yup and thanks



-----Original Message-----
From: A Phillips <[log in to unmask]>
To: PARKINSN <[log in to unmask]>
Sent: Tue, Apr 10, 2012 8:03 am
Subject: Re: Curcumin


yup
 

> -----Original Message----- 
> From: Meg Duggan
> Sent: Thursday, March 29, 2012 2:44 PM
> To: [log in to unmask]
> Subject: Curcumin
> 
> Here are the beginnings of what I'm learning about curcumin... improved 
> version will be in my newsletter next week, along with antioxidants and a 
> bit more on proteins.... say "yup" if want me to add you to my list!
> 
> Curcumin
> Curcumin is the active-inflammatory compound found in the Indian spice 
> turmeric, which is a member of the ginger family. A study published just 
> last week in the Journal of Biological Chemistry found that curcumin is 
> proving to be effective at preventing protein clumping in Parkinson’s 
> disease. (see sidebar.) Research published in the journal PLoS also showed 
> that curcumin molecules target the amyloid fibrils associated with the 
> unnatural progression of the protein-like plaque tangles that are 
> characteristic in Alzheimer’s.
> Previous research into curcumin has shown that it has a positive effect on 
> neurogenesis in the hippocampus and increases the levels of brain-derived 
> neurotrophic factor (BDNF) in rats. Further research into a curcumin 
> derivative found that it improves memory and was broadly neuroprotective, 
> stimulating BDNF in vitro and in vivo ( within the glass and within the 
> living.)
> So why aren’t all Parkinson patients sprinkling curry powder on everything 
> and ingesting curcumin caplets? One reason is that curcumin is poorly 
> bioavailable. Bioavailability is defined as the degree to which or rate at 
> which a drug or other substance is absorbed or becomes available at the site 
> of physiological activity after administration. Basically, curcumin is not 
> well absorbed, is rapidly metabolized and is quickly eliminated.
> I found a pretty clear explanation of what happens to curcumin once we 
> swallow it. The author posted anonymously on the American Cancer Society 
> site. I paraphrase the post here, with thanks to the author!
> “The starting point to understanding the central issue of low 
> bioavailability is to realize that curcumin in insolubale in water at pH of 
> 7 and below. Therefore, in the stomach, where the curcumin first encounters 
> body fluids, it remains insoluble because the stomach fluids are acidic. 
> Once the stomach contents enter the small intestine they are changed to 
> alkaline pH by the bile and other digestive fluids that are injected there. 
> Curcumin thus dissolves in the small intestine. From the small intestine, 
> the curcumin might be dissolved into the capillaries of the hepatic venous 
> system that serves the stomach and large and small intestines. However, the 
> curcumin in the small intestine exists as small crystals or clumps of 
> crystals that cannot pass through the tiny pores in the capillary walls. 
> The remedy is to be sure that the curcumin is in a solution that allows it 
> to circulate to the rest of the body to organs that might use is 
> beneficially. “
> Curcumin dissolved or cooked in oil has increased bioavailbility, and oil 
> based capsules are available on the internet in strengths from 450 to 100 
> milligrams. However, a search of the blogosphere turned up many instances 
> of people who prefer to dissolve their own turmeric, mostly to avoid the 
> very high numbers of capsules that must be ingested and to save money. 
> Curcumin is more bioavailable when heated, though do not boil it.
> Here are a few “recipies” I found:
> Dissolve a teaspoon of curcumin powder in very warm milk and add omega 
> 3-6-9 lemon flavor oil. Option – add coconut oil instead of the lemon oil. 
> Rated “very palatable.”
> Dissolve curcumin in a teaspoon or two of organic flax seed oil. Then add 
> about 1/3 cup of organic fruit yogurt and stir. Add ¼ to ½ cup of frozen 
> raspberries or other frozen fruit and stir into a kind of frozen yogurt. 
> Rated “doesn’t taste wonderful but is palatable due to the fruit flavor and 
> the cold.”
> Melt chocolate with butter and milk, stir in one full teaspoon of curcumin. 
> Rated “ very palatable.”
> One teaspoon of curcumin equals 4 grams. Clinical studies in humans have 
> found that doses of curcumin from 2 – 12 grams are shown to have few side 
> effects. Side effects are mostly mild nausea or diarrhea. However, a daily 
> dose of 12 grams has only been studied over a three month period. Recently, 
> curcumin has been found to alter iron metabolism by chelating iron and 
> suppressing the protein hepcidin, potentially causing iron deficiency in 
> susuceptible patients.
> 
> 
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