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The pre-approval process of the FDA is supposedly designed to uncover any problems such as negative or side reactions arising from the use of any drug. Michel Carole Hercun wrote: > Let me also add that while Sinemet has been around forever > and the long-term side-effects are known, ALL the > side-effects of the newer drugs will only be discovered > through trial and error and testing on larger populations > of human guinea pigs (PWPs like you and me.)