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Audrey.... As I understand it (and this is the simplified version, 'cause, while I've read the in-depth version several times, over the years, it's never stuck), with PD, the patient's body may still produce (or may NOT still produce..... depending, because Parkinson's must be viewed on a case-by-case basis) some dopamine, however it's apparently not enough to do the job on a 24 hour basis. To complicate matters further, medical research has discovered that seratonin ALSO plays a major roll - on a different level than dopamine. Both these substances play a key roll in keeping the average body functioning. And goodness only knows how many trace-substances are needed to keep the human body running smoothly... Uhhh....Upon rereading, I seemed to have REPLIED to your post, rather than answered your question. <UH DUHm Barbie, get it together> Barb Mallut [log in to unmask] -----Original Message----- From: Audrey <[log in to unmask]> To: [log in to unmask] <[log in to unmask]> Date: Sunday, February 13, 2000 6:22 AM Subject: dopamine Hi list .. A thought struck me after rereading janet marie's comments. Is it a lack of dopamine in PD or is it the inability to manufacture and distribute dopamine in the brain? This is a dumb question probably, and another reason to keep my mouth shut most likely. If it is the lack of dopamine, does it help to use antidepressants (as prozac) to help counteract dopamine loss? I ask because this is the medication I take each day for clinical depression. As I read further about pd, I keep seeing references to restless leg syndrome. This is caused by the lack of dopamine also I believe, and I have had this syndrome as long as I can remember..Why then isn't the family of antidepressants that prozac belongs to more effective in helping PD? If it is, I havent read this anywhere.. Could anyone clarify this for me ? * seattle* audrey friend of PWP