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ive been on comtan a month but just stopped it. i was teary, weak, constipated, ringing iin my ears--taking 6/day each with a sinemet 25/100. i did have the same problem with eldepryl and mirrapex so I MIGHT JUST BE EXTRA SENSITIVE. i truly would not want to discourage anyone from trying it; just wanted to give you a response. also i slept all the time and felt "in a fog". good luck. nan