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So then stress in child hood could also be a contributing factor? If that be the case,I don't have a chance in a wind storm. My Mother was an angel but my father was always an angry and hateful man. Shirley -----Original Message----- From: janet marie paterson <[log in to unmask]> To: [log in to unmask] <[log in to unmask]> Date: Wednesday, February 09, 2000 8:52 AM Subject: PMID: 10656535: Cell death of dopamine neurons in aging and Pd >Cell death of dopamine neurons in aging and Parkinson's disease. > >Dopamine neurons in the substantia nigra of human brain are selectively vulnerable and the number decline by aging at 5-10% per decade. > >Enzymatic and non-enzymatic oxidation of dopamine generates reactive oxygen species, which induces apoptotic cell death in dopamine neurons. > >Parkinson's disease (PD) is also caused by selective cell death of dopamine neurons in this brain region. > >The pathogenesis of Parkinson's disease remains to be an enigma, but it was found that an endogenous MPTP-like neurotoxin, 1(R), 2(N)-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline [N-methyl(R)salsolinol, NM(R)Sal], may be one of the pathogenic agents of PD. NM(R)Sal increases in cerebrospinal fluid from untreated parkinsonian patients, and two enzymes, a (R)salsolinol synthase and a neutral N-methyltransferase, synthesize this neurotoxin in the nigro-striatum. > >The activity of a neutral N-methyltransferase is significantly higher in lymphocytes from parkinsonian patients than in control. > >The mechanism of cell death by this toxin was proved to be by the induction of apoptosis, by use of dopaminergic SH-SY5Y cells. > >The apoptosis was suppressed by anti-oxidants, suggesting that the generation of reactive oxygen species may initiate cellular death process. > >These results indicate that in aging and PD oxidative stress induces degeneration of dopamine neurons, and the antioxidant therapy may delay the decline of dopamine neurons in the brain. > > >Mech Ageing Dev 1999 Nov;111(2-3):175-88 >Naoi M, Maruyama W >Institute of Applied Biochemistry, Mitake, Gifu, Japan. ><A HREF="mailto:<[log in to unmask]">[log in to unmask]</A> >PMID: 10656535, UI: 20120328 > ><A HREF="http://www.ncbi.nlm.nih.gov/PubMed/">http://www.ncbi.nlm.nih.gov/PubMe d/</A> > >janet paterson >52 now / 41 dx / 37 onset >a new voice: http://www.geocities.com/janet313/ >613 256 8340 PO Box 171 Almonte Ontario Canada K0A 1A0