Just use the 25/100 pills first, two of them four times a day is the same as what your physician prescribed.. Michel > Ervin McCarthy wrote: > > A question about Sinemet. The doctor gave me a prescription for > 50/200CR four times a day. If I use up the remainder of my Sinemet > 25/100CR two pills to equal the 50/200 C. R will that have the same effect? it may seem like a dumb question but I have a lot of 25/100CR left. Thanks for any information.