Part One of a MEDLINE on PD and childhood diseases, influenza, and
possible environmental exposures:
 
------------------------------------------------------------
 
 2/L/6
DIALOG(R)File 154:MEDLINE(R)
(c) format only 1995 Knight-Ridder Info. All rts. reserv.
 
07594964   91113964
  Similarities  of  guamanian ALS/PD to post-encephalitic
parkinsonism/ALS:
possible viral cause.
  Hudson AJ; Rice GP
  Department   of  Clinical  Neurological  Sciences,  University
Hospital,
London, Ontario.
  Can J Neurol Sci (CANADA)   Nov 1990,  17 (4) p427-33,  ISSN 0317-1671
Journal Code: CJ9
  Languages: ENGLISH
  Document type: JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
  JOURNAL ANNOUNCEMENT: 9105
  Subfile:   INDEX MEDICUS
  Guamanian   amyotrophic   lateral  sclerosis  with
parkinsonism-dementia
(ALS/PD)  has  been  the  subject of intensive study since its discovery
in
1947  because of its extraordinarily high incidence in a small ethnic
group
(Chamorros)  whose dietary lack and customs have suggested possible
causes.
As  yet,  these  and  other  suspected causes have eluded proof. Because
of
marked    similarities    between   Guamanian   ALS/PD   and   late
onset
post-encephalitic  (encephalitis  lethargica)  parkinsonism  and  ALS it
is
suggested  that  they  have a common cause. The parkinsonism and ALS in
the
two  disorders  are  clinically  very similar and neuropathological
studies
have  shown  a  very  similar  distribution  of  neurofibrillary tangles
in
neurons.  Some  clinical  differences,  such  as  ocular  features  in
the
post-encephalitic  cases and dementia in Guamanian ALS/PD, can be
explained
by  differences  in  the severity of infection and the interval between
the
encephalitis and onset of sequelae. Although unproven, influenza A
(HswilN1
strain)  has  long  been  suspected as the cause of encephalitis
lethargica
because of simultaneous pandemics of the two diseases in the 1920s.
Because
influenza  A  can  persistently infect cells and has a marked propensity
to
mutate  it  is  an  optimal  candidate  among other RNA viruses for
delayed
nervous system infection as a possible cause of ALS/PD.  (55 Refs.)
  Tags: Human
  Descriptors: *Amyotrophic Lateral Sclerosis--Microbiology--MI;
*Parkinson
Disease,  Postencephalitic--Microbiology--MI;
Dementia--Complications--CO;
Guam
 
 2/L/8
DIALOG(R)File 154:MEDLINE(R)
(c) format only 1995 Knight-Ridder Info. All rts. reserv.
 
07059495   89361495
  Could  Parkinson's  disease follow intra-uterine influenza? A
speculative
hypothesis [letter; comment]
  Singer C; Weiner WJ
  J  Neurol  Neurosurg Psychiatry (ENGLAND)   Jul 1989,  52 (7) p931,
ISSN
0022-3050   Journal Code: JBB
  Comment on  J Neurol Neurosurg Psychiatry 1988 Jun;51(6):753-6
  Languages: ENGLISH
  Document type: COMMENT; LETTER
  JOURNAL ANNOUNCEMENT: 8912
  Subfile:   INDEX MEDICUS
  Tags: Female; Human
  Descriptors:    *Parkinson    Disease,
Postencephalitic--Etiology--ET;
*Prenatal  Exposure  Delayed  Effects;  Diseases  in Twins; Pregnancy;
Risk
Factors
 
 2/L/9
DIALOG(R)File 154:MEDLINE(R)
(c) format only 1995 Knight-Ridder Info. All rts. reserv.
 
07059484   89361484
  Does idiopathic parkinsonism in Aberdeen follow intrauterine
influenza?
  Ebmeier KP; Mutch WJ; Calder SA; Crawford JR; Stewart L; Besson JO
  Department of Mental Health, University of Aberdeen, UK.
  J Neurol Neurosurg Psychiatry (ENGLAND)   Jul 1989,  52 (7) p911-3,
ISSN 0022-3050   Journal Code: JBB
  Languages: ENGLISH
  Document type: JOURNAL ARTICLE
  JOURNAL ANNOUNCEMENT: 8912
  Subfile:   INDEX MEDICUS
  A  study  is presented which fails to replicate a recent report that
peak
years of birth of patients later developing Parkinson's disease are
related
to the influenza pandemics of the period 1890-1930. The years of birth
of a
whole  population cohort of 243 patients suffering from Parkinson's
disease
examined  in  Aberdeen  in 1983 and reexamined in 1986/7 were compared
with
deaths  due  to  influenza  in the City of Aberdeen in the years
1900-1930.
Although  a  significant  peak  of  Parkinson births (compared with the
age
profile  of  the  Aberdeen  population  in  1983)  occurred  in 1902,
there
appeared  to  be  no  systematic  relationship between Parkinson births
and
influenza  deaths. In addition, no season of birth effect could be
detected
in  a  comparison with 232 matched controls. The presence of peaks of
birth
years,   for   whatever   aetiological   reason,   is  of  significance
 to
epidemiological  studies  in that prevalence estimates may be influenced
by
the year of study relative to these mini-cohorts.
  Tags: Female; Human; Support, Non-U.S. Gov't
  Descriptors:    *Parkinson    Disease,
Postencephalitic--Etiology--ET;
*Prenatal Exposure Delayed Effects; Aged; Aged, 80 and over; Cohort
Studies
; Follow-Up Studies; Middle Age; Pregnancy; Risk Factors; Scotland
 
 2/L/10
DIALOG(R)File 154:MEDLINE(R)
(c) format only 1995 Knight-Ridder Info. All rts. reserv.
 
06655091   88300091
  Could  Parkinson's disease follow intra-uterine influenza?: a
speculative
hypothesis [see comments]
  Mattock C; Marmot M; Stern G
  Department of Community Medicine, University College and Middlesex
School
of Medicine, London, UK.
  J Neurol Neurosurg Psychiatry (ENGLAND)   Jun 1988,  51 (6) p753-6,
ISSN 0022-3050   Journal Code: JBB
  Comment in  J Neurol Neurosurg Psychiatry 1989 Jul;52(7):931
  Languages: ENGLISH
  Document type: JOURNAL ARTICLE
  JOURNAL ANNOUNCEMENT: 8811
  Subfile:   INDEX MEDICUS
  Patients  with  idiopathic  Parkinson's  disease  do  not  appear  to
 be
distributed smoothly with respect to year of birth. Individuals born
within
the  years  1892,  1904,  1909,  1918,  1919 and 1929 appear to have had
an
increased  risk of developing idiopathic Parkinson's disease in later
life.
These  years  are  close  to those of the influenza pandemics of the
period
1890-1930.  The  estimated  risk  of  an  individual  developing
idiopathic
Parkinson's   disease  shows  a  significant  correlation  with  the
crude
influenza  mortality  for  the  year of his birth, within the range 1900
to
1930.  It is suggested that intra-uterine influenza may be cytotoxic to
the
developing  foetal substantia nigra, and that an affected individual may
be
born  without  evident  disability  but with limited striatal
neurochemical
reserves  and  a  reduced  nigral cell count. In later life normal
cellular
involution  with ageing or exposure to environmental neurotoxic factors
may
further  erode  these  reserves to a level where the substantia nigra
fails
and idiopathic Parkinson's disease becomes clinically apparent.
  Tags: Female; Human; Male
  Descriptors:  *Disease Outbreaks--Epidemiology--EP;
*Influenza--Mortality
--MO;    *Parkinson   Disease--Mortality--MO;   *Pregnancy
Complications,
Infectious--Mortality--MO;  *Prenatal Exposure Delayed Effects; Aged;
Aged,
80 and over; England; Middle Age; Pregnancy; Risk Factors; Wales
 
 2/L/12
DIALOG(R)File 154:MEDLINE(R)
(c) format only 1995 Knight-Ridder Info. All rts. reserv.
 
06312535   87286535
  Was  a  neurovirulent  influenza  virus  the cause of amyotrophic
lateral
sclerosis and parkinsonism-dementia on Guam?
  Maurizi CP
  Med Hypotheses (ENGLAND)   Jul 1987,  23 (3) p325-6,  ISSN 0306-9877
Journal Code: M0M
  Languages: ENGLISH
  Document type: JOURNAL ARTICLE
  JOURNAL ANNOUNCEMENT: 8711
  Subfile:   INDEX MEDICUS
  Tags: Human
  Descriptors:  *Amyotrophic Lateral Sclerosis--Microbiology--MI;
*Dementia
--Microbiology--MI;     *Orthomyxoviridae--Pathogenicity--PY;
*Parkinson
Disease--Microbiology--MI;    Adolescence;   Adult;   Amyotrophic
Lateral
Sclerosis--Epidemiology--EP;     Child;    Child,    Preschool;
Dementia
--Epidemiology--EP;   Dementia--Etiology--ET;  Guam;  Middle Age;
Parkinson
Disease--Complications--CO;  Parkinson Disease--Epidemiology--EP
 
 2/L/14
DIALOG(R)File 154:MEDLINE(R)
(c) format only 1995 Knight-Ridder Info. All rts. reserv.
 
05746779   86047779
  Measles infection and Parkinson's disease.
  Sasco AJ; Paffenbarger RS Jr
  Am  J  Epidemiol (UNITED  STATES)   Dec  1985,  122  (6)  p1017-31,
ISSN
0002-9262   Journal Code: 3H3
  Contract/Grant No.: CA 25264
  Languages: ENGLISH
  Document type: JOURNAL ARTICLE
  JOURNAL ANNOUNCEMENT: 8602
  Subfile:   INDEX MEDICUS
  A   case-control  analysis  of  Parkinson's  disease  and  infections
 in
childhood  was  conducted  in  a  cohort of 50,002 men who attended
Harvard
College  (Cambridge,  MA)  or the University of Pennsylvania
(Philadelphia,
PA)  between 1916 and 1950 and who were followed in adulthood for
morbidity
and  mortality  data.  Cases  of  Parkinson's  disease were identified
from
responses  to  mailed  questionnaires  and death certificates through
1978.
Four  controls  from  the  same  population  were selected for each
case. A
reduced  risk  of  Parkinson's  disease  was associated with most
childhood
viral  infections.  The  negative association was statistically
significant
for  a  history of measles prior to college entrance (exposure odds
ratio =
0.53;  95%  confidence limits: 0.31, 0.93). The reduced risk of
Parkinson's
disease  among subjects with a positive history of measles in childhood
may
reflect  an  adverse  effect  of  measles in adulthood or of subclinical
or
atypical measles. Furthermore, a negative history of measles, especially
if
associated  with  a  lack  of  other common diseases, could be a marker
for
negative  influenza history before 1918 and thus a higher risk of
infection
during  the  1918  influenza  epidemic,  because  of  the  lack  of
partial
influenza  immunity.  These data may also suggest a truly protective
effect
of  measles, compatible with some complex interaction between measles
virus
and the virus of the 1918 influenza epidemic.
  Tags: Human; Male; Support, Non-U.S. Gov't; Support, U.S. Gov't,
P.H.S.
  Descriptors:  *Measles--Complications--CO;  *Parkinson
Disease--Etiology
--ET; Adolescence; Adult; Aged; Child; Child, Preschool; Death
Certificates
; Epidemiologic Methods; Infant; Influenza--Complications--CO;
Longitudinal
Studies;  Massachusetts;  Measles--Epidemiology--EP;  Middle Age;
Parkinson
Disease--Epidemiology--EP;  Parkinson Disease--Mortality--MO;
Pennsylvania;
Questionnaires; Regression Analysis; Risk
 
 2/L/16
DIALOG(R)File 154:MEDLINE(R)
(c) format only 1995 Knight-Ridder Info. All rts. reserv.
 
05597157   85213157
  Why  was  the  1918  influenza pandemic so lethal? The possible role
of a
neurovirulent neuraminidase.
  Maurizi CP
  Med Hypotheses (ENGLAND)   Jan 1985,  16 (1) p1-5,  ISSN 0306-9877
Journal Code: M0M
  Languages: ENGLISH
  Document type: JOURNAL ARTICLE
  JOURNAL ANNOUNCEMENT: 8509
  Subfile:   INDEX MEDICUS
  Epidemiological,   viral,   behavioral   and  neuropathological
evidence
suggests  that  some influenza epidemics were neurovirulent.
Re-examination
of  the  data  from the lethal 1918 pandemic armed with recent
observations
about  the  influenza  virus  implicates a neurovirulent influenza virus
in
manic-depressive   disease,  schizophrenia  and  Parkinson's  disease.
The
neurovirulence seems to have been related to the species of
neuraminidase.
  Tags: Human
  Descriptors:  *Encephalitis--Etiology--ET;
*Neuraminidase--Toxicity--TO;
*Orthomyxoviridae--Enzymology--EN;   Antigens,  Viral--Analysis--AN;
Brain
--Pathology--PA;     Disease    Outbreaks;
Encephalitis--Immunology--IM;
 Encephalitis--Mortality--MO;   Influenza--Mortality--MO;
Orthomyxoviridae
--Pathogenicity--PY; Time Factors; Virulence
  CAS Registry No.: 0   (Antigens, Viral)
  Enzyme No.: EC 3.2.1.18   (Neuraminidase)
 
 2/L/17
DIALOG(R)File 154:MEDLINE(R)
(c) format only 1995 Knight-Ridder Info. All rts. reserv.
 
05526368   85142368
  Influenza and mania: a possible connection with the locus ceruleus.
  Maurizi CP
  South Med J (UNITED STATES)   Feb 1985,  78 (2) p207-9,  ISSN
0038-4348
Journal Code: UVH
  Languages: ENGLISH
  Document type: JOURNAL ARTICLE
  JOURNAL ANNOUNCEMENT: 8506
  Subfile:   AIM; INDEX MEDICUS
  I  have  presented  a possible case of mania induced by influenza B.
Some
epidemic influenza viruses may be neurovirulent. These epidemics seem to
be
associated   with   postencephalitic   Parkinson's   disease,   mania,
and
depression.    Viral,   neuroanatomic,   neurophysiologic,
neurochemical,
pharmacologic, clinical, and epidemiologic evidence can be found to
suggest
a  connection  between  the  locus  ceruleus,  the influenza virus, and
the
induction of a manic psychosis.
  Tags: Case Report; Human; Male
  Descriptors:   *Influenza--Complications--CO;  *Locus  Coeruleus;
*Manic
Disorder--Etiology--ET;     Adult;    Locus
Coeruleus--Microbiology--MI;
Orthomyxoviruses Type B
 
 3/L/4
DIALOG(R)File 154:MEDLINE(R)
(c) format only 1995 Knight-Ridder Info. All rts. reserv.
 
08981498   94296498
  Clinical  spectrum  of  secondary parkinsonism in childhood: a
reversible
disorder.
  Pranzatelli MR; Mott SH; Pavlakis SG; Conry JA; Tate ED
  Department  of  Neurology, George Washington University, Washington,
D.C.
20010.
  Pediatr   Neurol (UNITED   STATES)   Mar   1994,  10  (2)  p131-40,
ISSN
0887-8994   Journal Code: AA5
  Contract/Grant No.: FD-U-000746-01/2, FD, FDA; FD-U-000955-01, FD, FDA
  Languages: ENGLISH
  Document type: JOURNAL ARTICLE; REVIEW; REVIEW OF REPORTED CASES
  JOURNAL ANNOUNCEMENT: 9410
  Subfile:   INDEX MEDICUS
  Parkinsonism  is  an uncommon movement disorder in childhood. Six
unusual
cases  of  acquired  parkinsonism  in  hospitalized children are
described.
Clinical  manifestations  included  an  akinetic-rigid  syndrome  with
and
without  tremor,  the  combination  of  parkinsonism  and  dystonia,
and a
parkinsonism-plus  syndrome.  Altered mental status, mutism, dysphagia,
and
sialorrhea were frequent associations. Etiologies included
hypoxic-ischemic
encephalopathy;   haloperidol   treatment   with  and  without
neuroleptic
malignant  syndrome;  toxicity  of  cytosine arabinoside,
cyclophosphamide,
amphotericin   B,  and  methotrexate;  St.  Louis  encephalitis  and
other
encephalitides;  and  a  pineal  tumor with hydrocephalus. Cranial
magnetic
resonance  imaging  results  ranged  from  normal  to profound cerebral
and
cerebellar  atrophy  with  chemotherapeutic toxicity. The illnesses
usually
were  severe  enough  to  require  pharmacotherapy.  Incorrect diagnoses
of
depression  or catatonia delayed treatment or aggravated the problem.
Acute
treatment   included   amantadine,   levodopa/carbidopa   with  or
without
selegiline,  diphenhydramine,  or  benztropine.  The  concentration  of
CSF
homovanillic  acid  was normal in a neuroleptic-associated patient, but
the
level  was  low  in  an  encephalitic  patient.  All  patients
demonstrated
dramatic improvement, including two who were not treated; some had
complete
resolution  of  symptoms and none required continued antiparkinsonian
drugs
despite poor scores on the Unified Parkinson's Disease Rating Scale and
the
Modified Hoehn and Yahr Rating Scales. The causes of parkinsonism
described
are  more  common  in  a  general  pediatric hospital than the
parkinsonism
associated with the popularized Segawa syndrome.  (52 Refs.)
  Tags: Case Report; Female; Human; Male; Support, Non-U.S. Gov't;
Support,
U.S. Gov't, P.H.S.
  Descriptors:  *Parkinson Disease, Symptomatic--Etiology--ET;
Adolescence;
Antiparkinson    Agents--Adverse    Effects--AE;     Antiparkinson
Agents
--Therapeutic  Use--TU; Atrophy; Brain--Drug Effects--DE;
Brain--Pathology
--PA; Child; Diagnosis, Differential; Follow-Up Studies; Magnetic
Resonance
Imaging;   Neurologic  Examination--Drug  Effects--DE;  Parkinson
Disease,
Symptomatic--Chemically   Induced--CI;    Parkinson   Disease,
Symptomatic
--Diagnosis--DI;    Parkinson   Disease,   Symptomatic--Drug
Therapy--DT;
Psychoses,  Substance-Induced--Diagnosis--DI;  Psychoses,
Substance-Induced
--Etiology--ET; Tomography, X-Ray Computed
  CAS Registry No.: 0   (Antiparkinson Agents)
 
 3/L/5
DIALOG(R)File 154:MEDLINE(R)
(c) format only 1995 Knight-Ridder Info. All rts. reserv.
 
08794985   94109985
  Birthplace  as  a  risk  factor  in motor neurone disease and
Parkinson's
disease.
  Betemps EJ; Buncher CR
  University of Cincinnati College of Nursing and Health, OH 45221.
  Int J Epidemiol (ENGLAND)   Oct 1993,  22 (5) p898-904,  ISSN
0300-5771
Journal Code: GR6
  Languages: ENGLISH
  Document type: JOURNAL ARTICLE
  JOURNAL ANNOUNCEMENT: 9404
  Subfile:   INDEX MEDICUS
  A  proportional  mortality  study  was conducted to determine if state
of
birth  is  a  risk  factor  associated with motor neurone disease (MND)
and
Parkinson's  disease  (PD) using US death certificate information for
1981.
State  of  birth  was  used  as  a surrogate variable for location of
early
childhood  environment.  A  gradient of risk by geographical area in the
US
was found for MND and PD. Cerebral vascular accident (CVA) deaths served
as
a  comparison  group.  Multiple  sclerosis  (MS)  deaths  were  analysed
to
validate  the  methods  used.  A geographical relationship between
latitude
proportional  mortality  ratios for MND, PD and MS by state of birth,
and a
geographical  relationship  between  latitude  and  proportional
mortality
ratios  for  MND and MS by state of birth were found. Statistical
modelling
was used to compare the deaths from MND, PD, MS, CVA to all other deaths
in
the  US by state of birth. The resulting models were evaluated to
determine
if  any  individual  states were not well represented by the model for
each
disease.  As  predicted,  no  pattern was evident for CVA. The
geographical
gradient   observed   for  MS  was  as  predicted  by  other  studies.
The
geographical  pattern  found  for MND has a northwest to southeast
gradient
and the pattern found for PD has a west to east gradient.
  Tags: Comparative Study; Female; Human; Male; Support, Non-U.S. Gov't
  Descriptors:  *Motor Neuron Disease--Epidemiology--EP; *Parkinson
Disease
--Epidemiology--EP;  Cause  of  Death; Cerebrovascular
Disorders--Mortality
--MO;   Death  Certificates;  Models,  Statistical;  Motor  Neuron
Disease
--Mortality--MO;   Multiple   Sclerosis--Mortality--MO;  Parkinson
Disease
--Mortality--MO; Risk Factors; United States--Epidemiology--EP
 
 3/L/9
DIALOG(R)File 154:MEDLINE(R)
(c) format only 1995 Knight-Ridder Info. All rts. reserv.
 
08721869   94036869
  Parkinsonian syndrome in childhood after sodium valproate
administration.
  Alvarez-Gomez  MJ;  Vaamonde  J; Narbona J; Barao M; Barona P; Brannan
T;
Gudin M; Ibanez R
  Pediatric Neurology Unit, University of Navarra, Pamplona, Spain.
  Clin  Neuropharmacol (UNITED  STATES)   Oct  1993,  16  (5) p451-5,
ISSN
0362-5664   Journal Code: CNK
  Languages: ENGLISH
  Document type: JOURNAL ARTICLE
  JOURNAL ANNOUNCEMENT: 9402
  Subfile:   INDEX MEDICUS
  Among the side effects attributed to sodium valproate administration,
the
production  of  a  parkinsonian  syndrome is very uncommon, particularly
in
children.  We  report  a  12-year-old  girl with secondary epilepsy; 7
days
after  the  initiation of valproate therapy she developed parkinsonism
that
disappeared  completely  when  valproate  was replaced by carbamazepine.
We
discuss  the possible role of alterations in GABAergic neurotransmission
in
the extrapyramidal syndrome that developed.
  Tags: Case Report; Female; Human
  Descriptors:  *Parkinson  Disease,  Symptomatic--Chemically
Induced--CI;
*Valproic Acid--Adverse Effects--AE; Child
  CAS Registry No.: 99-66-1   (Valproic Acid)
 
 3/L/17
DIALOG(R)File 154:MEDLINE(R)
(c) format only 1995 Knight-Ridder Info. All rts. reserv.
 
08185442   92323442
  Life-style and dietary factors early and late in Parkinson's disease.
  Vieregge P; von Maravic C; Friedrich HJ
  Klinik  fur  Neurologie,  Medizinische  Universitat  zu  Lubeck,
Federal
Republic of Germany.
  Can J Neurol Sci (CANADA)   May 1992,  19 (2) p170-3,  ISSN 0317-1671
Journal Code: CJ9
  Languages: ENGLISH
  Document type: JOURNAL ARTICLE
  JOURNAL ANNOUNCEMENT: 9210
  Subfile:   INDEX MEDICUS
  The  study  investigated  features of life-style and dietary habits
early
and  late  in  life  of patients with idiopathic Parkinson's disease
(IPD).
Seventy-one  patients  and  103 controls were interviewed personally
with a
structured questionnaire. Living in villages during primary school time
was
significantly  more  frequent  among patients, and in the urban
environment
patients   had  lived  less  frequently  in  larger-sized  towns.
Mushroom
harvesting during childhood was more frequent among patients. No
difference
between  patients  and controls was found in childhood water supply,
habits
of  fishing  in  the  countryside  or at the seaside, and eating such
fish.
Actual food preference in patients was greater for almonds and plums,
while
no  difference  was  found  in  the  actual  intake  of mushrooms,
peanuts,
oil-dressed  salad,  fish  and  animal offals. The study did not
indicate a
higher consumption of foods known to harbour heavy metals and pesticides
in
IPD  patients either long before or during the disease. Reduced
consumption
of  foodstuffs  rich  in  vitamin  E,  as reported previously for
premorbid
patients, is no longer observed in patients with overt disease.
  Tags: Animal; Female; Human; Male
  Descriptors:  *Food  Habits;  *Life Style; *Parkinson
Disease--Psychology
--PX;  Adolescence;  Adult;  Aged;  Basidiomycetes;  Cookery; Fishes;
Meat;
Metals--Analysis--AN;  Middle  Age; Questionnaires; Rural Population;
Urban
Population; Water Supply--Analysis--AN
  CAS Registry No.: 0   (Metals)
 
 3/L/18
DIALOG(R)File 154:MEDLINE(R)
(c) format only 1995 Knight-Ridder Info. All rts. reserv.
 
07867018   92005018
  Parkinson's  disease  and  exposure  to  rural  environmental
factors: a
population based case-control study.
  Semchuk KM; Love EJ; Lee RG
  Department of Community Health Sciences, University of Calgary,
Canada.
  Can J Neurol Sci (CANADA)   Aug 1991,  18 (3) p279-86,  ISSN 0317-1671
Journal Code: CJ9
  Languages: ENGLISH
  Document type: JOURNAL ARTICLE
  JOURNAL ANNOUNCEMENT: 9201
  Subfile:   INDEX MEDICUS
  To determine whether a history of exposure to rural environmental
factors
leads  to  an  increased  likelihood  of  developing idiopathic
Parkinson's
disease,  we  conducted  a case-control study of 130 cases and 260
randomly
selected  community controls (matched with the cases by sex and age +/-
2.5
years  at  a  ratio of 2 controls: 1 case) in the city of Calgary. The
data
were  collected  by personal interviews and were analyzed using
conditional
logistic  regression  for  matched  sets. The ages of the cases ranged
from
36.5  to 90.7 years (mean = 68.5 +/- 11.3 years). The mean age at
diagnosis
was  61.1  +/-  12.4  years.  The  mean duration of disease was 7.8 +/-
0.6
years.  Eleven  (9.1%)  cases  were diagnosed before age 40. In this
sample
from  the  Province of Alberta, Canada, no significant increase in risk
for
Parkinson's  disease  was  associated  with a history of rural living,
farm
living, or well water drinking in early childhood or at any time during
the
first 45 years of life.
  Tags: Female; Human; Male; Support, Non-U.S. Gov't
  Descriptors:  *Environmental  Exposure;  *Parkinson
Disease--Epidemiology
--EP;  *Rural Health; Adult; Aged; Aged, 80 and over;
Alberta--Epidemiology
--EP; Case-Control Studies; Middle Age; Regression Analysis; Risk
Factors
 
 3/L/21
DIALOG(R)File 154:MEDLINE(R)
(c) format only 1995 Knight-Ridder Info. All rts. reserv.
 
07681441   91200441
  Encephalitis lethargica-like illness in a five-year-old.
  Mellon AF; Appleton RE; Gardner-Medwin D; Aynsley-Green A
  Newcastle General Hospital.
  Dev   Med   Child  Neurol (ENGLAND)   Feb  1991,  33  (2)  p158-61,
ISSN
0012-1622   Journal Code: E83
  Languages: ENGLISH
  Document type: JOURNAL ARTICLE
  JOURNAL ANNOUNCEMENT: 9107
  Subfile:   INDEX MEDICUS
  A  five-year-old  boy  presented  with  an  encephalitis
lethargica-like
illness,  characterised by somnolence, mutism and Parkinsonian rigidity
two
weeks  after  an  acute  exanthem.  Investigation  revealed increased
serum
measles   antibody   titre.  He  made  a  complete  recovery.
Encephalitis
lethargica  associated  with  Parkinsonism in childhood is rare and
usually
carries a poor prognosis.
  Tags: Case Report; Human; Male
  Descriptors: *Arousal--Physiology--PH;
*Encephalomyelitis--Diagnosis--DI;
*Neurologic  Examination--Methods--MT; *Parkinson Disease,
Postencephalitic
--Diagnosis--DI;    Akinetic    Mutism--Diagnosis--DI;    Akinetic
Mutism
--Physiopathology--PP;    Brain--Physiopathology--PP;   Child,
Preschool;
Encephalomyelitis--Physiopathology--PP;    Follow-Up   Studies;
Parkinson
Disease, Postencephalitic--Physiopathology--PP; Spinal
Cord--Physiopatholog
y--PP
 
==============================================================
 
Part Two to Follow
 
Best,
 
Bob
 
--
********************************************************
 
Robert A. Fink, M. D., F.A.C.S.   Phone: 510-849-2555
Neurological Surgery              FAX:  510-849-2557
2500 Milvia Street  Suite 222
Berkeley, California 94704-2636
USA
 
E-Mail:  [log in to unmask]
CompuServe:  72303,3442
America Online:  BobFink          "Ex Tristitia Virtus"
 
********************************************************