 1 May 1995, Week 5 May 1995, Week 4 May 1995, Week 3 May 1995, Week 2 May 1995, Week 1 April 1995, Week 5 April 1995, Week 4 April 1995, Week 3 April 1995, Week 2 April 1995, Week 1 March 1995, Week 5 March 1995, Week 4 March 1995, Week 3 March 1995, Week 2 March 1995, Week 1 February 1995, Week 4 February 1995, Week 3 February 1995, Week 2 February 1995, Week 1 January 1995, Week 5 January 1995, Week 4 January 1995, Week 3 January 1995, Week 2 January 1995, Week 1 December 1994, Week 5 December 1994, Week 4 December 1994, Week 3 December 1994, Week 2 December 1994, Week 1 November 1994, Week 5 November 1994, Week 4 November 1994, Week 3 November 1994, Week 2 November 1994, Week 1 October 1994, Week 5 October 1994, Week 4 October 1994, Week 3 October 1994, Week 2 October 1994, Week 1 September 1994, Week 5 September 1994, Week 4 September 1994, Week 3 September 1994, Week 2 September 1994, Week 1 August 1994, Week 5 August 1994, Week 4 August 1994, Week 3 August 1994, Week 2 August 1994, Week 1 July 1994, Week 5 July 1994, Week 4 July 1994, Week 3 July 1994, Week 2 July 1994, Week 1 June 1994, Week 5 June 1994, Week 4 June 1994, Week 3 June 1994, Week 2 June 1994, Week 1 May 1994, Week 5 May 1994, Week 4 May 1994, Week 3 May 1994, Week 2 May 1994, Week 1 April 1994, Week 5 April 1994, Week 4 April 1994, Week 3 April 1994, Week 2 April 1994, Week 1 March 1994, Week 5 March 1994, Week 4 March 1994, Week 3 March 1994, Week 2 March 1994, Week 1 February 1994, Week 4 February 1994, Week 3 February 1994, Week 2 February 1994, Week 1 February 1994 January 1994 December 1993 November 1993
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