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I am a listener/lurker learning a lot from all of you. My husband (PWP age 46 dx at 36) and I both work full time (we are grateful that he can still do that) and are slowly learning how to cope with things that used to be a jumble, and you have all helped us do this. Thanks He has recently switched agonists, from Mirapex to Requip, and we are discovering a contradictory set of side effects that maybe some of you have experience with. On one hand the Requip makes him very sleepy, something that many people have described, but on the other hand he has been having trouble sleeping at night, he is experiencing something that seems to be between tremors and spasms, and he just can't seem to fall asleep. He has also recently begun using Apromorphine injections as a "rescue device" when he is deeply off and needs to function quickly, mostly in work situations. This is something he does at most once a day and not any time near the evening, so we are not sure if that is or is not effecting his sleeping. What other experiences do any of you have with Apromorphine? Have any of you tried this as a long term pump rather than a rescue injection (this has been mentioned to us as a new idea). Does anyone on the list have any helpful ideas about the sleepless Requip nights? Thanks for the info. Ellie (wife of Reuven 46/36)