Hi all,
On Mon, 24 Jan 2000, the digest contained:
> ...
> Date: Mon, 24 Jan 2000 11:01:27 -0500
> From: "Hawkins, Darwin" <[log in to unmask]>
> Subject: Re: Sinemet
>
> Would taking one 25/100 every 3 hours be closer to approximating the desired
> effect of one 50/200 every 6 hours? Seems to me it would smooth things out.
> ...
First, let me say (as has been said before) everybody's physi-
ology is different and different medications rarely have the same
effect on two different people. This is especially true with PW-
Ps and Sinemet.
That being said:
25 mg. Carbidopa/100 mg. Levodopa x 8 (every 3 hours) =
200 mg. Carbidopa/800 mg. Levodopa a day
50 mg. Carbidopa/200 mg. Levodopa x 4 (every 6 hours) =
200 mg. Carbidopa/800 mg. Levodopa a day
And, although apparently the same levels of each ingredient is
being used, the regular Sinemet delivery would have "spikes" in
its delivery-graph and effectiveness. Where the CR (controlled
release) version's delivery-graph would be smoother. In theory,
the delivery of the CR is spread out more evenly over its effec-
tive period which results in a more even control of the tremors;
where the non-CR version would result in more control soon after
the dose was taken and less control toward the end of its effec-
tive period.
If I remember correctly, the delivery-graphs for both products
are available at:
http://www.sinemetcr.com/
But, then again, all us PWPs is different ... :-)
Bill--
...who heard that minds are like parachutes -- they function only when open.
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