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Barb, Is it the sugar that gets the Sinemet to "kick" in, or is it just a wee bit of protein, that is present even in a cookie, that does it. I know that sounds strange because too much protein at the wrong time can interfer with the Sinemet doing it's job. I can be so s-l-o-w trying to put the evening meal together, but after sitting down and having a few bites I can feel the change coming. Was it the sugar in the salad dressing? Or trailing after my husband as we walk around a "Flea Market", he stops to get an Italian Sausage Sandwich of which I take two bites, and within minutes I'm "on". Was it the sugar in the bun? I'm very protein sensitive, but if I watch what and when I eat I generally do fairly well. I've also found I do better if I can kind of nibble throughout the day. Sooo - is it a little sugar, a wee bit of protein, or just something to eat that does the trick?! Sharon H 52/44/40