I know what you mean !
I do a lot of my computer use lying on the floor so I can steady my forearm on the floor.
That does of course produce the problem of getting upright again.  
Is a tablet easier ?
 
> Date: Thu, 30 Jan 2014 11:07:02 -0700
> From: [log in to unmask]
> Subject: mouse speed
> To: [log in to unmask]
> 
> Amanda, we've already adjusted for mouse speed.  Its  me not the mouse.  my 
> "fine  motor skills" are nonexistent.
> 
> -----Original Message----- 
> From: A Phillips
> Sent: Wednesday, January 29, 2014 4:21 PM
> To: [log in to unmask]
> Subject: Re: ProSavin gene therapy
> 
> It  should be possible if fiddly to adjust the way the mouse reacts, eg make 
> it less or more movement-sensitive.
> You might also find a bigger mouse easier (or even a smaller one if like me 
> you have small hands).
> 
> 
> > Date: Mon, 27 Jan 2014 09:16:47 -0500
> > From: [log in to unmask]
> > Subject: Re: ProSavin gene therapy
> > To: [log in to unmask]
> >
> > You are doing just fine posting all sorts of important information for 
> > PWP.
> > Good for you, Ray.  We all depend upon you so just keep on keeping on. 
> > :-)
> > ---------
> > Mary Ann
> > ----- Original Message ----- 
> > From: "Rayilyn Brown" <[log in to unmask]>
> > To: <[log in to unmask]>
> > Sent: Sunday, January 26, 2014 7:10 PM
> > Subject: Re: ProSavin gene therapy
> >
> >
> > > Mary  Ann
> > >
> > > Great you have  such close family!!  Medical clinic sounds interesting.
> > >
> > > I haven't down such a good job of posting since my research buddy, 
> > > Diane,
> > > died over two years ago.   also  my  computer does some strange things
> > > when I move the  mouse and "click".  Its harder to cut and paste now, 
> > > but
> > > I hope I won't  miss real news.
> > >
> > > -----Original Message----- 
> > > From: Mary Ann Ryan
> > > Sent: Friday, January 24, 2014 7:46 AM
> > > To: [log in to unmask]
> > > Subject: Re: ProSavin gene therapy
> > >
> > > Ray, life is good here.  Jamie continues to be a part of our lives - my
> > > grandkids sit in his recliner more than in any other furniture in the
> > > house
> > > so I think they feel his sweet presence.  I volunteer once a week at a
> > > homeless shelter  - I run a medical clinic there.  We still have the 
> > > farm
> > > and continue to plant a huge garden every year.  My daughter and her
> > > husband
> > > plus their two kids live with me so I never feel alone.  My son and
> > > daughter-in-law visit frequently.
> > >
> > > It's good to see that you still are active in informing PWP about 
> > > studies
> > > and the need for advocacy.  Thanks for all that you do.
> > > --------
> > > Mary Ann
> > > ----- Original Message ----- 
> > > From: "Rayilyn Brown" <[log in to unmask]>
> > > To: <[log in to unmask]>
> > > Sent: Thursday, January 23, 2014 2:20 PM
> > > Subject: Re: ProSavin gene therapy
> > >
> > >
> > >> you're welcome, Mary Ann.   How are you doing?
> > >>
> > >> -----Original Message----- 
> > >> From: Mary Ann Ryan
> > >> Sent: Wednesday, January 22, 2014 7:31 AM
> > >> To: [log in to unmask]
> > >> Subject: Re: ProSavin gene therapy
> > >>
> > >> Thanks, Ray.  This is great information and I plan on saving it for
> > >> future
> > >> use.  It is frustrating that a miracle therapy is not on the horizon 
> > >> but
> > >> at
> > >> least you got the attention of this doctor so that the PD community can
> > >> be
> > >> better informed.  Thank you so much for your effort.
> > >> -------
> > >> Mary Ann (CG Jamie 68/28 with PD, died 11/20/07)
> > >>
> > >>
> > >>
> > >>> Dear Rayilyn,
> > >>>
> > >>> I perfectly understand your current situation. Although I have been
> > >>> trained as MD, I have never treated patients since I am engaged 100% 
> > >>> in
> > >>> PD research. I am in close contact with the Spanish association of
> > >>> Parkinson's disease, and I strongly feel that one of my obligations is
> > >>> to explain the patients what's going on in PD research. I know that it
> > >>> is fustrating to see that anything new has arrived in the past few
> > >>> years, besides some minor improvements in dopamine-replacement 
> > >>> therapies
> > >>> (if I am right, a phase 2 trial testing an inhaled preparation of
> > >>> levodopa is going to start soon in US). When attending scientific
> > >>> meetings, the overall feeling is that everybody is always moving 
> > >>> around
> > >>> the same topics, without any real new improvement or any real new 
> > >>> ideas
> > >>> to follow. In this regard, gene-based therapies such as ProSavin at
> > >>> least represent something different. I cannot anticipate how long will
> > >>> it take to see these new arrivals fully available in the market as a
> > >>> therapeutic tool. Nevertheless, I still thinking that approaches this
> > >>> kind at least represent something different, and I am sure that this 
> > >>> is
> > >>> a right step in the right direction. In the past two years my group 
> > >>> has
> > >>> received some EU funding to start testing different approaches of gene
> > >>> therapy for manipulating basal ganglia circuits. We are using
> > >>> MPTP-treated monkeys since these represent the best animal model
> > >>> available so far, and working with monkeys speeds up the time required
> > >>> to start testing new tools in humans suffering from PD. I can give you
> > >>> my word that we are working very hard trying to generate the expected
> > >>> results asap. We have just started several experiments, all very risky
> > >>> approaches, and therefore I cannot anticipate any final result.
> > >>> Nevertheless, you can be sure that the situation of PD patients always
> > >>> is very well represented in my mind at all times.
> > >>>
> > >>> I know that it is not easy to be optimistic in the current scenario.
> > >>> However, my personal feeling is that testing some new research avenues
> > >>> has just been started. There is too much pressure to go traslational,
> > >>> and to start testing new approaches in patients asap. This pressure
> > >>> implies that some promising things enter clinical trials too early, 
> > >>> and
> > >>> therefore it is fustrating to see that most of these new therapies
> > >>> failed in clinical trials. Just simply remember the failures of GDNF 
> > >>> and
> > >>> nurturin. These are very good examples of promising things that failed
> > >>> because by the time these get tested in humans, we knew very little
> > >>> about their function. For instance, by the time in which GDNF entered
> > >>> phases 1-2 (the "Kentucky" and "Bristol" trials), we didn't knew too
> > >>> much about the neurobiology of GDNF. Researches we have to deal with
> > >>> this pressure, that's life. However, my feeling is that we cannot
> > >>> generate any solid expectances for PD patients without a clear
> > >>> proof-of-principle. As I have mentioned before, some failures we have
> > >>> seen in the past easily rank within this category of things being 
> > >>> tested
> > >>> too early.
> > >>>
> > >>> According to the published results from ProSavin, this might not be 
> > >>> seen
> > >>> as the way to go. My opinion is just the opposite. Although I will 
> > >>> have
> > >>> been delighted to see a better clinical outcome, the important 
> > >>> argument
> > >>> of ProSavin is that approaches this kind at least opens new vistas in 
> > >>> PD
> > >>> research. I can perfectly understand that you are tired of getting 
> > >>> worse
> > >>> and waiting. I just can tell you that everything that me -and many
> > >>> others- we are currently doing is done bearing in mind at all times 
> > >>> the
> > >>> clinical situation of thousands of PD patients. You are our main
> > >>> motivation, and this is how things should be. Of course I cannot 
> > >>> promise
> > >>> any miracle, just a tireless effort in PD research, every day.
> > >>>
> > >>> All the best and have a nice day, Jose L. Lanciego
> > >>>
> > >>> Rayilyn Brown escribió:
> > >>>> Jose
> > >>>>
> > >>>> I've had PD 18 years, have gotten worse, am 78 years old and fear at
> > >>>> the present pace of research will not live long enough to benefit 
> > >>>> from
> > >>>> any of the 'promising" treatments on the horizon.  I'm tired of 
> > >>>> getting
> > >>>> worse and waiting.  But then I'm anemic, maybe that’s it.
> > >>>>
> > >>>> -----Original Message----- From: José Luis Lanciego
> > >>>> Sent: Tuesday, January 21, 2014 3:06 AM
> > >>>> To: [log in to unmask]
> > >>>> Subject: Re: ProSavin gene therapy
> > >>>>
> > >>>> Dear Rayilyn,
> > >>>>
> > >>>> I guess this is not discouraging at all. Although this is a 
> > >>>> preliminary
> > >>>> study, my feeling is that ProSavin represents a right step in the 
> > >>>> right
> > >>>> direction. A number of gene therapy experiments are currently
> > >>>> undergoing
> > >>>> and we will see what's coming out in the next few years. Indeed, this
> > >>>> approach -and few more under experimental implementation- is 
> > >>>> something
> > >>>> different, e.g., it is not based on dopamine-replacement strategies. 
> > >>>> My
> > >>>> laboratory -as many others- strongly feels that many new arrivals can
> > >>>> be
> > >>>> expected from gene therapy experiments, with the ultimate goal of 
> > >>>> using
> > >>>> gene therapy tools to manipulate basal ganglia circuits. Compared to
> > >>>> cell therapies, gene therapy seems to be a much more feasible and
> > >>>> realistic strategy.
> > >>>>
> > >>>> All the best and have a nice day, Jose L. Lanciego
> > >>>>
> > >>>> Rayilyn Brown escribió:
> > >>>>> discouraging isn't it?
> > >>>>>
> > >>>>> -----Original Message----- From: Nic Marais
> > >>>>> Sent: Saturday, January 18, 2014 12:29 AM
> > >>>>> To: [log in to unmask]
> > >>>>> Subject: Re: ProSavin gene therapy
> > >>>>>
> > >>>>> When you read the Viartis notification, it does not look as positive
> > >>>>> as
> > >>>>> this article...
> > >>>>>
> > >>>>> http://www.viartis.net/parkinsons.disease/news/140113.htm
> > >>>>>
> > >>>>> Nic 61/19
> > >>>>>
> > >>>>>
> > >>>>> On 17 January 2014 21:18, Rayilyn Brown <[log in to unmask]> wrote:
> > >>>>>
> > >>>>>> http://www.domain-b.com/technology/Health_Medicine/20140115_patients.html
> > >>>>>>
> > >>>>>> Ray
> > >>>>>> Rayilyn
> > >>>>>> Past Director AZNPF
> > >>>>>> Arizona Chapter National Parkinson Foundation
> > >>>>>>
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