|
PARKINSN Archives
|
PARKINSN@LISTSERV.UTORONTO.CA
|
|
|
|
Here's info te TASMAR (Tolcapone) which was requested
>Date: Mon, 02 Feb 1998 12:12:09 -0500 (EST)
>From: "LIST Helen K. Mason" <[log in to unmask]>
>Subject: TASMAR
>Sender: Parkinson's Information Exchange <[log in to unmask]>
>To: Multiple recipients of list PARKINSN <[log in to unmask]>
>Reply-to: Parkinson's Information Exchange <[log in to unmask]>
>Date: Friday, January 30, 1998 5:33:42 PM
>From: AOL News
>Subj: FDA Clears Parkinson's Drug TASMAR(R) Tolcapone) for...
>
>FDA Clears Parkinson's Drug TASMAR(R) Tolcapone) for U.S. Marketing; First of
>a New Class of Drugs Called COMT Inhibitors
>
>NUTLEY, N.J., Jan. 30 /PRNewswire/ -- Hoffmann-La Roche announced today that
>it received clearance from the U.S. Food and Drug Administration to market
>TASMAR(R) (tolcapone), the first of a new class of Parkinson's disease drugs
>called COMT inhibitors. TASMAR significantly improves a patient's ability to
>function and perform basic daily activities when taken in combination with the
>current standard of therapy, levodopa/carbidopa. Clinical studies found that
>advanced Parkinson's disease patients gained a daily average of 1.7 - 2.9
>hours of "on" time, periods of relatively good functioning, with the combined
>therapy.
>
>TASMAR is indicated for use in conjunction with levodopa/carbidopa, in both
>"non-fluctuating" and "fluctuating" Parkinson's disease patients. TASMAR was
>evaluated in patients whose Parkinson's disease was characterized by
>deterioration in their response to levodopa at the end of a dosing interval
>("fluctuating patients" with wearing-off phenomena). Additionally it was
>evaluated in patients whose response to levodopa was relatively stable ("non-
>fluctuators").
>
>A progressive neurological disorder, Parkinson's disease affects one and one-
>half million Americans. Symptoms include uncontrollable tremors or shaking,
>slowness of movements, stiffness, poor balance and a shuffling walk. There is
>no cure for Parkinson's disease; current therapies focus on symptom control.
>
>"TASMAR is an important new option for the treatment of Parkinson's disease.
>When used in conjunction with levodopa, patients experience rapid and
>significant improvement in many of their symptoms," said William Koller, M.D.,
>Chairman, Department of Neurology, University of Kansas Medical Center.
>"Patients enjoy fewer tremors, improved mobility and overall improvement in
>conducting daily activities."
>
>Clinical Trials Demonstrate Improvement
>
>In worldwide clinical trials with more than 1,500 patients, TASMAR was shown
>to enhance and extend the pharmacologic actions and clinical benefits of
>levodopa/carbidopa.
>
>Non-fluctuating patients taking TASMAR experienced statistically significant
>improvements in activities of daily living as assessed by the Unified
>Parkinson's Disease Rating Scale (UPDRS), which measures such activities as
>speech, handwriting, walking and dressing. These patients also experienced
>improved motor function.
>
>In clinical studies, fluctuating patients gained a daily average of 1.7 - 2.9
>hours of "on-time". In addition, these patients experienced a significant
>improvement in their symptoms, overall, as measured by the investigator's
>global assessment of change.
>
>COMT Inhibition
>
>While the precise mechanism-of-action is unknown, it is believed that COMT
>inhibitors work to enhance the effectiveness of levodopa by blocking one of
>the main enzymes (catechol-O-methyltransferase) responsible for breaking down
>levodopa in the bloodstream, before it reaches the brain.
>
>By inhibiting the action of the COMT enzyme, TASMAR, a COMT inhibitor,
>provides smoother and more sustained levels of levodopa to the brain which it
>is believed translates into more consistent and effective symptom relief for
>people with Parkinson's disease.
>
>Extending the benefit of levodopa is important. Over time, Parkinson's
>disease progresses and larger and/or more frequent doses of levodopa are
>needed to relieve Parkinson's symptoms. Patients experience levodopa-induced
>side effects, like uncontrolled movements (dyskinesias) and begin to fluctuate
>between periods of relatively good functioning ("on-time") and periods of
>relatively poor functioning ("off-time"). Clinical studies demonstrated that
>by extending the effectiveness of each dose of levodopa, TASMAR helped to
>"smooth out" these on-off periods -- thus increasing patients' functioning
>throughout the day.
>
>"This is an exciting time for new research and treatment developments to
>manage Parkinson's disease. Although we're still looking for a cure, COMT
>inhibitors represent an entirely new class of therapy that will help the many
>Parkinson's disease patients to attain better symptom control," said Emilio
>Alonso-Mendoza, executive director, National Parkinson Foundation.
>
>In clinical trials, the most common side effects were dyskinesias (involuntary
>movements), nausea, sleep disorders, dystonia, anorexia, diarrhea, somnolence,
>excessive dreaming, muscle cramps, orthostatic complaints/syncope, dizziness,
>headache, hallucination and confusion. TASMAR may potentiate the dopaminergic
>side effects of levodopa and may require decreasing the dose of levodopa;
>however some may persist despite levodopa dose adjustment. Diarrhea was the
>side effect which most commonly led to discontinuation. Liver transaminases
>should be monitored when initiating TASMAR and as recommended for the first 6
>months.
>
>To be marketed by Hoffmann-La Roche, TASMAR will be supplied in 100 mg. and
>200 mg. tablets. It will be available in pharmacies nationwide beginning late
>February.
>
>Hoffmann-La Roche Inc. is a leading research-intensive pharmaceutical company
>that discovers, develops, manufactures and markets numerous important
>prescription drugs that improve, prolong and save the lives of patients with
>serious illnesses. Hoffmann-La Roche has a strong history in the Parkinson's
>disease arena as the developer of LARODOPA(TM) (levodopa), (the first levodopa
>product), and MADOPAR(TM) (levodopa/benserazide), the leading Parkinson's
>medication used outside the U.S. Among the company's areas of therapeutic
>interest are central nervous system disorders, virology, including HIV and
>AIDS, infectious diseases, cardiology, oncology, transplantation, dermatology
>and obesity.
>
>The company provides a wide range of medications in the United States through
>its marketing and sales subsidiary, Roche Laboratories Inc. Headquartered in
>Nutley, N.J., both companies are members of the Basel, Switzerland-based Roche
>Group, a global leader in health care with principal businesses in
>pharmaceuticals, diagnostics, vitamins, and fragrances and flavors.
>
>NOTE: Full prescribing information available upon request.
>
>.
>
|
|
|
|
|
Archives |
March 2024, Week 4 January 2022, Week 4 November 2021, Week 4 February 2021, Week 2 December 2020, Week 2 October 2020, Week 4 June 2020, Week 4 May 2020, Week 2 May 2020, Week 1 April 2020, Week 5 April 2020, Week 1 March 2020, Week 5 March 2020, Week 4 March 2020, Week 2 March 2020, Week 1 February 2020, Week 4 February 2020, Week 3 February 2020, Week 1 January 2020, Week 5 January 2020, Week 2 October 2019, Week 1 September 2019, Week 5 September 2019, Week 3 July 2019, Week 1 June 2019, Week 5 June 2019, Week 4 June 2019, Week 3 June 2019, Week 1 April 2019, Week 5 April 2019, Week 4 April 2019, Week 2 March 2019, Week 5 March 2019, Week 3 March 2019, Week 2 March 2019, Week 1 February 2019, Week 4 January 2019, Week 3 January 2019, Week 2 January 2019, Week 1 December 2018, Week 5 December 2018, Week 4 December 2018, Week 2 November 2018, Week 3 November 2018, Week 2 November 2018, Week 1 October 2018, Week 4 October 2018, Week 3 October 2018, Week 1 September 2018, Week 4 September 2018, Week 3 August 2018, Week 4 August 2018, Week 3 August 2018, Week 1 July 2018, Week 4 July 2018, Week 3 July 2018, Week 2 July 2018, Week 1 June 2018, Week 5 June 2018, Week 3 June 2018, Week 1 May 2018, Week 5 May 2018, Week 4 May 2018, Week 3 May 2018, Week 2 May 2018, Week 1 April 2018, Week 4 April 2018, Week 3 April 2018, Week 2 February 2018, Week 3 January 2018, Week 5 January 2018, Week 2 January 2018, Week 1 December 2017, Week 4 December 2017, Week 3 December 2017, Week 1 November 2017, Week 5 November 2017, Week 4 November 2017, Week 3 November 2017, Week 2 November 2017, Week 1 October 2017, Week 4 October 2017, Week 2 October 2017, Week 1 September 2017, Week 5 September 2017, Week 4 September 2017, Week 3 September 2017, Week 2 September 2017, Week 1 August 2017, Week 4 August 2017, Week 2 August 2017, Week 1 July 2017, Week 5 July 2017, Week 4 July 2017, Week 3 July 2017, Week 2 July 2017, Week 1 June 2017, Week 5 June 2017, Week 4 June 2017, Week 3 June 2017, Week 2 June 2017, Week 1 May 2017, Week 5 May 2017, Week 4 May 2017, Week 3 May 2017, Week 2 May 2017, Week 1 April 2017, Week 3 April 2017, Week 2 April 2017, Week 1 March 2017, Week 4 March 2017, Week 3 March 2017, Week 2 March 2017, Week 1 February 2017, Week 3 February 2017, Week 2 February 2017, Week 1 January 2017, Week 4 January 2017, Week 2 January 2017, Week 1 December 2016, Week 5 December 2016, Week 4 December 2016, Week 2 December 2016, Week 1 November 2016, Week 4 November 2016, Week 3 November 2016, Week 2 November 2016, Week 1 October 2016, Week 4 October 2016, Week 3 October 2016, Week 1 September 2016, Week 3 September 2016, Week 2 September 2016, Week 1 August 2016, Week 4 July 2016, Week 5 July 2016, Week 4 July 2016, Week 3 July 2016, Week 2 July 2016, Week 1 June 2016, Week 5 June 2016, Week 3 June 2016, Week 2 June 2016, Week 1 May 2016, Week 5 May 2016, Week 4 May 2016, Week 3 May 2016, Week 2 May 2016, Week 1 April 2016, Week 5 April 2016, Week 4 April 2016, Week 3 April 2016, Week 2 April 2016, Week 1 March 2016, Week 5 March 2016, Week 4 March 2016, Week 3 March 2016, Week 2 March 2016, Week 1 February 2016, Week 5 February 2016, Week 4 February 2016, Week 3 February 2016, Week 2 February 2016, Week 1 January 2016, Week 5 January 2016, Week 4 January 2016, Week 3 January 2016, Week 2 January 2016, Week 1 December 2015, Week 5 December 2015, Week 4 December 2015, Week 3 December 2015, Week 2 December 2015, Week 1 November 2015, Week 5 November 2015, Week 3 November 2015, Week 2 November 2015, Week 1 October 2015, Week 5 October 2015, Week 4 October 2015, Week 3 October 2015, Week 2 October 2015, Week 1 September 2015, Week 5 September 2015, Week 4 September 2015, Week 3 September 2015, Week 2 September 2015, Week 1 August 2015, Week 5 August 2015, Week 4 August 2015, Week 3 August 2015, Week 2 August 2015, Week 1 July 2015, Week 5 July 2015, Week 4 July 2015, Week 3 July 2015, Week 2 July 2015, Week 1 June 2015, Week 5 June 2015, Week 4 June 2015, Week 3 June 2015, Week 2 June 2015, Week 1 May 2015, Week 5 May 2015, Week 4 May 2015, Week 3 May 2015, Week 2 May 2015, Week 1 April 2015, Week 4 April 2015, Week 3 April 2015, Week 2 April 2015, Week 1 March 2015, Week 5 March 2015, Week 4 March 2015, Week 3 March 2015, Week 2 March 2015, Week 1 February 2015, Week 4 February 2015, Week 3 February 2015, Week 2 February 2015, Week 1 January 2015, Week 5 January 2015, Week 4 January 2015, Week 3 January 2015, Week 2 December 2014, Week 5 December 2014, Week 4 December 2014, Week 3 December 2014, Week 2 December 2014, Week 1 November 2014, Week 5 November 2014, Week 4 November 2014, Week 3 November 2014, Week 2 November 2014, Week 1 October 2014, Week 5 October 2014, Week 4 October 2014, Week 3 October 2014, Week 2 October 2014, Week 1 September 2014, Week 5 September 2014, Week 4 September 2014, Week 3 September 2014, Week 2 September 2014, Week 1 August 2014, Week 5 August 2014, Week 4 August 2014, Week 3 August 2014, Week 2 August 2014, Week 1 July 2014, Week 5 July 2014, Week 4 July 2014, Week 3 July 2014, Week 2 July 2014, Week 1 June 2014, Week 5 June 2014, Week 4 June 2014, Week 3 June 2014, Week 2 June 2014, Week 1 May 2014, Week 4 May 2014, Week 3 May 2014, Week 2 May 2014, Week 1 April 2014, Week 5 April 2014, Week 4 April 2014, Week 3 April 2014, Week 2 April 2014, Week 1 March 2014, Week 5 March 2014, Week 4 March 2014, Week 3 March 2014, Week 2 March 2014, Week 1 February 2014, Week 4 February 2014, Week 3 February 2014, Week 2 February 2014, Week 1 January 2014, Week 5 January 2014, Week 4 January 2014, Week 3 January 2014, Week 2 January 2014, Week 1 December 2013, Week 5 December 2013, Week 4 December 2013, Week 3 December 2013, Week 2 December 2013, Week 1 November 2013, Week 4 November 2013, Week 3 November 2013, Week 2 November 2013, Week 1 October 2013, Week 5 October 2013, Week 4 October 2013, Week 3 October 2013, Week 2 October 2013, Week 1 September 2013, Week 5 September 2013, Week 4 September 2013, Week 3 September 2013, Week 2 September 2013, Week 1 August 2013, Week 5 August 2013, Week 4 August 2013, Week 3 August 2013, Week 2 August 2013, Week 1 July 2013, Week 5 July 2013, Week 4 July 2013, Week 3 July 2013, Week 2 July 2013, Week 1 June 2013, Week 5 June 2013, Week 4 June 2013, Week 3 June 2013, Week 2 June 2013, Week 1 May 2013, Week 5 May 2013, Week 4 May 2013, Week 3 May 2013, Week 2 May 2013, Week 1 April 2013, Week 5 April 2013, Week 4 April 2013, Week 3 April 2013, Week 2 April 2013, Week 1 March 2013, Week 5 March 2013, Week 4 March 2013, Week 3 March 2013, Week 2 March 2013, Week 1 February 2013, Week 4 February 2013, Week 3 February 2013, Week 2 February 2013, Week 1 January 2013, Week 5 January 2013, Week 3 January 2013, Week 2 January 2013, Week 1 December 2012, Week 5 December 2012, Week 4 December 2012, Week 3 December 2012, Week 2 December 2012, Week 1 November 2012, Week 5 November 2012, Week 3 November 2012, Week 2 November 2012, Week 1 October 2012, Week 5 October 2012, Week 4 October 2012, Week 3 October 2012, Week 2 October 2012, Week 1 September 2012, Week 5 September 2012, Week 4 September 2012, Week 3 September 2012, Week 2 September 2012, Week 1 August 2012, Week 5 August 2012, Week 4 August 2012, Week 3 August 2012, Week 2 August 2012, Week 1 July 2012, Week 5 July 2012, Week 4 July 2012, Week 3 July 2012, Week 2 July 2012, Week 1 June 2012, Week 5 June 2012, Week 4 June 2012, Week 3 June 2012, Week 2 June 2012, Week 1 May 2012, Week 5 May 2012, Week 4 May 2012, Week 3 May 2012, Week 2 May 2012, Week 1 April 2012, Week 5 April 2012, Week 4 April 2012, Week 3 April 2012, Week 2 April 2012, Week 1 March 2012, Week 5 March 2012, Week 4 March 2012, Week 3 March 2012, Week 2 March 2012, Week 1 February 2012, Week 5 February 2012, Week 4 February 2012, Week 3 February 2012, Week 2 February 2012, Week 1 January 2012, Week 5 January 2012, Week 4 January 2012, Week 3 January 2012, Week 2 January 2012, Week 1 December 2011, Week 5 December 2011, Week 4 December 2011, Week 3 December 2011, Week 2 December 2011, Week 1 November 2011, Week 5 November 2011, Week 4 November 2011, Week 3 November 2011, Week 2 November 2011, Week 1 October 2011, Week 5 October 2011, Week 4 October 2011, Week 3 October 2011, Week 2 October 2011, Week 1 September 2011, Week 5 September 2011, Week 4 September 2011, Week 3 September 2011, Week 2 September 2011, Week 1 August 2011, Week 5 August 2011, Week 4 August 2011, Week 3 August 2011, Week 2 August 2011, Week 1 July 2011, Week 5 July 2011, Week 4 July 2011, Week 3 July 2011, Week 2 July 2011, Week 1 June 2011, Week 5 June 2011, Week 4 June 2011, Week 3 June 2011, Week 2 June 2011, Week 1 May 2011, Week 5 May 2011, Week 4 May 2011, Week 3 May 2011, Week 2 May 2011, Week 1 April 2011, Week 5 April 2011, Week 4 April 2011, Week 3 April 2011, Week 2 April 2011, Week 1 March 2011, Week 5 March 2011, Week 4 March 2011, Week 3 March 2011, Week 2 March 2011, Week 1 February 2011, Week 4 February 2011, Week 3 February 2011, Week 2 February 2011, Week 1 January 2011, Week 5 January 2011, Week 4 January 2011, Week 3 January 2011, Week 2 January 2011, Week 1 December 2010, Week 5 December 2010, Week 4 December 2010, Week 3 December 2010, Week 2 December 2010, Week 1 November 2010, Week 5 November 2010, Week 4 November 2010, Week 3 November 2010, Week 2 November 2010, Week 1 October 2010, Week 5 October 2010, Week 4 October 2010, Week 3 October 2010, Week 2 October 2010, Week 1 September 2010, Week 5 September 2010, Week 4 September 2010, Week 3 September 2010, Week 2 September 2010, Week 1 August 2010, Week 5 August 2010, Week 4 August 2010, Week 3 August 2010, Week 2 August 2010, Week 1 July 2010, Week 5 July 2010, Week 4 July 2010, Week 3 July 2010, Week 2 July 2010, Week 1 June 2010, Week 5 June 2010, Week 4 June 2010, Week 3 June 2010, Week 2 June 2010, Week 1 May 2010, Week 5 May 2010, Week 4 May 2010, Week 3 May 2010, Week 2 May 2010, Week 1 April 2010, Week 5 April 2010, Week 4 April 2010, Week 3 April 2010, Week 2 April 2010, Week 1 March 2010, Week 5 March 2010, Week 4 March 2010, Week 3 March 2010, Week 2 March 2010, Week 1 February 2010, Week 4 February 2010, Week 3 February 2010, Week 2 February 2010, Week 1 January 2010, Week 5 January 2010, Week 4 January 2010, Week 3 January 2010, Week 2 January 2010, Week 1 December 2009, Week 5 December 2009, Week 4 December 2009, Week 3 December 2009, Week 2 December 2009, Week 1 November 2009, Week 5 November 2009, Week 4 November 2009, Week 3 November 2009, Week 2 November 2009, Week 1 October 2009, Week 5 October 2009, Week 4 October 2009, Week 3 October 2009, Week 2 October 2009, Week 1 September 2009, Week 5 September 2009, Week 4 September 2009, Week 3 September 2009, Week 2 September 2009, Week 1 August 2009, Week 5 August 2009, Week 4 August 2009, Week 3 August 2009, Week 2 August 2009, Week 1 July 2009, Week 5 July 2009, Week 4 July 2009, Week 3 July 2009, Week 2 July 2009, Week 1 June 2009, Week 5 June 2009, Week 4 June 2009, Week 3 June 2009, Week 2 June 2009, Week 1 May 2009, Week 5 May 2009, Week 4 May 2009, Week 3 May 2009, Week 2 May 2009, Week 1 April 2009, Week 5 April 2009, Week 4 April 2009, Week 3 April 2009, Week 2 April 2009, Week 1 March 2009, Week 5 March 2009, Week 4 March 2009, Week 3 March 2009, Week 2 March 2009, Week 1 February 2009, Week 4 February 2009, Week 3 February 2009, Week 2 February 2009, Week 1 January 2009, Week 5 January 2009, Week 4 January 2009, Week 3 January 2009, Week 2 January 2009, Week 1 December 2008, Week 5 December 2008, Week 4 December 2008, Week 3 December 2008, Week 2 December 2008, Week 1 November 2008, Week 5 November 2008, Week 4 November 2008, Week 3 November 2008, Week 2 November 2008, Week 1 October 2008, Week 5 October 2008, Week 4 October 2008, Week 3 October 2008, Week 2 October 2008, Week 1 September 2008, Week 5 September 2008, Week 4 September 2008, Week 3 September 2008, Week 2 September 2008, Week 1 August 2008, Week 5 August 2008, Week 4 August 2008, Week 3 August 2008, Week 2 August 2008, Week 1 July 2008, Week 5 July 2008, Week 4 July 2008, Week 3 July 2008, Week 2 July 2008, Week 1 June 2008, Week 5 June 2008, Week 4 June 2008, Week 3 June 2008, Week 2 June 2008, Week 1 May 2008, Week 5 May 2008, Week 4 May 2008, Week 3 May 2008, Week 2 May 2008, Week 1 April 2008, Week 5 April 2008, Week 4 April 2008, Week 3 April 2008, Week 2 April 2008, Week 1 March 2008, Week 5 March 2008, Week 4 March 2008, Week 3 March 2008, Week 2 March 2008, Week 1 February 2008, Week 5 February 2008, Week 4 February 2008, Week 3 February 2008, Week 2 February 2008, Week 1 January 2008, Week 5 January 2008, Week 4 January 2008, Week 3 January 2008, Week 2 January 2008, Week 1 December 2007, Week 5 December 2007, Week 4 December 2007, Week 3 December 2007, Week 2 December 2007, Week 1 November 2007, Week 5 November 2007, Week 4 November 2007, Week 3 November 2007, Week 2 November 2007, Week 1 October 2007, Week 5 October 2007, Week 4 October 2007, Week 3 October 2007, Week 2 October 2007, Week 1 September 2007, Week 5 September 2007, Week 4 September 2007, Week 3 September 2007, Week 2 September 2007, Week 1 August 2007, Week 5 August 2007, Week 4 August 2007, Week 3 August 2007, Week 2 August 2007, Week 1 July 2007, Week 5 July 2007, Week 4 July 2007, Week 3 July 2007, Week 2 July 2007, Week 1 June 2007, Week 5 June 2007, Week 4 June 2007, Week 3 June 2007, Week 2 June 2007, Week 1 May 2007, Week 5 May 2007, Week 4 May 2007, Week 3 May 2007, Week 2 May 2007, Week 1 April 2007, Week 5 April 2007, Week 4 April 2007, Week 3 April 2007, Week 2 April 2007, Week 1 March 2007, Week 5 March 2007, Week 4 March 2007, Week 3 March 2007, Week 2 March 2007, Week 1 February 2007, Week 4 February 2007, Week 3 February 2007, Week 2 February 2007, Week 1 January 2007, Week 5 January 2007, Week 4 January 2007, Week 3 January 2007, Week 2 January 2007, Week 1 December 2006, Week 5 December 2006, Week 4 December 2006, Week 3 December 2006, Week 2 December 2006, Week 1 November 2006, Week 5 November 2006, Week 4 November 2006, Week 3 November 2006, Week 2 November 2006, Week 1 October 2006, Week 5 October 2006, Week 4 October 2006, Week 3 October 2006, Week 2 October 2006, Week 1 September 2006, Week 5 September 2006, Week 4 September 2006, Week 3 September 2006, Week 2 September 2006, Week 1 August 2006, Week 5 August 2006, Week 4 August 2006, Week 3 August 2006, Week 2 August 2006, Week 1 July 2006, Week 5 July 2006, Week 4 July 2006, Week 3 July 2006, Week 2 July 2006, Week 1 June 2006, Week 5 June 2006, Week 4 June 2006, Week 3 June 2006, Week 2 June 2006, Week 1 May 2006, Week 5 May 2006, Week 4 May 2006, Week 3 May 2006, Week 2 May 2006, Week 1 April 2006, Week 5 April 2006, Week 4 April 2006, Week 3 April 2006, Week 2 April 2006, Week 1 March 2006, Week 5 March 2006, Week 4 March 2006, Week 3 March 2006, Week 2 March 2006, Week 1 February 2006, Week 4 February 2006, Week 3 February 2006, Week 2 February 2006, Week 1 January 2006, Week 5 January 2006, Week 4 January 2006, Week 3 January 2006, Week 2 January 2006, Week 1 December 2005, Week 5 December 2005, Week 4 December 2005, Week 3 December 2005, Week 2 December 2005, Week 1 November 2005, Week 5 November 2005, Week 4 November 2005, Week 3 November 2005, Week 2 November 2005, Week 1 October 2005, Week 5 October 2005, Week 4 October 2005, Week 3 October 2005, Week 2 October 2005, Week 1 September 2005, Week 5 September 2005, Week 4 September 2005, Week 3 September 2005, Week 2 September 2005, Week 1 August 2005, Week 5 August 2005, Week 4 August 2005, Week 3 August 2005, Week 2 August 2005, Week 1 July 2005, Week 5 July 2005, Week 4 July 2005, Week 3 July 2005, Week 2 July 2005, Week 1 June 2005, Week 5 June 2005, Week 4 June 2005, Week 3 June 2005, Week 2 June 2005, Week 1 May 2005, Week 5 May 2005, Week 4 May 2005, Week 3 May 2005, Week 2 May 2005, Week 1 April 2005, Week 5 April 2005, Week 4 April 2005, Week 3 April 2005, Week 2 April 2005, Week 1 March 2005, Week 5 March 2005, Week 4 March 2005, Week 3 March 2005, Week 2 March 2005, Week 1 February 2005, Week 4 February 2005, Week 3 February 2005, Week 2 February 2005, Week 1 January 2005, Week 5 January 2005, Week 4 January 2005, Week 3 January 2005, Week 2 January 2005, Week 1 December 2004, Week 5 December 2004, Week 4 December 2004, Week 3 December 2004, Week 2 December 2004, Week 1 November 2004, Week 5 November 2004, Week 4 November 2004, Week 3 November 2004, Week 2 November 2004, Week 1 October 2004, Week 5 October 2004, Week 4 October 2004, Week 3 October 2004, Week 2 October 2004, Week 1 September 2004, Week 5 September 2004, Week 4 September 2004, Week 3 September 2004, Week 2 September 2004, Week 1 August 2004, Week 5 August 2004, Week 4 August 2004, Week 3 August 2004, Week 2 August 2004, Week 1 July 2004, Week 5 July 2004, Week 4 July 2004, Week 3 July 2004, Week 2 July 2004, Week 1 June 2004, Week 5 June 2004, Week 4 June 2004, Week 3 June 2004, Week 2 June 2004, Week 1 May 2004, Week 5 May 2004, Week 4 May 2004, Week 3 May 2004, Week 2 May 2004, Week 1 April 2004, Week 5 April 2004, Week 4 April 2004, Week 3 April 2004, Week 2 April 2004, Week 1 March 2004, Week 5 March 2004, Week 4 March 2004, Week 3 March 2004, Week 2 March 2004, Week 1 February 2004, Week 5 February 2004, Week 4 February 2004, Week 3 February 2004, Week 2 February 2004, Week 1 January 2004, Week 5 January 2004, Week 4 January 2004, Week 3 January 2004, Week 2 January 2004, Week 1 December 2003, Week 5 December 2003, Week 4 December 2003, Week 3 December 2003, Week 2 December 2003, Week 1 November 2003, Week 5 November 2003, Week 4 November 2003, Week 3 November 2003, Week 2 November 2003, Week 1 October 2003, Week 5 October 2003, Week 4 October 2003, Week 3 October 2003, Week 2 October 2003, Week 1 September 2003, Week 5 September 2003, Week 4 September 2003, Week 3 September 2003, Week 2 September 2003, Week 1 August 2003, Week 5 August 2003, Week 4 August 2003, Week 3 August 2003, Week 2 August 2003, Week 1 July 2003, Week 5 July 2003, Week 4 July 2003, Week 3 July 2003, Week 2 July 2003, Week 1 June 2003, Week 5 June 2003, Week 4 June 2003, Week 3 June 2003, Week 2 June 2003, Week 1 May 2003, Week 5 May 2003, Week 4 May 2003, Week 3 May 2003, Week 2 May 2003, Week 1 April 2003, Week 5 April 2003, Week 4 April 2003, Week 3 April 2003, Week 2 April 2003, Week 1 March 2003, Week 5 March 2003, Week 4 March 2003, Week 3 March 2003, Week 2 March 2003, Week 1 February 2003, Week 4 February 2003, Week 3 February 2003, Week 2 February 2003, Week 1 January 2003, Week 5 January 2003, Week 4 January 2003, Week 3 January 2003, Week 2 January 2003, Week 1 December 2002, Week 5 December 2002, Week 4 December 2002, Week 3 December 2002, Week 2 December 2002, Week 1 November 2002, Week 5 November 2002, Week 4 November 2002, Week 3 November 2002, Week 2 November 2002, Week 1 October 2002, Week 5 October 2002, Week 4 October 2002, Week 3 October 2002, Week 2 October 2002, Week 1 September 2002, Week 5 September 2002, Week 4 September 2002, Week 3 September 2002, Week 2 September 2002, Week 1 August 2002, Week 5 August 2002, Week 4 August 2002, Week 3 August 2002, Week 2 August 2002, Week 1 July 2002, Week 5 July 2002, Week 4 July 2002, Week 3 July 2002, Week 2 July 2002, Week 1 June 2002, Week 5 June 2002, Week 4 June 2002, Week 3 June 2002, Week 2 June 2002, Week 1 May 2002, Week 5 May 2002, Week 4 May 2002, Week 3 May 2002, Week 2 May 2002, Week 1 April 2002, Week 5 April 2002, Week 4 April 2002, Week 3 April 2002, Week 2 April 2002, Week 1 March 2002, Week 5 March 2002, Week 4 March 2002, Week 3 March 2002, Week 2 March 2002, Week 1 February 2002, Week 4 February 2002, Week 3 February 2002, Week 2 February 2002, Week 1 January 2002, Week 5 January 2002, Week 4 January 2002, Week 3 January 2002, Week 2 January 2002, Week 1 December 2001, Week 5 December 2001, Week 4 December 2001, Week 3 December 2001, Week 2 December 2001, Week 1 November 2001, Week 5 November 2001, Week 4 November 2001, Week 3 November 2001, Week 2 November 2001, Week 1 October 2001, Week 5 October 2001, Week 4 October 2001, Week 3 October 2001, Week 2 October 2001, Week 1 September 2001, Week 5 September 2001, Week 4 September 2001, Week 3 September 2001, Week 2 September 2001, Week 1 August 2001, Week 5 August 2001, Week 4 August 2001, Week 3 August 2001, Week 2 August 2001, Week 1 July 2001, Week 5 July 2001, Week 4 July 2001, Week 3 July 2001, Week 2 July 2001, Week 1 June 2001, Week 5 June 2001, Week 4 June 2001, Week 3 June 2001, Week 2 June 2001, Week 1 May 2001, Week 5 May 2001, Week 4 May 2001, Week 3 May 2001, Week 2 May 2001, Week 1 April 2001, Week 5 April 2001, Week 4 April 2001, Week 3 April 2001, Week 2 April 2001, Week 1 March 2001, Week 5 March 2001, Week 4 March 2001, Week 3 March 2001, Week 2 March 2001, Week 1 February 2001, Week 4 February 2001, Week 3 February 2001, Week 2 February 2001, Week 1 January 2001, Week 5 January 2001, Week 4 January 2001, Week 3 January 2001, Week 2 January 2001, Week 1 December 2000, Week 5 December 2000, Week 4 December 2000, Week 3 December 2000, Week 2 December 2000, Week 1 November 2000, Week 5 November 2000, Week 4 November 2000, Week 3 November 2000, Week 2 November 2000, Week 1 October 2000, Week 5 October 2000, Week 4 October 2000, Week 3 October 2000, Week 2 October 2000, Week 1 September 2000, Week 5 September 2000, Week 4 September 2000, Week 3 September 2000, Week 2 September 2000, Week 1 August 2000, Week 5 August 2000, Week 4 August 2000, Week 3 August 2000, Week 2 August 2000, Week 1 July 2000, Week 5 July 2000, Week 4 July 2000, Week 3 July 2000, Week 2 July 2000, Week 1 June 2000, Week 5 June 2000, Week 4 June 2000, Week 3 June 2000, Week 2 June 2000, Week 1 May 2000, Week 5 May 2000, Week 4 May 2000, Week 3 May 2000, Week 2 May 2000, Week 1 April 2000, Week 5 April 2000, Week 4 April 2000, Week 3 April 2000, Week 2 April 2000, Week 1 March 2000, Week 5 March 2000, Week 4 March 2000, Week 3 March 2000, Week 2 March 2000, Week 1 February 2000, Week 5 February 2000, Week 4 February 2000, Week 3 February 2000, Week 2 February 2000, Week 1 January 2000, Week 5 January 2000, Week 4 January 2000, Week 3 January 2000, Week 2 January 2000, Week 1 December 1999, Week 5 December 1999, Week 4 December 1999, Week 3 December 1999, Week 2 December 1999, Week 1 November 1999, Week 5 November 1999, Week 4 November 1999, Week 3 November 1999, Week 2 November 1999, Week 1 October 1999, Week 5 October 1999, Week 4 October 1999, Week 3 October 1999, Week 2 October 1999, Week 1 September 1999, Week 5 September 1999, Week 4 September 1999, Week 3 September 1999, Week 2 September 1999, Week 1 August 1999, Week 5 August 1999, Week 4 August 1999, Week 3 August 1999, Week 2 August 1999, Week 1 July 1999, Week 5 July 1999, Week 4 July 1999, Week 3 July 1999, Week 2 July 1999, Week 1 June 1999, Week 5 June 1999, Week 4 June 1999, Week 3 June 1999, Week 2 June 1999, Week 1 May 1999, Week 5 May 1999, Week 4 May 1999, Week 3 May 1999, Week 2 May 1999, Week 1 April 1999, Week 5 April 1999, Week 4 April 1999, Week 3 April 1999, Week 2 April 1999, Week 1 March 1999, Week 5 March 1999, Week 4 March 1999, Week 3 March 1999, Week 2 March 1999, Week 1 February 1999, Week 4 February 1999, Week 3 February 1999, Week 2 February 1999, Week 1 January 1999, Week 5 January 1999, Week 4 January 1999, Week 3 January 1999, Week 2 January 1999, Week 1 December 1998, Week 5 December 1998, Week 4 December 1998, Week 3 December 1998, Week 2 December 1998, Week 1 November 1998, Week 5 November 1998, Week 4 November 1998, Week 3 November 1998, Week 2 November 1998, Week 1 October 1998, Week 5 October 1998, Week 4 October 1998, Week 3 October 1998, Week 2 October 1998, Week 1 September 1998, Week 5 September 1998, Week 4 September 1998, Week 3 September 1998, Week 2 September 1998, Week 1 August 1998, Week 5 August 1998, Week 4 August 1998, Week 3 August 1998, Week 2 August 1998, Week 1 July 1998, Week 5 July 1998, Week 4 July 1998, Week 3 July 1998, Week 2 July 1998, Week 1 June 1998, Week 5 June 1998, Week 4 June 1998, Week 3 June 1998, Week 2 June 1998, Week 1 May 1998, Week 5 May 1998, Week 4 May 1998, Week 3 May 1998, Week 2 May 1998, Week 1 April 1998, Week 5 April 1998, Week 4 April 1998, Week 3 April 1998, Week 2 April 1998, Week 1 March 1998, Week 5 March 1998, Week 4 March 1998, Week 3 March 1998, Week 2 March 1998, Week 1 February 1998, Week 5 February 1998, Week 4 February 1998, Week 3 February 1998, Week 2 February 1998, Week 1 January 1998, Week 5 January 1998, Week 4 January 1998, Week 3 January 1998, Week 2 January 1998, Week 1 December 1997, Week 5 December 1997, Week 4 December 1997, Week 3 December 1997, Week 2 December 1997, Week 1 November 1997, Week 5 November 1997, Week 4 November 1997, Week 3 November 1997, Week 2 November 1997, Week 1 October 1997, Week 5 October 1997, Week 4 October 1997, Week 3 October 1997, Week 2 October 1997, Week 1 September 1997, Week 5 September 1997, Week 4 September 1997, Week 3 September 1997, Week 2 September 1997, Week 1 August 1997, Week 5 August 1997, Week 4 August 1997, Week 3 August 1997, Week 2 August 1997, Week 1 July 1997, Week 5 July 1997, Week 4 July 1997, Week 3 July 1997, Week 2 July 1997, Week 1 June 1997, Week 5 June 1997, Week 4 June 1997, Week 3 June 1997, Week 2 June 1997, Week 1 May 1997, Week 5 May 1997, Week 4 May 1997, Week 3 May 1997, Week 2 May 1997, Week 1 April 1997, Week 5 April 1997, Week 4 April 1997, Week 3 April 1997, Week 2 April 1997, Week 1 March 1997, Week 5 March 1997, Week 4 March 1997, Week 3 March 1997, Week 2 March 1997, Week 1 February 1997, Week 5 February 1997, Week 4 February 1997, Week 3 February 1997, Week 2 February 1997, Week 1 January 1997, Week 5 January 1997, Week 4 January 1997, Week 3 January 1997, Week 2 January 1997, Week 1 December 1996, Week 5 December 1996, Week 4 December 1996, Week 3 December 1996, Week 2 December 1996, Week 1 November 1996, Week 5 November 1996, Week 4 November 1996, Week 3 November 1996, Week 2 November 1996, Week 1 October 1996, Week 5 October 1996, Week 4 October 1996, Week 3 October 1996, Week 2 October 1996, Week 1 September 1996, Week 5 September 1996, Week 4 September 1996, Week 3 September 1996, Week 2 September 1996, Week 1 August 1996, Week 5 August 1996, Week 4 August 1996, Week 3 August 1996, Week 2 August 1996, Week 1 July 1996, Week 5 July 1996, Week 4 July 1996, Week 3 July 1996, Week 2 July 1996, Week 1 June 1996, Week 5 June 1996, Week 4 June 1996, Week 3 June 1996, Week 2 June 1996, Week 1 May 1996, Week 5 May 1996, Week 4 May 1996, Week 3 May 1996, Week 2 May 1996, Week 1 April 1996, Week 5 April 1996, Week 4 April 1996, Week 3 April 1996, Week 2 April 1996, Week 1 March 1996, Week 5 March 1996, Week 4 March 1996, Week 3 March 1996, Week 2 March 1996, Week 1 February 1996, Week 5 February 1996, Week 4 February 1996, Week 3 February 1996, Week 2 February 1996, Week 1 January 1996, Week 5 January 1996, Week 4 January 1996, Week 3 January 1996, Week 2 January 1996, Week 1 December 1995, Week 5 December 1995, Week 4 December 1995, Week 3 December 1995, Week 2 December 1995, Week 1 November 1995, Week 5 November 1995, Week 4 November 1995, Week 3 November 1995, Week 2 November 1995, Week 1 October 1995, Week 5 October 1995, Week 4 October 1995, Week 3 October 1995, Week 2 October 1995, Week 1 September 1995, Week 5 September 1995, Week 4 September 1995, Week 3 September 1995, Week 2 September 1995, Week 1 August 1995, Week 5 August 1995, Week 4 August 1995, Week 3 August 1995, Week 2 August 1995, Week 1 July 1995, Week 5 July 1995, Week 4 July 1995, Week 3 July 1995, Week 2 July 1995, Week 1 June 1995, Week 5 June 1995, Week 4 June 1995, Week 3 June 1995, Week 2 June 1995, Week 1 May 1995, Week 5 May 1995, Week 4 May 1995, Week 3 May 1995, Week 2 May 1995, Week 1 April 1995, Week 5 April 1995, Week 4 April 1995, Week 3 April 1995, Week 2 April 1995, Week 1 March 1995, Week 5 March 1995, Week 4 March 1995, Week 3 March 1995, Week 2 March 1995, Week 1 February 1995, Week 4 February 1995, Week 3 February 1995, Week 2 February 1995, Week 1 January 1995, Week 5 January 1995, Week 4 January 1995, Week 3 January 1995, Week 2 January 1995, Week 1 December 1994, Week 5 December 1994, Week 4 December 1994, Week 3 December 1994, Week 2 December 1994, Week 1 November 1994, Week 5 November 1994, Week 4 November 1994, Week 3 November 1994, Week 2 November 1994, Week 1 October 1994, Week 5 October 1994, Week 4 October 1994, Week 3 October 1994, Week 2 October 1994, Week 1 September 1994, Week 5 September 1994, Week 4 September 1994, Week 3 September 1994, Week 2 September 1994, Week 1 August 1994, Week 5 August 1994, Week 4 August 1994, Week 3 August 1994, Week 2 August 1994, Week 1 July 1994, Week 5 July 1994, Week 4 July 1994, Week 3 July 1994, Week 2 July 1994, Week 1 June 1994, Week 5 June 1994, Week 4 June 1994, Week 3 June 1994, Week 2 June 1994, Week 1 May 1994, Week 5 May 1994, Week 4 May 1994, Week 3 May 1994, Week 2 May 1994, Week 1 April 1994, Week 5 April 1994, Week 4 April 1994, Week 3 April 1994, Week 2 April 1994, Week 1 March 1994, Week 5 March 1994, Week 4 March 1994, Week 3 March 1994, Week 2 March 1994, Week 1 February 1994, Week 4 February 1994, Week 3 February 1994, Week 2 February 1994, Week 1 February 1994 January 1994 December 1993 November 1993
|
|
|
|