Announcing the Cure for Parkinson’s Disease
Looking for doctors to try a new treatment and send observations
(Pardon the length of this document.  You cannot describe a useful brain
theory in a sound bite.)
The Treatment (Part 4)
This comes in 7 parts.  Do not apply any of this information without reading
all 7 parts.  Each part will have words at the end saying "continued in
 Parkinson’s Disease Cure’ Part [#]" for those whose servers might truncate
these documents.

Table of Contents
Introduction................................................................
...........................Part 1
Some of my theory helpful to understanding this
treatment....................Part 2
Some of my theory helpful to understanding this treatment
(cont.).........Part 3
The
Treatment...................................................................
....................Part 4
The Treatment
(cont.).....................................................................
.......Part 5
Why announce it this way on the
Internet?.............................................Part 6
Why approach Parkinson’s disease
first?................................................Part 7
The Treatment
Candidates
The first candidates for testing this treatment should be screened for
problems that might become critical during a period of withdrawal.  When we
know more about this treatment these things may not matter so much, but at
this time we have to act as safely as possible.
Some doctors might choose to try an unknown procedure first on those
patients that are no longer responding to conventional treatment.  This is
usually a moral choice.  This treatment might be a little bit different in
that you should understand that the greater the problem with the disorder
and the greater the progression of the disease, then the greater the
discomfort during a period of withdrawal.
The first people to try this should not be diabetic, epileptic, or suffering
from heart disease.  It is best that candidates be able to function without
taking any other medication during a period of two months.
Age matters.  The older you are the greater the withdrawal to be
experienced.
As nervous function returns, old forgotten pains can return too.  These will
diminish eventually in most cases but there might be exceptions.  For
instance, the pain of a severed limb or an old operation might return for
some time with increased sensation.  (The neurological damage from a severed
body part can never be totally repaired through healing.  Sometimes it is
best when functioning diminishes in a small part of the nervous system.)
I will send updates as I learn more about problems with various candidates.
Preparation
Several different factors need to be controlled during this treatment for
success.  (Of those who have done this so far, it was not always possible to
provide these controls but every treatment was still successful to a great
extent.)
This may be very important for some people:  remove all allergens from the
patient’s diet and atmosphere.  This alone might be enough for some people
to start getting better (and/or to send that person into withdrawal).
Stay away from common diet items.  Test for allergies if possible.  Have the
patient spend time in comfortable places during the treatment if possible.
Spend time with enjoyable people during the treatment.  (Some patients may
have developed an allergy to their doctors and to the hospital.)
(The hospital might be the worst place for making this treatment work.
Something needs to be done to create the most healing atmosphere.  But these
people will need supervision and support, at least during the worst few days
of the withdrawal.  They need to be protected in case they become suicidal
or have a heart attack during a stressful period of withdrawal.  New
techniques will probably eliminate these risks if most of the withdrawal can
be facilitated during sleep.)
The patient should stop taking all medications prior to starting on the
methylphenidate.
No drugs or alcohol or cigarettes or caffeine (skip the chocolate) or
allergens during the treatment and for at least a month after the treatment.
(You want to be cured, don’t you?!?)  (If you worry about trying to kick
your cigarette habit, for instance, along with enduring the stress of this
treatment, you should realize that this treatment is an accelerated
withdrawal so that the experience of giving up a substance during this
treatment will actually be easier than without the treatment.  The results
will be more permanent as well.  This is the time to give up smoking for
good.)
Each patient needs to be well-prepared for all possible withdrawal symptoms.
Knowing that these states might come is very helpful in getting through
them.
Every change in functioning that has ever come to any person during any kind
of withdrawal from drugs could occur during this withdrawal as well.  This
will all be minimized if the right dosage is found, but nobody has enough
experience with this treatment to know the optimal dosage.
(Everybody who does this will have some kind of withdrawal.  This same
treatment will cause supposedly healthy people to go into withdrawal.
Everybody after a certain age has some part of their brain that is slower
than the rest and will benefit from such a withdrawal.  The only thing that
would keep a person from having some kind of withdrawal with this treatment
would be a recent treatment or a very unusual state of health.)
Tremor, panic attacks, seizures, suicidal depression, delusions,
hallucinations, physical illness, anger...  all is possible.  But none of
these may occur if the parts of the brain responsible for such states go
through their withdrawals during sleep.  With the right dosage this will be
a very speedy withdrawal and most swings in mood and functioning will change
quickly.  For instance a delusional or suicidal state will most likely be
changed in a few hours.
The patient needs to know ahead of time that if this treatment is working
right they will go through a period of no-confidence during the worst day or
two of a particular dosage (especially the first dosage).  The brain is
doing the thinking and the brain is going through the withdrawal.  Even if
this treatment works on a million people with no failures and everyone
thinks it to be successful, the person going through the worst of the
withdrawal will think (feel) that this is the biggest mistake in the world
and they may demand to stop.  Being told ahead of time that they will act
this way is helpful in getting them through the treatment.  (Everyone needs
support to get through this treatment.)  Having some part of their brain
taught that this is to be expected makes it easier for those helping them
through the process to convince them to stick with it.  The support staff
will need to remind the patient that they were told ahead of time that they
were going to want to stop the treatment.  (This is the problem with most
people’s thinking:  logic versus emotion.)
The patient needs to set aside two months without much responsibility or
stress.  The patient is, in effect, sleeping off the illness with this
treatment and needs to be able to sleep whenever possible.
Women who are still experiencing menstrual periods should consider timing
the treatment so that it doesn’t end during or just before their
pre-menstrual cycle.  The first couple of weeks after the treatment are when
the brain is relearning a new set of sensitivities and making it possible
for this cure to become permanent.  During the early weeks following the
treatment each patient will be more susceptible to change under stress.
Some milder symptoms will return at the end of the day when tired, or when
pre-menstrual, or under other stresses (don’t drink or do drugs and
caffeine!).  As long as the patient sleeps as much as possible during this
post-treatment phase, the returning symptoms will be less likely to return.
(The brain is growing, exercising during this period when it is now able to
turn chemical changes into permanent long-term memory changes.  Having
symptoms come back at the end of the day is like having shaky muscles after
a day of weight-lifting.  The body-builder needs to rest the muscles to give
them a chance to grow, just as much as needing to exercise them.)
The patient must be prepared for the possibility that this will not work for
them.  If it doesn’t remove their symptoms (probably because of too much
atrophy in the brain), it will probably change the nature of their problem.
This treatment is a chemical reset of the brain and creates an enormous
amount of change.
Why methylphenidate (Ritalin)?
It is possible that this kind of technique might work using L-Dopa which
affects only one neurotransmitter but it is not as likely.  The best version
of this technique for the future will probably involve drugs that affect a
wider array of excitatory brain messengers (and/or neurochemicals that serve
as an eventual catalyst to more reactivity to excitation).
CNS stimulants will work because they affect the switchboard of the brain,
the part of the brain with the most direct connections to other parts of the
brain.  Changes in this part of the brain will be communicated electrically
to other parts of the brain that use different messengers and the balances
of those other messengers will change as a result.
Other CNS stimulants will work on most people but methylphenidate is the
best choice I can see.  (The treatment worked for one person who used
Dexedrine instead of Ritalin.)
Methylphenidate (Ritalin) has a very safe history at much higher dosages
than are used in this treatment.  (I know of somebody who was all right
after taking a dose that was 500 times greater than the dose I’ll suggest as
the maximum for this treatment.)  There have been no significant problems
from long-term use of methylphenidate.
It is easy to divide and is water soluble.   In order to get the dosages
right, we have taken a 10mg tablet (do not use the slow release SR version)
and crushed it and stirred it into water.  Dividing the water makes it easy
to get an accurate division of the pill.  Always stir when dealing with
Ritalin in solution because it doesn’t take long for it to settle to the
bottom.
Dexedrine is more of a controlled substance, has a more problematic history,
and is difficult to divide into smaller dosages.  I’m also bothered by it
containing (small) talc and dairy components as both are allergens to many
people.
Getting a consistent dosage during sleep is problematic.  It will be best if
a delivery system is developed that ensures an even dosage for a long enough
time.  This may not be possible taking the drug orally.  I’ve heard of a
patch that is being developed for L-Dopa and I’m aware that attempts to put
Ritalin into a patch have failed because of problems with absorbing that
drug through the skin.  (Apparently the molecule is too large.)
An intravenous delivery during sleep might be best although I’m bothered by
the idea of decreasing the comfort of sleep with the needle in the arm and
also bothered by the hospital environment that this requires.  (The sense of
touch improves during the course of treatment so that the needle is going to
hurt more and more each day it is put into the arm.)

Dosage
Sleep is 24 hours a day.  The medication should not be enough to increase
the firings in the brain very much.  It works on the nerves when they are
dormant for a long enough period of time.  While they are asleep.   Most
cells are not firing at any one time so many are "asleep" during the day as
well.  Sites that are firing the most during the day will need the treatment
during the night as well.  The medication must be taken continuously
whenever nerves are not firing so it must be 24 hours a day.  If the dosage
is too high with these stimulants the firings will increase too much and
create a paradoxically opposite effect.  There is a wide range of
sensitivities to any particular level of any chemical in the brain among
various nerve sites.  Some receptors will be so sensitive that extremely
small amounts of medication will create this paradoxical response so the
treatment needs to be repeated at successively smaller dosages.
This medication has to be administered much more like the body administers
its own medications to itself.  Very small changes in the chemical balance
of the nervous system rather than massive influxes of chemical rising and
falling because of the vagaries of digestion and elimination while taking
these medications a few times a day.
For the first week or so the patient will take a dosage that doesn’t create
too much immediate change in functioning.  This dosage will enhance sleep.
Within a day or two the patient will be sleeping more deeply and the
sleeping disorder patterns will improve fairly quickly.
If the medication is keeping the person from sleeping at night for more than
two nights it then should be lowered.
This starting dosage taken during the first wave of withdrawal will be the
largest dose.  I suggest starting with 2mg (two milligrams) of
methylphenidate per hour.  If this is getting in the way of sleeping after
three nights, take the dose down to 1mg (one milligram) per hour.  Most
people will become drowsy and sleep more taking the medication this way.
Some with Parkinson’s Disease will be able to sleep on much higher dosages
but it is best to not get carried away.
I really don’t know if it is best to start on 1mg per hour or 2mg or 3mg.
These things will be learned in time.  It will probably work with any of
these three dosages but there is a trick here.  You want to accelerate the
withdrawal as much as possible without interrupting sleep.  One dosage might
make things move quickly but cause too much of the brain to go into
withdrawal at the same time and make the experience more unpleasant.
Another starting dosage might not involve enough of the brain.  Starting at
a higher dosage might mean going through the process more times as the
treatment is repeated with smaller dosages.
This is important:  the dosage should be taken every hour as promptly as
possible.  This medication tends to stay in the system for more than a
couple of hours in most people and taking it hourly keeps the medication
level in the system from having too many peaks and valleys.   Taking half as
much every half hour might be even better for getting the best results, but
there is a limit to how much hassle is acceptable.
During the night it would be best if there was a consistent delivery system
that didn’t require waking the person for the next dose.  So far, everyone
who has done this has taken the same medication at bedtime and was aroused
to take the next doses every 2½ or 3 hours later.  (Everyone tended to wake
up without prompting or alarms about the time the dose would be wearing
off...  the body seems to crave this medication during sleep.)
It might work better if the dose an hour before bedtime is skipped and a
double dose is taken at bedtime and in the middle of the night.  As long as
this dosage does not interrupt the sleep it basically keeps the same level
of medication in the system during sleep as during the day (but with more
peaks and valleys).
The whole trick here is in striking a balance between doing the best job
possible keeping the medication at the right level and interrupting the
sleep as little as possible.  (Avoiding sleep interruption is another thing
that hospitals have been poor at providing.  If the person going through
this therapy is medicated and is sleeping, never wake that person for any
reason.  Hospital staffs might have to be retrained in this regard.  This
entire treatment is based on sleeping off many layers of withdrawal.)
[CONTINUED in ‘ Parkinson’s Disease Cure’ Part 5]