Eleanor Noone wrote:
> In a message dated 1/20/00 2:44:11 AM EST, [log in to unmask] writes:
>
> << it is a gift and you should accept it graciously. Using the
> stem cells is NOT killing, it is preserving and enhancing life, as long as
> abortions are not being performed solely to obtain the cells. I can't believe
> that God would want His children to suffer, when it is preventable. >>
>
> I've been trying to figure out
> how to say just what Ken has, but I could never have said it so eloquently.
> Bravo, Ken, and thank you. Eleanor
this investigator ends the abstract with confidence--observe the subject
............................................
[Entrez medline Query]
Other Formats: [Citation Format] [MEDLINE Format]
Links: [107 medline neighbors] [Nat. Biotechnol.]
Order this document
Nat Biotechnol 1999 Jul;17(7):653-9
Induction of a midbrain dopaminergic phenotype in Nurr1-overexpressing
neural stem cells by type 1 astrocytes.
Wagner J, Akerud P, Castro DS, Holm PC, Canals JM, Snyder EY, Perlmann T,
Arenas E
Department of Medical Biochemistry and Biophysics, Karolinska Institute,
Stockholm, Sweden.
The implementation of neural stem cell lines as a source material for brain
tissue transplants is currently limited by the ability to induce specific
neurochemical phenotypes in these cells. Here, we show that coordinated
induction of a ventral mesencephalic dopaminergic phenotype in an
immortalized multipotent neural stem cell line can be achieved in vitro.
This process requires both the overexpression of the nuclear receptor Nurr1
and factors derived from local type 1 astrocytes. Over 80% of cells obtained
by this method demonstrate a phenotype indistinguishable from that of
endogenous dopaminergic neurons. Moreover, this procedure yields an
unlimited number of cells that can engraft in vivo and that may constitute a
useful source material for neuronal replacement in Parkinson's disease.
Comments:
* Comment in: Nat Biotechnol 1999 Jul;17(7):635-6
PMID: 10404157, UI: 99343368
............................................................................................
Ray Strand
mailto:[log in to unmask]
48/47/45?
............................................................................................
...on the edge of the prairie abyss ......................
