Attention: Donald R Boyer Don, I read your inquiry (copy follows) several days ago and assumed a Listmember would suggest you experiment with your drug regimen before considering DBS surgery. I haven't seen While it's true we're all different and I don't know your background or history with Sinemet, it appears your current dosage is quite low. Even if you are hypersensitive to Sinemet a 6 hour dose interval with CR results in serum drug concentration fluctuations that could be improved significantly by dosing more often with smaller amounts. You'd also find titration of increases smoother. I imagine I'll also have DBS surgery too but it'll be a couple of years yet. I have the same symptoms you describe and take about 2200 mgs of Levodopa daily to control them. I don't mind a little dyskinesia but the big stuff beats me up so bad (both mind and body) that I avoid it at all costs. You take 400 mgs for similar symptoms and it's not doing the job. Sure looks from my limited view that you should consider more Sinemet before you elect surgery. Bob Bowling Overland Park, KS -----Original Message----- From: Parkinson's Information Exchange Network [mailto:[log in to unmask]]On Behalf Of Donald R Boyer Sent: Tuesday, January 18, 2000 10:04 AM To: [log in to unmask] Subject: Neurosurgery- DBS I need some help. Where can I find a web site providing decent and timely info on the not yet FDA approved Subthalmic DBS procedures.? I was diagnosed in 1984 and am "officially" classified as Advanced P.D. My medication every 6 hours is a 50\100CR, 1.25 mirapex,and 200 tasmar 3 times a day, amantadine 1 per day at bed. My Down times are more frequent and deeper. I know my meds are not able to do the job. Havealmost no tremors--most of the problem is severe rigidity, some dystonia and dyskinesia. I am considering the subthalmic DBS surgical procedure; I like the idea that it can be reversed but am concerned about bleeding and etc. Any web sites or personal expereiences would be appreciated.