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You may remember that I was going to try Mirtazapine for my tremor. My neurologist had me start slow (1 pill/night for the first three or four nights, then call him to determine what to do next - three pills/day is the normal dose). I started Wednesday night, took one pill and woke up fifteen hours later. No tremor during that period, but there never is a tremor while I sleep. I got up at noon yesterday and felt very tired. It took a couple more hours to wear off - then I was back to normal. It was such a knock out I couldn't put myself through it again. So, I'm back to a constant shaking, but I have some energy again. At the same time I don't want to discourage anyone from trying it. Very few meds work for me the way they are supposed to. Joan 58/48