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---------- > From: Sharon & Jim LeBlanc <[log in to unmask]> > To: [log in to unmask] > Subject: Fe3+ elevation and poryphrin inhibition - Parkinsons > Date: Tuesday, February 01, 2000 3:50 PM > > I've only read two articles on hemochromatosis. > PMID 10638700 Peripheral blood erythrocyte parameters in hemochromatosis: > evidence for incresed erythrocyte hemoglobin content. > PMID 10642169 Recent identified molecular aspects of intestinal iron > absorbtion. > > HFE gene is involved in regulation of intestinal iron absorbtion. > In hemochromatosis probands are caused primarily by increase iron uptake > and hemoglobin synthesis by immature erythroid cells. > > Poryphrin is involved in the synthesis of heme, and the making of > hemoglobin. > MPTP prevents the making of hemoglobin. It inhibits poryphrin. > Manganese does not allow the iron to get to ferrochelatase to break it down > to give it to poryphrin to make hemoglobin. > Tellurium bursts red blood cells, or erythrocytes. It destroys hemoglobin. > Along with messing up ferrochelatase. > > Hemochromatosis speeds up production of hemoglobin to compensate for the > excess Fe3+ iron. > There is an increase of iron, but not a decrease of poryphrin, the body > compensates. > All the players are intact. Fe3+ and Ferrochelatase and Poryphrin. > In Parkinsons, there is both an increase in Fe3+ iron and an inhibition of > poryphrin and heme synthesis. > Now you know why Parkinsons and Leukemia are so close. > Think of tellurium that inhibits heme synthesis and diethylthiocarbamate > that causes anemia - Leukemia. > > Hemochromatosis and Parkinsons both have elevated levels of Fe3+, but are > different because Parkinsons has inhibited poryphrin. > It explains how you could have both diseases. > > Things are making more sense. > A scientist should write a paper on your rare condition of both diseases. > I'll try to find one. > Thank you so much for the insight. > [log in to unmask]