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Dennis - about your ankles (and mine) ] I should really be asnwering you off list because you seem to be the only person who w as interested in my ankles!!!!!!!! But now that the flurry and excitement about your ankles has died down,(haha) I'll answer your qeeries aboot mine. IT is now several days since i cut down my amantadine to half , and it has not mad any appreciable difference in the left ankle. The right one , which was less affected, is almost back to normal. last time this happened to me was almost 15 years ago. I was then on sinemet and parlodel (bromocriptine) as well. I stopped the parlodel and the anantadine at the same time -- so could not say which for certain had caused the swelliing, The amantadine can cause two other symtoms zssoiated with the swellinig - do you have a kind of network of fine bloodvessels all over the surface of your legs? Giving your legs a sort of purplish tinge. And starting its way at the ankle and working its way a sort of scaley shininess. That is typical of amantadine. I have been taking Mirapex for about 3 or 4 years BeFore that i had been taking permax,, which did cause swelling but no discoloration or shininess. I hope this helps you, Dennis. hilary. Dennis Nestler wrote: > > I thank all of you who wrote the List responding to my inquiring about > swollen ankles and feet and could it be my PD meds. I learned that three > people had swollen ankles. One on Meripex, one on Seligiline, and one on > Amantadine. So it might be hard finding out which of the three meds is > causing the problem. I called my neuro but he did not return my call. Will > try again. > > Dennis > 58/52