Parkinsons Disease Increased Fe3+ binds with dopamine causing increased
lipid peroxidation that is combated by GSH which uses NADPH and becomes
depleted, also depleting complex I. The lipid peroxidation destroys the
neuromelanin cells that have special sites for Fe3+.
Normal Cell
Fe3+ >>>>>>>>>Ferrochelatase
Fe3+>>>(Fe2+ and 2 Sulphur) and
Fe>>>>>>>>>>Fe and Poryphrin
Manganese Toxicity
Fe3+>>>>>Manganese doesn't let iron reach Ferrochelatase.
Elevated levels of Fe3+ combine with dopamine which
cause neuromelanin cells to die.
N-Methyl Tellurium
Fe3+>>>>>>>>Ferrochelatase
Fe3+>>>>(Fe3+ and Tellurium).
Tellurium is a sulphur-like metal that binds metals together.
Unlike sulphur, it does not chelate or break down metals.
N-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine or
MPTP
Fe3+>>>>>>>>Ferrochelatase
Fe3+>>>>(Fe3+) MPTP inhibits
Poryphrin. Ferrochelatase has no where to give the entra iron ion to and
therefore
does not break it down.
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