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Brian, I am sorry I waited so long to answer you. My husband and I are not sure of our time frame , so this is the best we can do. He was started on Selegiline 5 mg 2 x daily and Amantadine 100 2x a day. His disease progressed so added Mirapex in ascending doses was added. He developed what I believe is called "vivid dreams", edema and somnolence. Switched to Requip - not much better.. Then switched to carboidopa-levodopa 12.5 - 50, had nausea and somnolence. All of this with the Selegiline and Amantadine. Now on Selegiline 5 mg 2x a day. Amantidine 100 ( 1 ) once a day. carbidopa-levodopa 5-50 , 3 x a day atenolol 25 mg 1 x daily. multivitiams He is actually better than he was 2 years ago. He does have late onset PD. ( His brother did also) I hope this adds to your data. Nita Brian Collins wrote: > Hello friends I wrote the following e-mail to this group about three weeks > ago, and was disappointed to see it only produced 3 answers. Surely this > fundamental question should be exposed? After all, we know from their previous > letters that many of our contributors are on the receiving end of one or other > of these strategies - I can't believe that they are content to be led off on > a path to potential damage. Here is the story one more time- > > On Fri 17 Dec, Brian Collins wrote: > I have read all the recent e-mails earnestly dealing with moving away from > Sinemet in early Parkinson's, and smiled to myself - a little sadly I must > admit, at the thought of all the discomfort these people are having to put > up with, and even the possibility of real harm. I won't go to the lengths > of quoting all the detailed articles here; suffice it to say that a long > and bitter debate is raging amongst the upper echelons of the neurologist > fraternity, about whether moving away from Sinemet, or avoiding Sinemet for > as long as possible is good or bad for you. Make no mistake - they can't > both be right, and those who are in the wrong camp (The abandon Sinemet > camp if you are not sure where I am coming from) are grimly leading their > patients deeper into the quicksands every day. > > So: You can't trust the neuros ! They cannot all be right ! What can we > do ? Obvoiusly there is no point in me or any of our other amateurs who > write to the list running through our ideas - we could also be as wide of > the mark as the professionals. Well, you might care to keep the following > thoughts handy to try on someone next time the subject comes up.. > > How long do you intend to live ? If you start with that question, and work > back, I think most of you will see that (even with the promise of stem cells) > there is a long road in front of us ( I'm ahead of most of you, but not all, > and it still looks a long road to me. I have already made my Sinemet go > continuously for 20 years- it's easy, anyone can do it, all it takes is a > little common sense. My writing on this subject is available to all, so I > will say no more. What else? Well, I have made the Sinemet go even further, > when it became impossible to use alone at 14 years, and six years on, I have>to take 6 mg of Pergolide to balance the Sinemet, and I'm doing well, but > I am sailing very close to the wind, and the message is: You cannot afford > to play fast and loose with Dopamine agonists. They are, in my view, a lot > more dangerous than Sinemet in their potential side-effects, and must be > treated witth respect. There is a proper place for them, and I think it is > later rather than earlier. > One last warning; The New Agonists cost a LOT more than Sinemet don't > they? When you get your next bit of advice (or read about how great Re-Quip > , Mirapex, etc, etc is) just ask yourself who is paying their wages! > -- > Brian Collins <[log in to unmask]> (59/39/34) > > -- > Brian Collins <[log in to unmask]> (59/39/34)