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Increasing your protein is not a good thing if you want your sinemet to be as effective as possible. Protein competes with the levadopa crossing the blood-brain barrier (non-medical, non-professional opinion). Greg 47/35/35 ----- Original Message ----- From: "Stephan Schwartz" <[log in to unmask]> To: <[log in to unmask]> Sent: Wednesday, February 09, 2000 3:18 PM Subject: Mirapex, Requip, Comtran Advice neded -Reply > Hello Bob: > I am 55/dx9 and take SinemetCR 50/200 4x day, Mirapex 1mg 3x day and Comtan 200mg 2x day. > Both Mirapex and Requip have reported the adverse side effect of "sleep attacks." However, if you do not drive a car or operate heavy machinery, the "sleep attacks" can be managed. Increase your protein intake with snacks of nuts (almonds are best), drink orange juice and take a nap once in awhile (beat the meds to it). > Mirapex does alleviate much of my tremors, but the trade off is edema in the ankles. I can control the edema with moderate walking and exercise of the feet, calves and legs. Since an agonist is always recommended, you may want to try Permax a strong, steady agonist -with side effects- but it works at most receptors. > As for your Sinemet dosage, it appears you are under-medicated...Sinemet CR only delivers 75% of the levodopa into the blood stream. You could easily increase to 4x day. > I just started the Comtan three weeks ago and I am working my way up to 4-per day. Generally, no side effects, but not much in the way of symptom relief. I do generally feel better, though. > Good luck. > Stephan 55/9 > > >>> Bob Chapman <[log in to unmask]> 02/09/00 01:01pm >>> > I need some advice from anyone who may have had similar experience with > the following: > I was taking Mirapex (1.5 mg per day) titrated from .375 mg per day over > 8-9 months. I developed swollen ankles and "sleep attacks" the next 2-3 > months. I tried relafin for swollen ankle, didn't work. Dr. then put > ankle in a cast for a month, that didn't work either. I read on the list > where some were having similar problems be cause of Mirapex. I stopped > Mirapex (slowly) and swollen ankles and sleep attacks were gone, 4-5 > months ago. Neuro thinks I am now under medicated because of increased > tremors, slower gait, minor balance problems and increased drooling. He > says I have two options, add requip to meds or add straight Sinemet and > increase Sinemet CR ( I now take 21/2 tabs per day, 50/200 Sinemet CR) > That's my only sinemet med > I am afraid Requip will have the same side effect of swollen ankles and > "Sleep Attacks" as Mirapex did. > What would you do? > Bob Chapman 66/60/55 >