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Hi janet: Is this saying what I think it is? I KNEW the 60's had to be right about SOMETHING. Carole --- janet paterson <[log in to unmask]> wrote: > Cannabis in movement disorders. > > Central cannabinoid receptors are densely located in the > output nuclei > of the basal ganglia (globus pallidus, substantia nigra > pars > reticulata), suggesting their involvement in the > regulation of motor > activity. > > Furthermore, there is evidence that endogenous > cannabinoid transmission > plays a role in the manipulation of other transmitter > systems within the > basal ganglia by increasing GABAergic transmission, > inhibiting glutamate > release and affecting dopaminergic uptake. > > Most hyperkinetic and hypokinetic movement disorders are > caused by a > dysfunction of basal ganglia-thalamo-cortical loops. > > It has been suggested that an endogenous cannabinoid tone > participates > in the control of movements and, therefore, the central > cannabinoid > system might play a role in the pathophysiology of these > diseases. > > During the last years in humans a limited number of > clinical trials > demonstrated that cannabinoids might be useful in the > treatment of > movement disorders. > > Despite the lack of controlled studies there is evidence > that > cannabinoids are of therapeutic value in the treatment of > tics in > Tourette syndrome, the reduction of levodopa-induced > dyskinesia in > Parkinson's > disease and some forms of tremor and dystonia. > > It can be speculated that cannabinoid antagonists might > be useful in the > treatment of chorea in > Huntington's disease and hypokinetic parkinsonian > syndromes. > > > Muller-Vahl KR, Kolbe H, Schneider U, Emrich HM > Department of Clinical Psychiatry and Psychotherapy, > Medical School > Hannover, Germany. [log in to unmask] > Forsch Komplementarmed 1999 Oct;6 Suppl 3:23-7 > PMID: 10627163, UI: 20088049 > > <http://www.ncbi.nlm.nih.gov/PubMed> > __________________________________________________ Do You Yahoo!? Talk to your friends online with Yahoo! Messenger. http://im.yahoo.com