In what stage does the drooling start? -----Original Message----- From: ROBERT A MARTONE <[log in to unmask]> To: [log in to unmask] <[log in to unmask]> Date: Friday, January 14, 2000 10:02 AM Subject: Botulinum reduces PD Drooling >Botulinum Toxin A Injection Relieves Drooling In Patients >With Parkinson's Disease > >January 13, 2000 03:33 PM PST > >WESTPORT, Jan 13 (Reuters Health) - Intraparotid injections >of botulinum toxin A can substantially reduce salivary >secretions and drooling in patients with Parkinson's >disease, findings published in the January issue of >Neurology show. > >"[B]otulinum toxin A promises to be a simple and effective >treatment for the common problem of drooling saliva in >chronic neurologic disease," Dr. J. K. C. Tsui, of Vancouver >Hospital and Health Sciences Centre in British Columbia, >Canada, and colleagues say in the report. > >The team conducted a two-phase study designed to assess the >effects of intraparotid botulinum toxin A injections on >drooling in nine patients with Parkinson's disease.Seven >patients were injected with 7.5 mouse units and were >monitored for 8 weeks.At the end of that period, they and >two additional patients were injected with a higher dose of >the drug, 15 units, and were monitored for an additional 8 >weeks. > >The vast majority of patients, 88.9%, "...had objective >reductions in salivary secretion," Dr. Tsui and colleagues >write.Two thirds of the patients demonstrated subjective >reductions in drooling.The two doses used appeared to be >equally effective and were without adverse effects. > >The investigators note that the mean reduction in saliva >secretion was 35% at the end of the study.They suspect that >this percentage actually underestimates the true effects of >the injections, since treatment effects in partial >responders were already beginning to decline by the time of >the final examination.A double-blind study of the >intervention is under way. > >Neurology 2000;54:244-247. > >Copyright 1999 Reuters Limited. All rights reserved. >Republication or redistribution of Reuters content, >including by framing or similar means, is expressly >prohibited without the prior written consent of >Reuters.Reuters shall not be liable for any errors or delays >in the content, or for any actions taken in reliance >thereon. > > >Bob Martone >[log in to unmask] >http://www.kingwoodcable.com/martone/