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John Sell wrote: > > I would appreciate hearing from anyone who are now or have been taking > Comtran for PD. I started Comtan about 6 weeks ago, now take a 200mg tablet 6 times a day. COMT inhibition is evidently not as dramatic as that of Tasmar, but I have reduced Sinemet about 20%, from 1000mg/day to 800mg/day or so, and improved sleep cycle by extending dose interval from 3 hr to 4 hr. Adverse effects if any have been too subtle to identify. Cheers, Joe -- J. R. Bruman (818) 789-3694 3527 Cody Road Sherman Oaks, CA 91403-5013