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ATTENTION to all PD research funders! Bulletin ! 31 Jan 2000 bbbPortland, Maine, USA from the desk of a Young-Onset PWP and former Anatomy and Anthropology Professor, Ivan M. Suzman (who is hopinng to catalyze immediate funding ACTION) ********* ************ ************** ******** ******* A DRAMATIC SOLUTION to the riddle of the ORIGINS OF PARKINSON'S DISEASE: Parkinsons Disease Viral Origin Now Likely Dar Joe, In the light of the latest ALS (Lou Gehrig's Disease ) news, I am more than ever convinced that PD is caused by a Human Dopamine Deficieny-causing, or "HDV" virus. I first published the HDV theory on PIEN in early 1999. Do you think many people in the research community saw it , Joe? I think prioritizing a massive and IMMEDIATE investment in funding researched dedicated solely to identifying a proposed HDV virus should be THE top priority of the PD-funding community. Lou Gehrig's Disease DEFINITELY involves a newly-named virus, according to the tremendously exciting press release which the French group released about two weeks ago. Bob Martone and possibly Judith Richards posted this news on PIEN. The newspapers had some mention of it. Robin Elliot was VERY excited when I told him about the virus found in the motor neurons of 17 of 19 spinal cords in the bodies of Lou Gehrig's sufferers (post-morten). Only 1 of 29 non-LGehrig sufferers showed the virus. I would like to see that method applied to PD-cadavers at the world's medical schools. For example, In Johannesburg, we had good records of PD having characterized come of the persons whose cadavers are in the Department of Anatomy at Wiwatersrand University, where I was an Assistant Lecturer and a post-graduate student, when I began my professional career in 1973. Cadavers might be an excellent source for some types of tissue work. Do you have any comments on my theory that PD should be caused by a yet-to-be-discovered virus, "HDV" , or Human Dopamine Deficiency Virus? Anyone from PIEN wish to comment? About one of the CSR citations: Latchman D, Coffin S; Mov Disord 2000;15:9-17: They discuss the use and choice of different viral vectors for delivery of modified genes in treatment of PD. This topic interests me greatly. I wonder if the modified genes can be designed to compensate for the ravages caused by a PD-causing virus. Do they write about the CAUSE of PD, or only about delivery of PD-repairing viral vectors? Does anyone on PIEN know these authors? Please ask them to e-mail me at [log in to unmask], or use this phone numer: 207-797-8488 (USA). Joe, I put a viral theory for PD on the PIEN list at about this time last year. My computer has had a memory crash, and I cannot get to it now. **** Can you, or anyone on PIEN, PLEASE e-mail my viral theory back to me? My desktop won't get me to the PIEN archives at the moment. Does anyojne know if Alison Landes, or Margaret Tuchman Foundation, or PAlliance, PDF, NPF, APDA, PI, NIH (Udall) or any American funding source will make a COMMITMENT to research on the viral origin of PD? Or any of the Canadian or overseas research funding sources? I believe it is a slow virus, possibly like HIV/AIDS. There is some potential to speed the cures for both PD and AIDS ,if enough attention is given to the search for my proposed HDV. A second reference you listed also interests me: Chaudhuri K et al; Mov Disord 2000;15:18-23: Ongoing study since 1995 shows, even after excluding multiple system atrophy (MSA) and progressive supranuclear palsy (PSP), that prevalence of atypical, sporadic, L-dopa-resistant PD is 3- to 4-fold greater among Afro-Caribbean or Indian immigrants to the UK than among the remainder population. Joe, is this discussed in a viral-origin, or only in genetic framework? Demographic factors are relevant. A good example is the demography of post-World War I swine flu-related meningitis, and the appearance of Parkinson's Disease later, as seen in the movie, "Awakenings." Best, Ivan Suzman 50/39/36 :-)) On Sun, 30 Jan 2000 21:57:42 -0500 "J. R. Bruman" <[log in to unmask]> writes: >CURRENT SCIENCE REVIEWS By Joe Bruman February 00 Page 1 of 2 >