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Excellent explanation, Ivan. I can see why you were
such a good teacher. Carole
--- Ivan M Suzman <[log in to unmask]> wrote:
> ^^^^^^ WARM GREETINGS FROM ^^^^^^^^^^^^ :-)
> Ivan Suzman 49/39/36 [log in to unmask]
> :-)
> Portland, Maine land of lighthouses 52
> deg. F :-)
>
********************************************************************
> Adapted from: Human Anatomy and Physiology
> Benjamin/Cummings
> by Elaine N. Marieb, 1992
>
> Revised by Ivan Suzman.
>
> Dear list members,
>
> I hope the following will assist all of you in
> understanding how
> levodopa reaches the brain.
>
>
> The blood-brain barrier is a protective anatomical
> arrangement
> that helps the brain's environment to remain stable.
> No other
> organ is so absolutely dependent on a constant
> internal chemistry.
> In other parts of the body, extra-cellular
> concentrations of
> hormones, amino acids (building blocks of protein),
> and ions
> are in a state of flux, particularly after eating or
> exercising.
>
> If the brain were exposed to such chemical
> variations,.its
> nerve cells would fire uncontrollably. This is in
> part because
> some hormones and amino acids serve as
> neurotransmitters,
> and some ions (particularly potassium) modify the
> neuronal
> firing.
>
> Blood-carried substances within the brain's
> capillaries are
> separated from the tissue of the brain by (1) the
> structure of the
> capillary walls ; (2) a relatively thick basal
> lamina on the external
> surfaces of these capillaries, and (3) the structure
> of the astrocytes,
> which are star-shaped projections from the neurons
> of the brain
> tissues to the capillaries.
>
> The relative impermeability of brain capillaries
> results in a
> virtually complete blood-brain barrier.
>
> The blood-brain barrier is selective. A point of
> great importance in
> Parkinson's Disease, is that essential amino acids
> like
> phenylalanine (which is the important ingredient in
> Sinemet),
> glucose, and some electrolytes diffuse into the
> brain.
> Blood-borne wastes such as urea, as well as large
> proteins
> are prevented from entering the brain tissue. Small
> non-essential
> amino acids and potassium ions are also prevented
> from
> entering the brain.
>
> The blood-brain barrier is ineffective against fats,
> fatty acids,
> oxygen and carbon dioxide. Fat-soluble
> molecules such as blood-borne alcohol, nicotine,
> anesthetics,
> and THC (from marijuana) easily pass by diffusion to
> the
> brain. In some areas of the brain, the blood-brain
> barrier is
> either partial or absent. In these areas, blood-born
> molecules
> gain easy access to brain tissue. One such area is
> the
> vomiting sensor of the brain stem.
>
> Another is the hypothalamus which is extremely
> important in
> PD. Hydration (water balance), body temperature and
> many
> metabolic activities are regulated here. The lack of
> a blood-
> brain barrier in these areas allows "quick-testing"
> of the
> composition of the blood.
>
> The blood-brain barrier in infants and fetuses is
> incomplete.
> Biochemical injury to the brain by toxic exposure is
> more
> likely in children than in adults. Traumatic injury
> to the brain
> may cause localized breaches in the blood-brain
> barrier.
> Medical management of the biochemistry of the brain
> can
> be achieved in some cases by infusing drugs through
> gateways in the blood-brain barrier. The drug
> manitol is one
> that is used to create these gateways.
>
> October 23, 1999 Portland, Maine :-)
>
=====
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December 1996, Week 3 December 1996, Week 2 December 1996, Week 1 November 1996, Week 5 November 1996, Week 4 November 1996, Week 3 November 1996, Week 2 November 1996, Week 1 October 1996, Week 5 October 1996, Week 4 October 1996, Week 3 October 1996, Week 2 October 1996, Week 1 September 1996, Week 5 September 1996, Week 4 September 1996, Week 3 September 1996, Week 2 September 1996, Week 1 August 1996, Week 5 August 1996, Week 4 August 1996, Week 3 August 1996, Week 2 August 1996, Week 1 July 1996, Week 5 July 1996, Week 4 July 1996, Week 3 July 1996, Week 2 July 1996, Week 1 June 1996, Week 5 June 1996, Week 4 June 1996, Week 3 June 1996, Week 2 June 1996, Week 1 May 1996, Week 5 May 1996, Week 4 May 1996, Week 3 May 1996, Week 2 May 1996, Week 1 April 1996, Week 5 April 1996, Week 4 April 1996, Week 3 April 1996, Week 2 April 1996, Week 1 March 1996, Week 5 March 1996, Week 4 March 1996, Week 3 March 1996, Week 2 March 1996, Week 1 February 1996, Week 5 February 1996, Week 4 February 1996, Week 3 February 1996, Week 2 February 1996, Week 1 January 1996, Week 5 January 1996, Week 4 January 1996, Week 3 January 1996, Week 2 January 1996, Week 1 December 1995, Week 5 December 1995, Week 4 December 1995, Week 3 December 1995, Week 2 December 1995, Week 1 November 1995, Week 5 November 1995, Week 4 November 1995, Week 3 November 1995, Week 2 November 1995, Week 1 October 1995, Week 5 October 1995, Week 4 October 1995, Week 3 October 1995, Week 2 October 1995, Week 1 September 1995, Week 5 September 1995, Week 4 September 1995, Week 3 September 1995, Week 2 September 1995, Week 1 August 1995, Week 5 August 1995, Week 4 August 1995, Week 3 August 1995, Week 2 August 1995, Week 1 July 1995, Week 5 July 1995, Week 4 July 1995, Week 3 July 1995, Week 2 July 1995, Week 1 June 1995, Week 5 June 1995, Week 4 June 1995, Week 3 June 1995, Week 2 June 1995, Week 1 May 1995, Week 5 May 1995, Week 4 May 1995, Week 3 May 1995, Week 2 May 1995, Week 1 April 1995, Week 5 April 1995, Week 4 April 1995, Week 3 April 1995, Week 2 April 1995, Week 1 March 1995, Week 5 March 1995, Week 4 March 1995, Week 3 March 1995, Week 2 March 1995, Week 1 February 1995, Week 4 February 1995, Week 3 February 1995, Week 2 February 1995, Week 1 January 1995, Week 5 January 1995, Week 4 January 1995, Week 3 January 1995, Week 2 January 1995, Week 1 December 1994, Week 5 December 1994, Week 4 December 1994, Week 3 December 1994, Week 2 December 1994, Week 1 November 1994, Week 5 November 1994, Week 4 November 1994, Week 3 November 1994, Week 2 November 1994, Week 1 October 1994, Week 5 October 1994, Week 4 October 1994, Week 3 October 1994, Week 2 October 1994, Week 1 September 1994, Week 5 September 1994, Week 4 September 1994, Week 3 September 1994, Week 2 September 1994, Week 1 August 1994, Week 5 August 1994, Week 4 August 1994, Week 3 August 1994, Week 2 August 1994, Week 1 July 1994, Week 5 July 1994, Week 4 July 1994, Week 3 July 1994, Week 2 July 1994, Week 1 June 1994, Week 5 June 1994, Week 4 June 1994, Week 3 June 1994, Week 2 June 1994, Week 1 May 1994, Week 5 May 1994, Week 4 May 1994, Week 3 May 1994, Week 2 May 1994, Week 1 April 1994, Week 5 April 1994, Week 4 April 1994, Week 3 April 1994, Week 2 April 1994, Week 1 March 1994, Week 5 March 1994, Week 4 March 1994, Week 3 March 1994, Week 2 March 1994, Week 1 February 1994, Week 4 February 1994, Week 3 February 1994, Week 2 February 1994, Week 1 February 1994 January 1994 December 1993 November 1993
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