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---------- > From: Kirshner.Annette <[log in to unmask]> > To: [log in to unmask] > Subject: RE: Money for Research > Date: Wednesday, February 02, 2000 9:17 AM > > We used to support a project looking at Tellurium exposure. This was Dr. > Pierre Morell's work at U of N Carolina. He found that Te interferes with > myelin formation. However, exposure to Te is extremely rare. I have been > unable to verify whether Te is in gasoline from our contacts at the Health > Effects Institute. We are supporting an RFA on the role of the environment > in Parkinson's disease and will start funding research from this RFA this > summer so please be assured that we are encouraging the exploration of every > environmental risk factor for PD. > > > -----Original Message----- > > From: Sharon & Jim LeBlanc [SMTP:[log in to unmask]] > > Sent: Tuesday, February 01, 2000 4:20 PM > > To: [log in to unmask] > > Subject: Fw: Money for Research > > > > > > > > ---------- > > > From: Sharon & Jim LeBlanc <[log in to unmask]> > > > To: [log in to unmask] > > > Subject: Money for Research > > > Date: Tuesday, February 01, 2000 3:04 PM > > > > > > Perry Cohen Email Address: [log in to unmask] Parkinsons Disease > > > Association is part of a NIH Planning Task Force that also includes > > Annette > > > Kirshner of NIEHS. It is comprised of 40 scientists and 4 lay officials > > who > > > allocates resources to broad areas of research on Parkinsons Disease. I > > > realize you don't think it is possible for tellurium to cause > > Parkinsons, > > > but you are the only scientist I have been able to find who studies > > > tellurium. Mr. Cohen wrote to me that if I could find a scientist, then > > > perhaps the committee could allocate money. Maybe you have a student who > > > could do the research, or know another scientist studying health and > > > tellurium. > > > > > > Theory: Fe3+ meets Ferrochelatase inside the inner membrane in the > > > normal cell. Ferrochelatase takes the Fe3+ and forms a cluster > > > 2Fe2+2Sulphur and gives away one iron ion to poryphrin. Manganese > > Toxicity > > > and MPTP cause Parkinsons Disease. > > > > > > Manganese does not allow the lactoferrin inside the inner membrane of > > the > > > mitochondria to meet with ferrochelatase so there is a build up of Fe3+. > > > > > > > MPTP or N-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine inhibits poryphrin. > > If > > > there is no poryphrin then there is a build up of Fe3+. > > > N-Methyl-tellurium could take the place of sulphur and prevent the > > > breakdown of Fe3+, causing a build up of Fe3+. The N-Methyl would > > transport > > > it past the blood brain barrier via P-Glycoprotein. P-Glycoprotein binds > > > with NIH 3T3 that activates the RAS oncogene and the MAP Cascade. > > > Methylamine binds tubulin. Lewy Bodies are made of MAP1, MAP2 & Tubulin. > > > > > > > > Theory: Parkinsons Disease is where too much lactoferrin or ferric iron > > or > > > Fe3+ binds with dopamine causing a lipid peroxidation that destroys > > > neuromelanin cells, which have a great affinity for hemosiderin. > > > Lactoferrin and tellurium can be absorbed by bacteria that can also turn > > > tellurite into tellurium and also make N-Methyl. N-Methyl is elevated in > > > Parkinsons, along with (R)Salsolinol which is made when the methylamine > > > forms a formaldehyde that combines with dopamine, turning it into > > > (R)Salsolinol. GSH is used to combat the lipid peroxidation and is low > > in > > > parkinsons. Complex I is inhibited in Parkinsons Disease. Manganese, > > > Tellurium, and MPTP all inhibit Complex I. Manganese via cadmium, > > calcium, > > > ADP, NADP. When I looked up tellurate I found highlighted, diesel fuel, > > > marine diesel fuel, jet fuel, and acrolein. N-Methyl is an additive of > > > fuel. If it inhibits dopamine, then dopamine is inhibited both in MPTP > > and > > > Diethyltelluride. The pyrrole ring found in pigments, like poryphrin, > > > binds with catecholamine which also binds with pyridine. In 1996 > > tellurium > > > was taken off the EPA most dangerous substance list. There are lots of > > > companies selling tellurium on the internet. But then again, you can > > find > > > it in 1911 Mount Clemens Mineral Water. > > > > > > I have lots of research I copied from the internet. Medtox Scientific > > has > > > a new Tellurium test of whole blood, serum and urine. Perhaps you could > > do > > > a study of elevation of tellurium levels in people with Parkinsons > > Disease > > > just to see if anything might be there. Dr. Andrew J Larner wrote about > > > Tellurium and Alzheimers in Pub Med. I'll have to try to find him too. > > > > > > There is a retinoid X mutant mouse that has parkinsonian locomotion. I > > read > > > that retinoid X downregulates metals. I wonder what tellurium would do. > > > Maybe you could explain Parkinsons or ALzheimers that way. > > > > > > Anyway, I'm looking for a scientist to suggest to the committee. Or even > > > someone under your supervision. > > > [log in to unmask]