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Hi Group - Two weeks ago, just before going on a vacation trip to Florida, I began taking Comtan. Here are my impressions of it so far. The results, while mixed, are generally good. Almost immediately I had to reduce the amount of Sinemet because of increased dyskinesia. Once that was done I noticed a smoother "on / off" transition and better functionality in both the "on" and "off" states. Comtan appears to be a useful addition to Sinemet. On the negative side, response to this medication is (for me, at least) somewhat erratic. Perhaps this will improve with time. Also, I had two episodes of truly violent dyskinesia. I felt as though I was going to virtually explode. Not very pleasant. Hopefully that has passed. Finally, this drug turns urine bright yellow. I am now back on my regular daily schedule. Let's face it, vacation activities - odd mealtimes, sight-seeing, visiting with friends, etc. - are not the norm. I'll write again with any important changes. Ft. Lauderdale and Orlando were great; a Hell of a lot warmer than Rhode Island! Jim Finn